Advances in Immunology

1. Auflage 2003
ISBN: 978-0-08-054830-2
Verlag: Elsevier Science & Techn.
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, Band Volume 81, 388 Seiten, Web PDF

Reihe: Advances in Immunology

Volume 81 of Advances in Immunology contains articles on a vast range of immunology topics including the regulation of the immune response by the interaction of chemokines and proteases as well as roles of the Semaphorin Family in immune regulation. It has a chapter devoted to B Lymphoid Neoplasms of Mice and another on the Zebrafish as a model organism to study development of the immune system. This volume will be of interest to immunologists in all industries. - Edited by a new editor, Frederick W. Alt - Covers molecular mechanisms of host-pathogen interaction - Discusses prions and the immune system

Autoren/Hrsg.

Inhaltsverzeichnis

1;Cover;1
2;Contents;6
3;Contributors;10
4;Foreword;14
5;Chapter 1. Regulation of the Immune Response by the Interaction of Chemokines and Proteases;18
5.1;I. Introduction to Chemokines;18
5.2;II. Posttranslational Modification of CXC Chemokines;30
5.3;III. CC Chemokines as Protease Substrates;37
5.4;IV. The CD26-Chemokine Connection;40
5.5;References;49
6;Chapter 2. Molecular Mechanisms of Host–Pathogen Interaction: Entry and Survival of Mycobacteria in Macrophages;62
6.1;I. Introduction;62
6.2;II. Innate Recognition of Pathogens;68
6.3;III. Phagocytosis and Intracellular Trafficking in Macrophages;74
6.4;IV. Intracellular Survival of Bacterial Pathogens;82
6.5;V. Mycobacterial Infection;87
6.6;VI. Conclusions;101
6.7;References;102
7;Chapter 3. B Lymphoid Neoplasms of Mice: Characteristics of Naturally Occurring and Engineered Diseases and Relationships to Human Disorders;114
7.1;I. Introduction;114
7.2;II. Classification of Mouse B Cell-lineage Lymphomas;119
7.3;III. Pathogenesis of Spontaneous B Cell-lineage Neoplasms;126
7.4;IV. Conclusions;133
7.5;References;133
8;Chapter 4. Prions and the Immune System: A Journey Through Gut, Spleen, and Nerves;140
8.1;I. Prion Biology: Some Basic Facts;140
8.2;II. Peripheral Entry Sites of Prions: Complicity of Immune Cells;145
8.3;III. Lymphocytes and Prion Pathogenesis;151
8.4;IV. Prion Hideouts in Lymphoid Organs;154
8.5;V. A Spleen is not a Lymph Node: Idiosyncrasies in the Lymphotropism of Prions;158
8.6;VI. Sympathetic Nerves: A Neuroimmune Link?;160
8.7;VII. Innate Immunity and Antiprion Defense;165
8.8;VIII. Adaptive Immunity and Pre-Exposure Prophylaxis Against Prions;167
8.9;IX. The Prion Doppelganger;170
8.10;X. Prion Immunology: Quo Vadis?;175
8.11;XI. An Essential Glossary of Prion Jargon;176
8.12;References;177
9;Chapter 5. Roles of the Semaphorin Family in Immune Regulation;190
9.1;I. Overview;190
9.2;II. Class IV Semaphorin (1): CD100/Sema4D;194
9.3;III. Class IV Semaphorin (2): Sema4A;204
9.4;IV. Virus-Encoded Semaphorins and their Cellular Counterparts;208
9.5;V. Class III Semaphorin: Sema3A in Immune Cell Migration;209
9.6;VI. Neuropilin-1 in initial T cell/DC Contacts;210
9.7;VII. Perspectives;211
9.8;References;212
10;Chapter 6. HLA-G Molecules: from Maternal–Fetal Tolerance to Tissue Acceptance;216
10.1;I. Introduction;216
10.2;II. The HLA-G Gene and Polymorphism;218
10.3;III. Regulation of HLA-G Gene Expression;223
10.4;IV. Processing and Transport of HLA-G Molecules;230
10.5;V. Structural and Functional Properties of HLA-G Molecules;234
10.6;VI. Role of HLA-G in Normal and Pathological Pregnancies;242
10.7;VII. HLA-G in Organ Transplantation;249
10.8;VIII. HLA-G in Malignancies;253
10.9;References;260
11;Chapter 7. The Zebrafish as a Model Organism to Study Development of the Immune System;270
11.1;I. Introduction;270
11.2;II. Innate Immunity of Teleosts;274
11.3;III. Ontogeny of Adaptive Immunity from Fishes to Mammals;289
11.4;IV. Phenotypic Characterization of Zebrafish Hematolymphoid Cells;307
11.5;V. The Zebrafish as a Vertebrate Model System for Forward Genetic Screens;313
11.6;VI. Zebrafish Screens for Lymphoid Mutants;323
11.7;VII. Reverse Genetic Approaches;324
11.8;VIII. Gene Expression Screens;328
11.9;IX. Use of Genomics: Getting Started with the Zebrafish;330
11.10;X. Concluding Remarks: Impact of Zebrafish on Immunology;332
11.11;References;333
12;Chapter 8. Control of Autoimmunity by Naturally Arising Regulatory CD4+ T Cells;348
12.1;I. Introduction;348
12.2;II. Key Roles of Naturally Arising CD4+ Treg Cells in the Maintenance of Natural Self-Tolerance: Induction of Autoimmune Disease in Normal Animals by their Depletion;350
12.3;III. The Phenotype of Naturally Arising CD4+ Treg Cells;355
12.4;IV. Functional Characteristics of CD25+CD4+ Treg Ex Vivo and In Vitro;359
12.5;V. Molecular Basis of Treg Functions;362
12.6;VI. The Development, Specificity, and Homeostasis of CD4+ Treg Cells;369
12.7;VII. Concluding Remarks;381
12.8;References;382
13;Index;390
14;Contents of Recent Volumes;402
15;Color Plate Section;406