Epigenetic Regulation in Overcoming Chemoresistance

Volume 16
Erscheinungsjahr 2021
ISBN: 978-0-12-823684-0
Verlag: Elsevier Health Sciences

Buch, Englisch, 144 Seiten, Format (B × H): 191 mm x 235 mm, Gewicht: 450 g

Epigenetic Regulation in Overcoming Chemoresistance, Volume 19, explains how epigenetic agents can enhance the chemotherapy sensitivity of diverse types of cancers. The book provides a comprehensive delineation and the recent development of the scientific studies on the epigenetic regulation in enhancing chemo-sensitivity. In addition, it discusses several topics such as DNA methyltransferase inhibitors (DNMTi), Histone deacetylases inhibitors (HDACi), Histone lysine demethylases inhibitors (HDMi), Histone lysine methyltransferases inhibitors (HMTi) and drugs regulating the microRNA, long non-coding RNA (lncRNA) or RNA methylation. Finally, recent and future developments of the field of epigenetic regulation are explored.

This is a valuable resource for cancer researchers, clinicians, graduate students and several members of biomedical field who are interested in learning about epigenetic regulation methods to reverse chemo-resistance in cancers.

Autoren/Hrsg.

Wu, Chunfu

Wang, Lihui

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Chemotherapie

Inhaltsverzeichnis

1. The role of epigenetic regulation in cancer2. DNA methyltransferase inhibitors (DNMTi) as sensitizing agents to overcome chemoresistance3. Histone deacetylases inhibitors (HDACi) as sensitizing agents to overcome chemoresistance4. Histone lysine demethylases inhibitors (HDMi) as sensitizing agents to overcome chemoresistance5. Histone lysine methyltransferases inhibitors (HMTi) as sensitizing agents to overcome chemoresistance6. Drugs regulating the microRNA to overcome chemoresistance7. Drugs regulating the lncRNA to overcome chemoresistance8. Drugs regulating the mRNA methylation to overcome chemoresistance9. Future combined epigenetic therapy

Über Autor(innen)

Wang, Lihui
Lihui Wang, PhD, obtained his PhD in Pharmacology from Shenyang Pharmaceutical University in 2006. After that, Dr Wang started his investigation in the same institute, where he was promoted to full professor in 2018. From 2016 spring to 2017 summer, Dr. Wang majors in anti-cancer drug researches and went to Memorial Sloan Kettering Cancer Center in New York as a visiting investigator. Dr. Wang has published more than 20 papers, as first or corresponding author, in international peer reviewed journals, and his research focus is anti-cancer drugs development and chemo-sensitization.