Wiendl / Korsukewitz / Kieseier Multiple Sklerose

Klinik, Diagnostik und Therapie
2. erweiterte und überarbeitete Auflage 2021
ISBN: 978-3-17-035372-5
Verlag: Kohlhammer
Format: EPUB
Kopierschutz: 6 - ePub Watermark

E-Book, Deutsch, 250 Seiten

There has been a fundamental change in our understanding of multiple sclerosis in recent years, affecting the pathogenesis of the condition as well its treatment, diagnosis and care. This volume presents these advances in a clear and application-oriented way and reflects all areas of the current state of knowledge on multiple sclerosis. As a reference work as well as a guide, it provides specific recommendations on diagnosis and therapy, with a focus on practical issues and aspects of patient care. In addition to background information about suspected pathological mechanisms, approaches to treatment monitoring are presented using diagrams. The book is rounded off by an overview of proven and new drugs, their mechanisms of action and aspects that need to be taken into account when there is a possible change of therapy. The book represents a unique companion for everyday clinical practice in the German-speaking countries.

Prof. Heinz Wiendl is Director of the Department of Neurology and Institute of Translational Neurology at the University of Münster. Dr. Catharina Korsukewitz is a senior physician in the Department of Neurology and Institute of Translational Neurology at the University of Münster. Prof. Bernd C. Kieseier is a senior physician in the Department of Neurology at Heinrich Heine University of Düsseldorf.

Autoren/Hrsg.

Wiendl, Heinz

Korsukewitz, Catharina

Kieseier, Bernd C.

Leseproben

Abkürzungsverzeichnis

ABE	Hirnstammenzephalitis

ACTH	Adrenocorticotropes Hormon

ADEM	Akute disseminierte Enzephalomyelitis

aHSCT

Autologe hämatopoetische Stammzelltransplantation

ALS	Amyotrophe Lateralsklerose

ALT	Alanin-Aminotransferase

AM	Akute Myelitis

AML	Akute myeloische Leukämie

AMPA	a-Amino-3-Hydroxy-5-Methyl-4-Isoxazol-Proprionsäure

APC/APZ

Antigen präsentierende Zelle

APLs	Veränderte Peptidliganden (engl.: altered peptide ligands)

APP	ß-Amyloid-Vorläuferprotein

APRIL

Ein Proliferation auslösender Ligand (a proliferation-inducing ligand)

APS	Area postrema Syndrom

ATG	Antithymozytenglobulin

AZA	Azathioprin

BAFF	B-Zell aktivierender Faktor der TNF-Familie

BDNF	Brain-derived neurotrophic factor

BS	Balos konzentrische Sklerose

CB	Cannabinoide

CBZ	Carbamazepin

CCL	Chemokinligand

CDR	Complementary determining region

CIS	Klinisch isoliertes Syndrom

CNTF	Ciliary neurotrophic factor

CTX	Cyclophosphamid

DC	Dendritische Zelle

DMF	Dimethylfumarat

DMPA	Depot-Methylprednisolonacetat

DNA/DNS

Desoxyribonukleinsäure (desoxyribonucleic acid)

DS	Zwischenhirnsyndrom

DSG	Deoxyspergualin

DSS	Disability Status Scale

EAE	Experimentelle autoimmune Enzephalomyelitis

EBV	Epstein-Barr-Virus

EDSS	Expanded Disability Status Scale

Epo	Erythropoetin

FS	Funktionelles System

GA	Glatirameracetat

GABA	Gamma-Aminobuttersäure

GCS	Glukokortikosteroide

G-CSF

Granulozytenkolonie-stimulierender Faktor

GI	gastrointestinal

HAM	HTLV-I-assoziierte Myelopathie

HSCT	Hämatopoetische Stammzelltransplantation

i. m.

intramuskulär (lat.: in musculo)

i. v.

intravenös (lat.: in vena)

ICAM	Intracellular adhesion molecule

IFN	Interferon

Ig	Immunglobulin

IGF	Insulin-like growth factor-1

IL	Interleukin

ITP	Idiopathische thrombozytopenische Purpura

IvIg	Intravenöse Immunglobuline

JCV	Humanes Polyomavirus (auch John-Cunningham-Virus)

KM	Kontrastmittel

KOF	Körperoberfläche

LETM	Longitudinale extensive transverse Myelitis

LFA	Mit der Lymphozytenfunktion assoziiertes Antigen (lymphocyte-function associated antigen)

LHON	Lebersche hereditäre Optikusneuropathie

LIF	Leukemia-inhibitory factor

LP	Liquorpunktion

LVEF	Linksventrikuläre Auswurffraktion

MAG	Myelin-assoziierte Glykoproteine

mAk	Monoklonaler Antikörper

MBP	Basisches Myelinprotein (myelin basic protein)

MEP	Transkraniell magnetisch evozierte Potenziale

MHC	Haupthistokompatibilitätskomplex (major hostocompatibility complex)

MIX	Mitoxantron

MMP	Matrix-Metalloproteinasen

MOG	Myelin Oligodendrozyten-Glykoprotein

MP	Methylprednisolon

MRT	Magnetresonanztomografie

MS	Multiple Sklerose

MSC	Mesenchymale Stammzelltransplantation

MSFC	Multiple Sclerosis Functional Composite Score

MSRV	Multiple Sklerose-assoziiertes Retrovirus

MTX	Methotrexat

NAB	Neutralisierender Antikörper

NEDA	Keine Anzeichen von Krankheitsaktivität (engl.: no evidence of disease activity)

NK-Zelle

Natürliche Killerzelle

NMDA	N-Methyl-D-Aspartat

NMO	Neuromyelitis optica (auch Devic Syndrom, Morbus Devic)

NMOSD

Erkrankungen des Neuromyelitis optica-Spektrums (engl.: neuromyelitis optica spectrum disease)

Nrf2	NF-related factor 2

NSAR	nicht-steroidale Antirheumatika

NTZ	Natalizumab

NW	Nebenwirkung

ODC	Oligodendrozyten-Zelle

OG	Oligodendrozyten-Glia-Zelle

OKB	Oligoklonale Banden

OPC	Oligodendrozyten-Vorläuferzelle (oligodendocyte precursor cells)

OPN	Osteopontin

OSMS	Optikospinale Form der MS

p. o.

oral verabreicht (lat.: per os)

PASAT

Paced auditory serial additions test

PCR	Polymerase-Kettenreaktion

PD-1	Programmed death-1

PLP	Proteolipid-Protein

PML	Progressive multifokale Leukenzephalopathie

PMS	Progrediente MS

PPAR?

Peroxisom-proliferationsaktivierter Rezeptor-gamma

PPMS	Primär progrediente MS

PSGL	P-Selektin-Glykoprotein-Ligand

RION	Rekurrierende, isolierte...

Über Autor(innen)

Prof. Heinz Wiendl is Director of the Department of Neurology and Institute of Translational Neurology at the University of Münster. Dr. Catharina Korsukewitz is a senior physician in the Department of Neurology and Institute of Translational Neurology at the University of Münster. Prof. Bernd C. Kieseier is a senior physician in the Department of Neurology at Heinrich Heine University of Düsseldorf.