Antibodies

Vol 1 + 2
2004. Auflage 2004
ISBN: 978-0-306-48334-9
Verlag: Springer

Buch, Englisch, 550 Seiten, Format (B × H): 151 mm x 235 mm, Gewicht: 1161 g

If the antibody industry is to achieve its full potential in the next decade, the individual technical potentials must be exploited, the limitations must be addressed, and lessons learned must be applied both to current purification methods and to the new technologies that continue to emerge. This book presents an overview of the current advances applied in the manufacture of monoclonal antibody including:

-concepts in development of manufacturing strategies,
-importance of antibody fragments,
-application of chromatography method development,
-quality control,
-effect of expression on antibody properties,
-virus removal and safety,
-pharmacokinetics,
-regulatory aspects.

Zielgruppe

Research

Autoren/Hrsg.

Subramanian, G.

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Pharmazie Apothekenwesen, Apothekenpraxis
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Immunologie
• Technische Wissenschaften Sonstige Technologien | Angewandte Technik Medizintechnik, Biomedizintechnik
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Medizintechnik, Biomedizintechnik, Medizinische Werkstoffe
• Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Kosmetische Technologie

Inhaltsverzeichnis

Volume 1:-1. Concepts in Development of Manufacturing Strategies for Monoclonal Antibodies; 2. Antibody Fragments: Production, Purification and Formatting for Therapeutic Applications; 3. Large Scale Production of Therapeutic Antibodies: Considerations for Optimizing Product Capture and Purification; 4. Scale-Up of Antibody Purification. From Laboratory Scale to Production; 5. Purification of Antibody by Chromatographic Methods; 6. Quality Control of Antibodies for Human Use; 7. Expression of Human Anti Rh(D) Monoclonal Antibodies into Different Cell lines: Influence on their Functional Properties; 8. Monoclonal Antibody Production: Minimising Virus Safety Issues; 9. Contract Manufacturing of Biopharmaceutical Grade Antibodies; 10. The Pharmacokinetics and Pharmacodynamics of Monoclonal Antibodies; 11. Regulatory and Legal Requirements for the Manufacture of Antibodies; Index.
Volume 2:-1. Transgenic technology for monoclonal antibody production; 2. Generation, engineering and production of human antibodies using HuCAL; 3. Achieving appropriate glycosylation during the scaleup of antibody production; 4. Approaches to devise antibody purification processes by chromatography; 5. Novel HIV neutralizing antibodies selected from phage display libraries; 6. Monoclonal and bispecific antibodies in combination with radiotherapy for cancer treatment; 7. Antibodies, a potent tool to target genes into designated cells and tissues; 8. Intrabodies: development and application in functional genomics and therapy; 9. Expression of recombinant antibodies by tumour cells: on road to anti-tumour therapy; 10. Antitumor antibodies: from research to clinic; 11. Macrophages for immunotherapy; 12. Future prospects in antibody engineering and therapy; Index.