Wong Carbohydrate-based Drug Discovery

1. Auflage 2006
ISBN: 978-3-527-60578-1
Verlag: Wiley-VCH
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 948 Seiten, E-Book

Die Suche nach Medikamenten mit neuen oder verbesserten Eigenschaften hat das Interesse am pharmazeutischen Potenzial von Kohlenhydraten enorm verstärkt. Dies gilt insbesondere für die Entwicklung von Antibiotika, Impfstoffen und Anti-Krebs-Mitteln. Carbohydrate-based Drug Discovery stellt mit mehr als 50 Beiträgen der weltweit führenden Experten die neuesten Entwicklungen in der Kohlenhydrat- und Biochemie vor. Dabei liegt der Schwerpunkt der Darstellung auf der pharmazeutischen Anwendung.
 
In jüngster Zeit sind wirksame, auf Kohlenhydraten basierende Medikamente gegen HIV, Grippe, Epilepsie, Diabetes und Krebs auf den Markt gekommen bzw. werden in Studien klinisch erprobt. Doch das gesamte Potenzial dieser Substanzklasse kann man bislang wohl nur erahnen. Die pharmazeutische Industrie investiert bereits große Summen in die Forschung und Entwicklung.
So kommt dieses Handbuch genau zur richtigen Zeit. Umfassend und kompetent behandelt es den gesamten Bereich der Kohlenhydratchemie. Es führt ein in die chemische Synthese, in Biosynthese und Metabolismus und informiert über die Analyse und die zellulären Funktionen von Kohlenhydraten. Einen weiteren Schwerpunkt bildet die Entwicklung von Medikamenten auf Kohlenhydrat-Basis, wie z.B. synthetischer Impfstoffe oder Thrombosemittel auf Basis synthetischer Oligosaccharide. Erschlossen wird das mit einem umfangreichen bibliographischen Anhang versehene Werk durch einen thematischen Index.
Sein Herausgeber, Chi-Huey Wong, hat bereits mehrere internationale Preise für sein wissenschaftliches Werk erhalten, darunter den "Presidential Award" und den "Presidential Young Investigator Award".

Autoren/Hrsg.

Wong, Chi-Huey

Inhaltsverzeichnis

Complex Carbohydrate Synthesis
The Chemistry of Sialic Acid
Solid-Phase Oligosaccharide Synthesis
Solution and Polymer-supported Synthesis of Carbohydrates
Enzymatic Synthesis of Oligosaccharides
Glycopeptides and Glycoproteins: Synthetic Chemistry and Biology
Chemistry and Biochemistry of Asparagine-linked Protein Glycosylation
Conformational Analysis of C-Glycosides and Related Compounds
Synthetic Lipid A Analogs for Sepsis Treatment
Polysialic Acid Vaccines
Synthetic Carbohydrate-based Vaccines
Antithrombotics Based on Synthetic Oligosaccharides
Sequencing of Oligosaccharides and Glycoproteins
Analytical Techniques for the Characterization and Sequencing of Glycosaminoglycans
Synthetic Multivalent Carbohydrate Ligands as Effectors or Inhibitors of Biological Processes
Glycosyltransferase Inhibitors
RNA-Aminoglycoside Interactions
Glycosylated Natural Products
Small Molecule Inhibitors of the Sulfotransferases
Carbohydrate-based Treatment of Cancer Metastasis
N-Acetylneuraminic Acid Derivatives and Mimetics as Anti-influenza Agents
Carbohydrate-based Drug Discovery in the Battle Against Bacterial Infections
 
(partial contents)

Complex Carbohydrate Synthesis
The Chemistry of Sialic Acid
Solid-Phase Oligosaccharide Synthesis
Solution and Polymer-supported Synthesis of Carbohydrates
Enzymatic Synthesis of Oligosaccharides
Glycopeptides and Glycoproteins: Synthetic Chemistry and Biology
Chemistry and Biochemistry of Asparagine-linked Protein Glycosylation
Conformational Analysis of C-Glycosides and Related Compounds
Synthetic Lipid A Analogs for Sepsis Treatment
Polysialic Acid Vaccines
Synthetic Carbohydrate-based Vaccines
Antithrombotics Based on Synthetic Oligosaccharides
Sequencing of Oligosaccharides and Glycoproteins
Analytical Techniques for the Characterization and Sequencing of Glycosaminoglycans
Synthetic Multivalent Carbohydrate Ligands as Effectors or Inhibitors of Biological Processes
Glycosyltransferase Inhibitors
RNA-Aminoglycoside Interactions
Glycosylated Natural Products
Small Molecule Inhibitors of the Sulfotransferases
Carbohydrate-based Treatment of Cancer Metastasis
N-Acetylneuraminic Acid Derivatives and Mimetics as Anti-influenza Agents
Carbohydrate-based Drug Discovery in the Battle Against Bacterial Infections
 
(partial contents)

Über Autor(innen)

Professor Chi-Huey Wong received his B.S. and M.S. degrees from National Taiwan University, and Ph.D. in Chemistry (with George Whitesides) from Massachusetts Institute of Technology in 1982. He started his independent career as Assistant Professor of Chemistry at Texas A&M University in 1983, where he became Full Professor in 1987. He has been Professor and Ernest W. Hahn Chair in Chemistry at the Scripps Research Institute since 1989 and is also a member of the Skaggs Institute for Chemical Biology since 1996.
Professor Wong is a member of the U.S. National Academy of Sciences and the American Academy of Arts and Sciences. He is a recipient of The Searle Scholar Award in Biomedical Sciences (1985), the Presidential Young Investigator Award in Chemistry (1986), the American Chemical Society A.C. Cope Scholar Award (1993), the Roy Whistler Award of the International Carbohydrate Organization (1994), the American Chemical Society Harrison Howe Award in Chemistry (1998) and the Claude S. Hudson Award in Carbohydrate Chemistry (1999), the International Enzyme Engineering Award (1999) and the Presidential Green Chemistry Challenge Award (2000). He is a member of Academia Sinica, Taipei (1994), the American Academy of Arts and Sciences (1996) and the US National Academy of Sciences (2002). He serves as editor-in-chief of Bioorganic and Medicinal Chemistry and is an executive board member of the Tetrahedron Publications. He was head of the Frontier Research Program on Glycotechnology at RIKEN (Institute of Physical and Chemical Research, Japan) (1991-1999) and is currently a scientific advisor of the Max-Planck Institute, a board member of the U.S. National Research Council on Chemical Sciences and Technology, and is a founding scientist of Optimer Pharmaceuticals, Inc. He is author and co-author of over 450 publications, 60 patents and several books.
His current interests are in the areas of bioorganic and synthetic chemistry and biocatalysis, including development of new synthetic chemistry based on enzymatic and chemo-enzymatic reactions, synthetic approach to carbohydrate-mediated biological recognition, design and synthesis of mechanism-based inhibitors of enzymes, RNA and carbohydrate receptors, development of oligosaccharide and aminoglycoside microarrays for high-throughput screening and the study of reaction mechanisms.