Prodrugs

Challenges and Rewards
Softcover Nachdruck of the original 1. Auflage 2007
ISBN: 978-1-4939-5050-8
Verlag: Springer

Buch, Englisch, 1464 Seiten, Previously published in hardcover, Format (B × H): 178 mm x 254 mm, Gewicht: 2746 g

Reihe: Biotechnology: Pharmaceutical Aspects

These volumes represent a comprehensive guide to prodrugs. They guide the reader through the current status of the prodrug concept and its many applications and highlight its many successes in overcoming formulation and delivery of problematic drugs. Replete with examples of approved and marketed prodrugs, these volumes introduce the topic to the novice as well as professional in the design of prodrugs.

Zielgruppe

Research

Autoren/Hrsg.

Stella, Valentino

Borchardt, Ronald

Hageman, Michael

Oliyai, Reza

Maag, Hans

Tilley, Jefferson

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie

Inhaltsverzeichnis

A Case for Prodrugs.- A Case for Prodrugs.- Problems Addressable by Prodrugs.- Prodrug Approaches to Enhancing the Oral Delivery of Poorly Permeable Drugs.- Topical Delivery Using Prodrugs.- Prodrug approaches to ophthalmic drug delivery.- Overcoming Poor Aqueous Solubility of Drugs for Oral Delivery.- Prodrugs and Parenteral Drug Delivery.- Poly (ethylene glycol) Prodrugs: Altered Pharmacokinetics and Pharmacodynamics.- Prodrugs to Reduce Presystemic Metabolism.- Controlled Release — Small Molecules.- Controlled Release - Macromolecular Prodrugs.- Controlled Release - Proenzymes.- Targeting - Theoretical and Computational Models.- Targeting - Cancer — Small Molecules.- Monoclonal Antibody Drug Conjugates for Cancer Therapy.- Antibody-Directed Enzyme Prodrug Therapy.- Prodrugs for Liver-targeted Drug Delivery.- Prodrug Approaches for Drug Delivery to the Brain.- Lymphatic Absorption of Orally Administered Prodrugs.- Colonic Delivery.- Functional Group Approach to Prodrugs.- Prodrugs of Carboxylic Acids.- Prodrugs of Alcohols and Phenols.- Prodrugs of Amines.- Prodrugs of Amides, Imides and Other NH-acidic Compounds.- Prodrugs of Benzamidines.- Prodrugs of Phosphonates, Phosphinates, and Phosphates.- Functional Group Approaches to Prodrugs: Functional Groups in Peptides.- Macromolecular Prodrugs of Small Molecules.- Miscellaneous Functional Groups.- Prodrugs — Preclinical and Clinical Considerations.- Prodrugs: Absorption, Distribution, Metabolism, Excretion (ADME) Issues.- Formulation Challenges of Prodrugs.- Safety Assessment of Prodrugs.- Toxicological Issues with Pivalate Prodrugs.- Case Studies.- Case Study: Adefovir Dipivoxil: An Oral Prodrug of Adefovir.- Case Study: Amifostine: (Ethyol®).- Case Study: Capecitabine: A Prodrug of 5-Fluorouracil.- Case Study:Cefditoren Pivoxil: An Oral Prodrug of Cefditoren.- Case Study: Cefuroxime Axetil: An Oral Prodrug of Cefuroxime.- Case Study: Clindamycin 2-Phosphate, A Prodrug of Clindamycin.- Case Study: Enalapril: A Prodrug of Enalaprilat.- Case Study: Famciclovir: A Prodrug of Penciclovir.- Case Study: Fosamprenavir: A Prodrug of Amprenavir.- Case Study: Fosinopril.- Case Study: Fosphenytoin: A Prodrug of Phenytoin.- Case Study: Irinotecan (CPT-11), A Water-soluble Prodrug of SN-38.- Case Study: Latanoprost: Isopropylester of a Prostaglandin F2? Analog.- Case Study: Moexipril Hydrochloride: A Prodrug of Moexiprilat.- Case Study: Mycophenolate Mofetil.- Case Study: Olmesartan Medoxomil: A Prodrug of Olmesartan.- Case Study: Omeprazole (Prilosec®).- Case Study: Oseltamivir: An Orally Bioavailable Ester Prodrug of Oseltamivir Carboxylate.- Case Study: Parecoxib: A Prodrug of Valdecoxib.- Case Study: Tenofovir Disoproxil Fumarate: An Oral Prodrug of Tenofovir.- Case Study: Travoprost: A Potent PGF2? Analog.- Case Study: Valacyclovir: A Prodrug of Acyclovir.- Case Study: Valganciclovir: A Prodrug of Ganciclovir.- Case Study: Vantin: A Prodrug of Cefpodoxime.- Case Study: Ximelagatran: A Double Prodrug of Melagatran.