The Human Hypothalamus

Neuropsychiatric Disorders Volume 182
Erscheinungsjahr 2021
ISBN: 978-0-12-819973-2
Verlag: Elsevier Science

Buch, Englisch, 516 Seiten, Format (B × H): 195 mm x 260 mm, Gewicht: 1360 g

The Human Hypothalamus: Neuropsychiatric Disorders, Volume 181 in the Handbook of Clinical Neurology series, provides comprehensive summaries of recent research on the brain and nervous system as they relate to clinical neurology. This volume identifies the neurobiology and neurophysiology of disorders relating to the hypothalamus and provides treatment information for these disorders. Disorders covered include neuropsychiatric, neurodegenerative, periodic, and autoimmune disorders. Coverage includes Alzheimer's, Parkinson's, epilepsy, sleep, pain, depression, anxiety, OCD, PTSD, schizophrenia, autism, aggressions, addiction, and more.

Zielgruppe

Clinical neurologists, researchers in neurology

Autoren/Hrsg.

Swaab, Dick F

Buijs, Ruud M.

Kreier, Felix

Lucassen, Paul J.

Salehi, Ahmad

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Endokrinologie
• Interdisziplinäres Wissenschaften Wissenschaften Interdisziplinär Neurowissenschaften, Kognitionswissenschaft
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pathologie, Cytopathologie, Histopathologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Physiologie

Inhaltsverzeichnis

1. Introduction: The human hypothalamus and neuropsychiatric disorders

SECTION 21 Trauma and iatrogenic disorders
2. Chronic traumatic encephalopathy and the nucleus basalis of Meynert

SECTION 22 Neurobehavioral disorders
3. Hypothalamic stress systems in mood disorders

4. Light therapy for mood disorders

5. Neurobiology of peripartum mental illness

6. The hypothalamo-pituitary-adrenal axis and the autonomic nervous system in burnout
7. Posterior hypothalamus as a target in the treatment of aggression: From lesioning to deep brain stimulation
8. The implications of hypothalamic abnormalities for schizophrenia

9. The promiscuity of the oxytocin-vasopressin systems and their involvement in autism
spectrum disorder

SECTION 23 Epilepsy
10. Gelastic seizures and the hypothalamic hamartoma syndrome: Epileptogenesis beyond the lesion?

11. The interactions between reproductive hormones and epilepsy

SECTION 24 Neurodegenerative disorders
12. Alternative splicing in aging and Alzheimer's disease: Highlighting the role of tau and estrogen receptor a isoforms in the hypothalamus

13. Cholinergic neurodegeneration in Alzheimer disease mouse models

14. Autonomic disorders in Parkinson disease: Disrupted hypothalamic connectivity as revealed from resting-state functional magnetic resonance imaging
15. Hypothalamic a-synuclein and its relation to autonomic symptoms and neuroendocrine abnormalities in Parkinson disease

16. Lewy bodies in the olfactory system and the hypothalamus

17. Hypothalamic pathology in Huntington disease

18. Endocrine dysfunction in adrenoleukodystrophy

19. Hypothalamic symptoms of frontotemporal dementia disorders
SECTION 25 Olfactory system
20. The vomeronasal organ: History, development, morphology, and functional neuroanatomy

21. Pheromone effects on the human hypothalamus in relation to sexual orientation and gender
22. Kallmann syndrome and idiopathic hypogonadotropic hypogonadism: The role of semaphorin signaling on GnRH neurons

23. Olfaction as an early marker of Parkinson's disease and Alzheimer's disease

SECTION 26 Autonomic and sleep disorders
24. The hypothalamus and its role in hypertension

25. The heart is lost without the hypothalamus
26. Sleep disorders and the hypothalamus

SECTION 27 Addiction and pain
27. Molecular genetics of neurotransmitters and neuropeptides involved in Internet use disorders including first insights on a potential role of hypothalamus' oxytocin hormone

28. The neurobiology of cluster headache

SECTION 28 Critical care and brain-death
29. Endocrine interventions in the intensive care unit

30. Hypothalamic function in patients diagnosed as brain dead its practical consequences

Über Autor(innen)

Lucassen, Paul J.
Paul J. Lucassen did his PhD in 1995 on Alzheimer's Disease at the Netherlands Institute for Brain Research in Amsterdam.
After a.o. a postdoc in Leiden, he became Full Professor of Brain Plasticity in 2011 at the Swammerdam Institute for Life Sciences (SILS) of the University of Amsterdam, The Netherlands.
His group studies molecular, nutritional, pharmacological and environmental regulation of brain plasticity. They combine molecular tools, in vitro/vivo model systems, human brain tissue, cohort studies and brain imaging. A major focus is on adult neurogenesis and cognition in relation to; (early life) stress, exercise, enrichment, depression, brain insults and dementia.

Salehi, Ahmad
Ahmad Salehi is affiliated with Stanford Medical School, Department of Psychiatry & Behavioral Sciences, in Palo Alto, CA, United States.

Kreier, Felix
Felix Kreier is a pediatrician and affiliated with OLVG Hospitals in Amsterdam, The Netherlands.

Buijs, Ruud M.
Dr. Ruud M. Buijs is head of the Physiology department of the I.I.Biomedicas at the UNAM university and leader of the group Hypothalamic Integration Mechanisms. In that group, the scientists study how the brain and body interact with each other, and hereby the attention is focussed on autonomic and hormonal regulation of body functions under the influence of the biological clock of the brain.