Taniguchi / Honke / Fukuda Handbook of Glycosyltransferases and Related Genes

2002
ISBN: 978-4-431-67877-9
Verlag: Springer Tokyo
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 670 Seiten, eBook

The so-called postgenomic research era has now been launched, and the field of gly cobiology and glycotechnology has become one of the most important areas in life science because glycosylation is the most common post-translational modification reaction of proteins in vivo. On the basis of Swiss-Prot data, over 50% proteins are known to undergo glycosylation, but in fact the actual functions of most of the sugar chains in the glycoconjugates remain unknown. The complex carbohydrate chains of glycoproteins, glycolipids, and proteoglycans represent the secondary gene products formed through the reactions of glycosyl transferases. The regulation of the biosynthesis of sugar chains is under the control of the expression of glycosyltransferases, their substrate specificity, and their local ization in specific tissue sites. There is a growing body of evidence to suggest that these enzymes play pivotal roles in a variety of important cellular differentiation and developmental events, as well as in disease processes. Over 300 glycosyltransferases appear to exist in mammalian tissues. If the genes that have been purified and cloned from various species such as humans, cattle, pigs, rats and mice are counted as one, approximately 110 glycogenes that encode glycosyltransferases and related genes have been cloned at present, and this number continues to grow each day. However, most of the functions of the glycosyltransferase genes and related genes are unknown. This fact has stimulated numerous new and interesting approaches in molecular biologi cal investigations.

Zielgruppe

Research

Autoren/Hrsg.

Taniguchi, Naoyuki

Honke, Koichi

Fukuda, Minoru

Inhaltsverzeichnis

Part 1Glucosyltransferase
1 GlcCer Synthase (UDP-Glucose:Ceramide Glucosyltransferase, UGCG)
Part 2Galactosyltransferases
2 b4-Galactosyltransferase-I
3 b4-Galactosyltransferase-II, -III, -IV, -V, -VI, and -VII
4 b3-Galactosyltransferase-I , -II, and -III
5 b3-Galactosyltransferase-IV (GM1 Synthase)
6 b3-Galactosyltransferase-V
7 a3-Galactosyltransferase
8 GalCer Synthase (Ceramide Galactosyltransferase, CGT)
Part 3N-Acetylglucosaminyltransferases
9 N-Acetylglucosaminyltransferase-I
10 N-Acetylglucosaminyltransferase-II
11 N-Acetylglucosaminyltransferase-III
12 N-Acetylglucosaminyltransferase-IV
13 N-Acetylglucosaminyltransferase-V
14 N-Acetylglucosaminyltransferase-VI
15 b3-N-Acetylglucosaminyltransferase (Fringe)
16 b3-N-Acetylglucosaminyltransferase (iGnT)
17 b6-N-Acetylglucosaminyltransferase (IGnT)
18 Core 2 b6-N-Acetylglucosaminyltransferase-1 and -3
19 Core 2 b6-N-Acetylglucosaminyltransferase-2
20 a4-N-Acetylglucosaminyltransferase
21 O-GlcNAc Transferase
Part 4N-Acetylgalactosaminyltransferases
22 Polypeptide N-Acetylgalactosaminyltransferases
23 b4-N-Acetylgalactosaminyltransferase
24 Histoblood Groups A and B Transferases, Their Gene Structures, and Common O Group Gene Structures
25 Histoblood Group A Variants, O Variants, and Their Alleles
26 Forssman Glycolipid Synthase
Part 5Fucosyltransferases
27 a2-Fucosyltransferases (FUT1, FUT2, and Sec1)
28 a3/4-Fucosyltransferase (FUT3, Lewis Enzyme)
29 a3-Fucosyltransferase-IV (FUT4)
30 a3-Fucosyltransferase-V (FUT5)
31 a3-Fucosyltransferase-VI (FUT6)
32 a3-Fucosyltransferase-VII (FUT7)
33 a3-Fucosyltransferase-IX (FUT9)
34 a6-Fucosyltransferase (FUT8)
Part 6Sialyltransferases
35 ST3Gal-I
36 ST3Gal-II (SAT-IV)
37 ST3Gal-III
38 ST3Gal-IV
39 ST3Gal-V (GM3 Synthase, SAT-I)
40 ST6Gal-I
41 ST6GalNAc-I
42 ST6GalNAc-II
43 ST6GalNAc-III(STY)
44 ST6GalNAc-IV
45 ST8Sia-I (GD3 Synthase, SAT-II)
46 ST8Sia-II (STX)
47 ST8Sia-III
48 ST8Sia-IV (PST-1)
49 ST8Sia-V (SAT-V/SAT-III)
50 CMP-NeuAc Hydroxylase
Part 7Glucuronyltransferases
51 HNK-1 Glucuronyltransferase
52 GAG Glucuronyltransferase-I
53 UDP-Glucose Dehydrogenase
Part 8GAG Synthesis
54 a4-N-Acetylhexosaminyltransferase (EXTL2)
55 Hyaluronan Synthase-1, -2, and -3
56 Heparan Sulfate GlcA/GlcNAc Transferase
57 D-Glucuronyl C5-Epimerase in Heparin/Heparan Sulfate Biosynthesis
Part 9Sulfotransferases
58 Chondroitin 6-Sulfotransferase
59 Keratan Sulfate Gal-6-Sulfotransferase
60 Corneal N-Acetylglucosamine 6-O-Sulfotransferase
61 N-Acetylglucosamine-6-O-Sulfotransferase
62 Intestinal N-Acetylglucosamine 6-O-Sulfotransferase
63 High Endothelial Cell N-Acetylglucosamine
6-O-Sulfotransferase
64 Chondroitin 4-Sulfotransferase
65 HNK-1 Sulfotransferase
66 Galactosaminoglycan Uronyl 2-Sulfotransferase
67 Heparan Sulfate 2-Sulfotransferase
68 Heparan Sulfate 6-Sulfotransferase
69 Heparan Sulfate D-Glucosaminyl 3-O-Sulfotransferase-1, -2, and -3
70 Heparan Sulfate N-Sulfotransferase-1
71 Heparan Sulfate N-Sulfotransferase-2
72 Heparan Sulfate N-Sulfotransferase-3 and -4
73 bGal 3-O-Sulfotransferase-1, -2, -3, and -4
Part 10 Nucleotide Sugar Transporters
74 UDP-Gal Transporter-1 and -2
75 UDP-GlcNAc Transporter
76 CMP-Sialic Acid Transporter
Part 11 Dolichol Pathway/GPI-Anchor
77 GPI-GlcNAc Transferase: Complex of PIG-A, PIG-C, PIG-H, hGPI1, and PIG-P
78 Dolichol Phospho-Mannose Synthase (DPM1 and DPM2)
79 PIG-B, GPI-Man Transferase III, Man-(Ethanolaminephosphate)Man-GlcN-(Acyl)PI Mannosyltransferase
80 Dolichol Phosphate GlcNAc-1-P Transferase
81 ALG3 Mannosyltransferase
82 ALG6 Glucosyltransferase
Part 12 N-Glycan Processing Enzymes
83 Oligosaccharyltransferase Complex, Ribopho