Radical and Ion-Pairing Strategies in Asymmetric Organocatalysis

Erscheinungsjahr 2017
ISBN: 978-1-78548-127-7
Verlag: Elsevier Science

Buch, Englisch, 184 Seiten, Format (B × H): 155 mm x 231 mm, Gewicht: 408 g

Considering the challenge of sustainability facing our society in the coming decades, catalysis is without any doubt a research area of major importance. In this regard, asymmetric organocatalysis, now considered a pillar of green chemistry, deserves particular attention.

The first chapter of this volume examines the topic of asymmetric organocatalysis in light of radical chemistry. Recent important progress in this field has been attained by promoting the formation and harnessing the high reactivity of open-shell intermediates. Merging organocatalysis with radical chemistry has been the key to solving some longstanding bottlenecks, and has also significantly contributed to reinforcing the key role of organocatalysis in asymmetric catalysis. This chapter presents the most significant developments in this area, with a particular focus on asymmetric SOMO- and photoredox-organocatalyzed transformations.

Chapter 2 focuses on quaternary ammonium salts (R4N+X-), especially chiral derivatives, and their behavior as unique catalysts in organocatalysis. Forming chiral ion-pairs capable of promoting asymmetric reactions, they also operate as unique "transporters� involved in phase transfer catalytic processes between liquid-liquid or liquid-solid systems. Furthermore, they offer unique opportunities when forming cooperative ion-paired entities R4N+X-, allowing a synergistic implication of the counter-ion X- either as Br�nsted bases or Lewis bases. Specific design of such chiral catalysts in modern chemistry and better insight into their mode of activation facilitates efficient and unprecedented chemical transformations. This chapter provides an overview of the use of chiral quaternary ammonium salts in organocatalysis, emphasizing both general mechanistic aspects and the scope of this approach.

Zielgruppe

<p>Master and PhD students, chemistry teachers for pedagogical purposes</p>

Autoren/Hrsg.

Vitale, Maxime R

Oudeyer, Sylvain

Levacher, Vincent

Briere, Jean-Francois

Fachgebiete

• Naturwissenschaften Chemie Physikalische Chemie Biokatalyse

Inhaltsverzeichnis

1. SOMO and Photoredox Asymmetric Organocatalysis 1.1. Introduction 1.2. Asymmetric SOMO organocatalysis 1.3. Asymmetric photoredox organocatalysis 1.4. Conclusions 1.5. Bibliography

2. Chiral Quaternary Ammonium Salts in Organocatalysis 2.1. Introduction 2.2. Phase transfer catalysis 2.3. Cooperative ion pairs organocatalysts 2.4. Conclusions 2.5. Bibliography

Über Autor(innen)

Vitale, Maxime R
Maxime R. Vitale is a researcher at the French National Scientific Research Center (CNRS).

Briere, Jean-Francois
Jean-François Brière is CNRS researcher in the COBRA laboratory at the University of Rouen Normandy (Organocatalysis axis - heterocycles team).

Levacher, Vincent
Vincent Levacher is head of the heterocycles team in the COBRA laboratory at the University of Rouen Normandy.

Oudeyer, Sylvain
Sylvain Oudeyer is a lecturer at the University of Rouen Normandy (Organocatalysis axis - heterocycles team).