Toxicologic Pathology for Non-Pathologists

1. Auflage 2019
ISBN: 978-1-4939-9779-4
Verlag: Springer

Buch, Englisch, 919 Seiten, Format (B × H): 178 mm x 254 mm, Gewicht: 1714 g

This extensive volume began as a short course primarily geared toward toxicologists who want to expand their understanding of toxicologic pathology in order to be better study directors while also proving to be of great interest to other drug development scientists and regulatory reviewers. The overall goal is to help non-pathologists understand, contextualize, and communicate the pathology data and interpretations from the study pathologist in a practical and usable format. Within the book, readers will find an overview of general pathology concepts that include fundamental vocabulary and the basics of pathophysiological processes, along with numerous chapters devoted to pathology in specific organ systems as well as topics such as biomarkers, correlation of clinical pathology endpoints (chemistry and hematology) with microscopic changes, and well-known pathology findings for classes of toxic substances. 
Authoritative, practical, and comprehensive, Toxicologic Pathology for Non-Pathologists aims to help non-pathologists understand, converse in, and apply a basic understanding of pathology in their day-to-day careers.

Zielgruppe

Professional/practitioner

Autoren/Hrsg.

Steinbach, Thomas J.

Cosenza, Mary Ellen

Patrick, Daniel J.

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pathologie, Cytopathologie, Histopathologie

Inhaltsverzeichnis

Introduction to Toxicologic Pathology.- The Pathology Report, Peer Review, and Pathology Working Group.- Routine and Special Techniques in Toxicologic Pathology.- Pathology of the Liver and Gallbladder.- Pathology of the Gastrointestinal Tract and Exocrine Pancreas.- Pathology of the Urinary System.- Pathology of the Nervous System.- Pathology of the Cardiovascular System.- Pathology of the Respiratory System.- Pathology of the Lymphoid System.- Pathology of the Male and Female Reproductive System and Mammary Gland.- Pathology of the Integumentary System.- Pathology of the Endocrine System.- Pathology of Bone, Skeletal Muscle, and Tooth.- Pathology of the Eye.- Pathology of the Ear.- Principles of Toxicologic Clinical Pathology.- Carcinogenicity.- Pathology of Juvenile Animals.- Non-Mammalian Laboratory Species: Fish, Frogs, and Beyond.- Appendix: Fundamental Pathology Terminology Based on the Standard for the Exchange of Nonclinical Data (SEND).

Über Autor(innen)

Thomas J. Steinbach DVM, DACVP, DABT (Experimental Pathology Laboratories, Inc., Research Triangle Park, NC, USA) and Daniel J. Patrick DVM, DACVP, DABT (Charles River Laboratories, Inc., Mattawan, MI, USA) have worked for numerous years to help organize the successful "Pathology for Non-Pathologists" short course, created with the support of the American College of Toxicology (ACT) and Society of Toxicologic Pathology (STP), upon which this book is based. Mary Ellen Cosenza PhD, DABT, RAC, ATS (MEC Regulatory & Toxicology Consulting, LLC, Moorpark, CA, USA) was an inaugural committee member of this short course and remains a highly respected member of the community at large.