Wang / Urban Predictive ADMET

Integrated Approaches in Drug Discovery and Development
1. Auflage 2014
ISBN: 978-1-118-78340-5
Verlag: John Wiley & Sons
Format: EPUB
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 616 Seiten, E-Book

This book helps readers integrate in silico, invitro, and in vivo ADMET (absorption,distribution, metabolism, elimination and toxicity) and PK(pharmacokinetics) data with routine testing applications so thatpharmaceutical scientists can diagnose ADMET problems and presentappropriate recommendations to move drug discovery programsforward.
The book introduces the current clinical practice for drugdiscovery and development along with the impact on early riskassessment; consolidates the tools and models to intelligentlyintegrate existing in silico, invitro and in vivo ADMET data; anddemonstrates successful cases and lessons learned from real drugdiscovery and development. In short, it is a book aimed to providea practical road map for drug discovery and development scientiststo generate efficacious and safe drugs for unmet medical needs.

Autoren/Hrsg.

Wang, Jianling

Urban, Laszlo

Über Autor(innen)

Jianling Wang is the Cambridge Head of DiscoveryADME at Novartis Institutes for BioMedical Research. He haspublished over 40 journal papers, reviews, and book chapters andlectured at over 30 scientific conferences and courses.Laszlo Urban is the Executive Director for PreclinicalSafety Profiling at Novartis Institutes for BioMedical Research. Hehas over 10 years of experience in academia and 20 years in thepharmaceutical industry. Among Dr. Urban's publications areover 120 peer-reviewed scientific papers, 3 booksincluding Hit and Lead Profiling: Identification andOptimization of Drug-like Molecules (Wiley, 2009).