Modern NMR Approaches to Natural Products Structure Elucidation

Complete Set
Erscheinungsjahr 2016
ISBN: 978-1-84973-459-2
Verlag: RSC Publishing

Buch, Englisch, 861 Seiten, Format (B × H): 163 mm x 236 mm, Gewicht: 1542 g

This two volume set focuses on the structure elucidation of natural products. Volume 1 discusses contemporary NMR approaches including optimized and future hardware and experimental approaches to obtain both the highest quality and most appropriate spectral data for analysis. Volume 2 considers data processing and algorithmic based analyses tailored to natural product structure elucidation and reviews the application of NMR to the analysis of a series of different natural product families including marine natural products, terpenes, steroids, and carbohydrates. These books, bringing together acknowledged experts, uniquely focus on the combination of experimental approaches and modern hardware and software applied to the structure elucidation of natural products. The volumes will be an essential resource for NMR spectroscopists, natural product chemists and industrial researchers working on natural product analysis or the characterization of impurities and degradation products of pharmaceuticals that can be scarce as natural product samples.

Autoren/Hrsg.

Williams, Antony

Martin, Gary

Rovnyak, David

Fachgebiete

• Naturwissenschaften Chemie Organische Chemie
• Naturwissenschaften Chemie Analytische Chemie Magnetresonanz

Inhaltsverzeichnis

Modern NMR Approaches to the Structure Elucidation of Natural Products - Volume 1: Instrumentation and Software

An Introduction to Modern NMR Spectroscopy for the Elucidation of Natural Products

NMR Magnets, a Historical Overview

Small volume NMR - Microprobes and Nanoprobes

Cryogenically Cooled NMR Probes: A Revolution for NMR Spectroscopy

Application of LC-NMR to the Study of Natural Products

Application of Non-uniform Sampling for Sensitivity Enhancement of Small Molecule Heteronuclear Correlation NMR Ppectra

NMR Spectroscopy using Several Parallel Receivers

Dereplication Using H1 NMR

Application of Computer Assisted Structure Elucidation

Multidimensional Spin Correlations by Covariance NMR

Future Approaches For Data Processing

Nutriceuticals

Molecular Structure Identification by Atomic Force Microscopy

Modern NMR Approaches to the Structure Elucidation of Natural Products - Volume 2: Data Acquisition and Applications to Compound Classes

Application of the Nuclear Overhauser Effect to the Structural Elucidation of Natural Products

Assigning Molecular Configuration by Nuclear Magnetic Resonance

Nuclear Magnetic Resonance Experiments Applicable to the Elucidation and Characterization of Nitrogenous Natural Products: 1H-15N Heteronuclear Shift Correlation Methods

Application of Residule Dipolar Couplings to the Structural Analysis of Natural Products

Applications of High-resolving Power, High-accuracy Mass Spectrometry for the Structural Elucidation of Natural Products

Current Pulse Sequence Developments in Small-molecule Nuclear Magnetic Resonance Spectroscopy

Terpenes: Mono-, Sesqui-, and Higher Terpenes

Nuclear Magnetic Resonance of Steroids

Nuclear Magnetic Resonance Experiments Applicable to the Elucidation and Characterization of Alkaloid Structures Part 1: Direct 1H-13C Heteronuclear Shift Correlation and Establishing Contiguous Protonated Carbon Spin Systems

Nuclear Magnetic Resonance Experiments Applicable to the Elucidation and Characterization of Alkaloid Structures Part 2: Advanced Techniques for the Identification of Adjacent Carbons Using H2BC,1,1-ADEQUATE, and Variants

Nuclear Magnetic Resonance Case Studies in Marine Natural Products

Nuclear Magnetic Resonance Case Studies in Microbial Natural Products

Nuclear Magnetic Resonance in Saponin Structure Elucidation

Increasing the Adoption of Advanced Techniques for the Structure Elucidation of Natural Products

Über Autor(innen)

Antony J. Williams graduated with a BSc and PhD in chemistry from the University of Liverpool and University of London respectively. He subsequently became a Post-doctoral Fellow at the National Research Council in Ottawa and then an NMR Facility Director at the University of Ottawa. He has also worked as an NMR Technology Leader at Eastman-Kodak Company in Rochester and held a number of positions, including Chief Science Officer, at ACD/Labs. In 2007, he established ChemZoo, Inc and became host of ChemSpider, one of the primary internet portals for chemistry. ChemSpider was acquired by the Royal Society of Chemistry (RSC) in 2009 and Dr Williams is currently Vice-President of Strategic Development at the RSC. He presently holds an adjunct position at UNC-Chapel Hill and has been a member of the ACS since 1996. Gary E. Martin graduated with a BS in Pharmacy in 1972 from the University of Pittsburgh and a PhD in Pharmaceutical Sciences from the University of Kentucky in 1975, specializing in NMR spectroscopy. He was a Professor at the University of Houston from 1975 to 1989, assuming the position of Section Head responsible for US NMR spectroscopy at Burroughs Wellcome, Co. in Research Triangle Park, NC, eventually being promoted to the level of Principal Scientist. In 1996 he assumed a position at what was initially the Upjohn Company in Kalamazoo, MI and held several positions there through 2006 by which time he was a Senior Fellow at what was then Pfizer, Inc. In 2006 he assumed a position as a Distinguished Fellow at Schering-Plough responsible for the creation of the Rapid Structure Characterization Laboratory. He is presently a Distinguished Fellow at Merck Research Laboratories. David Rovnyak earned his BS from the University of Richmond, and his PhD studying high resolution NMR of quadrupolar nuclei at MIT. He transitioned to solution phase biomolecular NMR in postdoctoral work at the Harvard Medical School before joining the Chemistry Department at Bucknell University, where he has been recognized with Bucknell's Excellence in Teaching Award. He currently serves as Assistant Editor of Concepts in Magnetic Resonance. His lab pursues interdisciplinary topics in biophysical research including bile acid aggregation, methods in protein NMR, nonuniform sampling and small molecule profiling.