Volume 1: Production and Purification
Buch, Englisch, 314 Seiten, Format (B × H): 160 mm x 241 mm, Gewicht: 1420 g
ISBN: 978-0-306-48245-8
Verlag: Springer US
If the antibody industry is to achieve its full potential in the next decade, the individual technical potentials must be exploited, the limitations must be addressed, and lessons learned must be applied both to current purification methods and to the new technologies that continue to emerge. This book presents an overview of the current advances applied in the manufacture of monoclonal antibody including:
-concepts in development of manufacturing strategies,
-importance of antibody fragments,
-application of chromatography method development,
-quality control,
-effect of expression on antibody properties,
-virus removal and safety,
-pharmacokinetics,
-regulatory aspects.
Zielgruppe
Research
Autoren/Hrsg.
Fachgebiete
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie
- Technische Wissenschaften Sonstige Technologien | Angewandte Technik Medizintechnik, Biomedizintechnik
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Pharmazie Apothekenwesen, Apothekenpraxis
- Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Kosmetische Technologie
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Medizintechnik, Biomedizintechnik, Medizinische Werkstoffe
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Immunologie
Weitere Infos & Material
1. Concepts in Development of Manufacturing Strategies for Monoclonal Antibodies.- 2. Antibody Fragments: Production, Purification and Formatting for Therapeutic Applications.- 3. Large Scale Production of Therapeutic Antibodies: Considerations for Optimizing Product Capture and Purification.- 4. Scale-Up of Antibody Purification. From Laboratory Scale to Production.- 5. Purification of Antibody by Chromatographic Methods.- 6. Quality Control of Antibodies for Human Use.- 7. Expression of Human Anti Rh(D) Monoclonal Antibodies into Different Cell lines: Influence on their Functional Properties.- 8. Monoclonal Antibody Production: Minimising Virus Safety Issues.- 9. Contract Manufacturing of Biopharmaceutical Grade Antibodies.- 10. The Pharmacokinetics and Pharmacodynamics of Monoclonal Antibodies.- 11. Regulatory and Legal Requirements for the Manufacture of Antibodies.
