Handbook of Mitochondrial Dysfunction

1. Auflage 2021
ISBN: 978-1-032-17800-4
Verlag: CRC Press

Buch, Englisch, 504 Seiten, Format (B × H): 210 mm x 280 mm, Gewicht: 1220 g

Mitochondria produce the chemical energy necessary for eukaryotic cell functions; hence mitochondria are an essential component of health, playing roles in both disease and aging. More than 80 human diseases and syndromes are associated with mitochondrial dysfunction; this book focuses upon diseases linked to these ubiquitous organelles. Accumulation of mitochondrial DNA damage results in mitochondrial dysfunction through two main pathways. Mutation in mitochondrial DNA causes diseases such as Kearns-Sayre syndrome and Pearson syndrome. Mutation in chromosomal DNA causes diseases such as Parkinson's disease and schizophrenia. These and many other diseases are reviewed in this book.

Key Features

- Presents the detailed structure of mitochondria, mitochondrial function, roles of oxidants and antioxidants in mitochondrial dysfunction.

- Includes summary of both causes and effects of these diseases.

- Discusses current and potential future therapies for mitochondrial dysfunction diseases

- Explores a wide variety of diseases caused by dysfunctional mitochondria.

Autoren/Hrsg.

Ahmad, Shamim I.

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie
• Naturwissenschaften Biowissenschaften Molekularbiologie
• Naturwissenschaften Biowissenschaften Biowissenschaften
• Naturwissenschaften Biowissenschaften Zellbiologie

Inhaltsverzeichnis

ContentsPreface. xiAcknowledgment. xiiiAbout the Editor. xvContributors. xviiSECTION I Introduction: Structure and Function of MitochondriaChapter 1 Mitochondrial Structure and Function. 3Marcos Roberto de OliveiraChapter 2 Structure, Function and Evolutionary Aspects of Mitochondria. 9Puja Agarwal, Mehali Mitra, and Sujit RoyChapter 3 Mitochondrial Genome Damage, Dysfunction and Repair.23Kalyan Mahapatra, Sayanti De, and Sujit RoySECTION II Mitochondrial Dysfunction and DiseasesChapter 4 Instability of Human Mitochondrial DNA, Nuclear Genes and Diseases.39Katarzyna TonskaChapter 5 Kearns-Sayre Syndrome.55Josef FinstererChapter 6 Mitochondrial Dysfunction and Barth Syndrome.61Arianna F. Anzmann, Steven M. Claypool, and Hilary VernonChapter 7 Mitochondrial Dysfunction in the Pathophysiology of Alzheimer’s Disease.79Isaac G. OnyangoChapter 8 Mitochondrial Dysfunction in Multiple Sclerosis.87Angela Dziedzic, Elzbieta Miller, Joanna Saluk-Bijak, and Michal BijakChapter 9 Mitochondrial Dysfunction in Chronic Kidney Disease.93Maria V. Irazabal and Alfonso EirinChapter 10 Mitochondrial Dysfunction in Breast Cancer: A Potential Target from the Bench to ClinicalTherapeutics.103Thalita Basso Scandolara, Letícia Madureira Pacholak, Thayse Fachin Cormanique, Rodrigo Kern,and Carolina PanisChapter 11 Mitochondrial Dysfunction and DNA Methylation in Atherosclerosis.115Silvio Zaina and Gertrud LundChapter 12 Mitochondrial Dysfunction and Heart Diseases.127Dao-Fu DaiChapter 13 The Role of Mitochondrial Dysfunction in Mitophagy and Apoptosis and Its Relevance to Cancer.143Jan JežekChapter 14 Mitochondrial Dysfunction Linking Obesity and Asthma.151Naveen K. Bhatraju and Anurag AgrawalChapter 15 Mitochondrial Dysfunction and Hearing Loss.163María de la Luz Arenas SordoChapter 16 Superoxide Dismutase, Mitochondrial Dysfunction, and Neurodegenerative Diseases.171Jahaun Azadmanesh and Gloria E. O. BorgstahlChapter 17 Role of Post-Translational Modifications of Mitochondrial Complex I in Mitochondrial Dysfunctionand Human Brain Pathologies.191Vismaya, Yogachar Chithra, and Muchukunte Mukunda Srinivas BharathChapter 18 Heme Oxygenase-1 in Kidney Health and Disease: Perspective of Mitochondrial Homeostasis.205Pu Duann, Elias A. Lianos, and Pei-Hui LinChapter 19 Mitochondrial Transplantation in Myocardial Ischemia and Reperfusion Injury.217David Blitzer, Borami Shin, Alvise Guariento, Pedro J. del Nido, and James D. McCullyChapter 20 Mitochondrial Dysfunction in Diabetes.231Eric L. JohnsonChapter 21 Clinical Manifestation of Mitochondrial Disorders in Childhood.243Martin MagnerChapter 22 Mitochondrial Dysfunction and Epilepsies.265Bindu Parayil Sankaran and Arun B. TalyChapter 23 Mitochondrial Dysfunction and Allergic Disease.277Kritika Khanna and Anurag AgrawalSECTION III Factors Affecting Mitochondrial FunctionChapter 24 Role of Carnosic Acid in Protection of Brain Mitochondria.293Marcos Roberto de OliveiraChapter 25 Mitochondrial Dysfunction and Its Impact on Oxidative Capacity of Muscle.309Teet SeeneChapter 26 The Effects of Resveratrol on the Brain Mitochondria.319Marcos Roberto de OliveiraChapter 27 Pathophysiology and Biomarkers of Mitochondrial Dysfunction Induced by Heavy Exercise.335Sergej M. OstojicChapter 28 Mitochondrial Pathologies and Their Neuromuscular Manifestations.341Carlos Ortez and Andrés NascimentoChapter 29 Mitochondrial Stress and Cellular Senescence.361Irene L. Tan and Michael C. VelardeChapter 30 Role of Mitochondrial Dysfunction in Human Obesity.379David Albuquerque, Sara Silva, Daniel Álvarez-Vaca, Célia Aveleira, and Clévio NóbregaChapter 31 Roles of Melatonin in Maintaining Mitochondrial Welfare: Focus on Renal Cells.389Feres José Mocayar Marón, Emiliano Diez, Russel J. Reiter, and Walter ManuchaChapter 32 Mitochondrial Dysfunction Affecting the Peripheral Nervous System in Diabetic Neuropathyand Avenues for Therapy.399Jennifer Jossart, Taylor N. Dennis, and J. Jefferson P. PerryChapter 33 Mitochondrial Dysfunction and Oxidative Stress in the Pathogenesis of Metabolic Syndrome.409Qiaozhu Su and Hao WangSECTION IV Immunity and ToxicityChapter 34 Regulation of Antiviral Immunity by Mitochondrial Dynamics.425Mohsin Khan, Hasan Imam, and Saiful Anam MirChapter 35 Mitochondrial Dysfunction, Immune Systems, Their Diseases, and Possible Treatments.443Elise Jacquin, Eric Hervouet, and Michaël Boyer-GuittautChapter 36 Organophosphorus Compound-Induced Mitochondrial Disruption.461Alan J. HargreavesChapter 37 Mitochondrial Dysfunction in Friedreich Ataxia.471Rosella Abeti, Annalisa Baccaro, and Paola GiuntiIndex.477

Über Autor(innen)

Shamim I. Ahmad earned his

Master’s degree in Botany from

Patna University, Bihar, India, and

his PhD in Molecular Genetics

from Leicester University, England.

He then joined Nottingham

Polytechnic as a grade 1 lecturer and subsequently was

promoted to the post of Senior Lecturer. Ahmad now

spends much of his time producing/writing medical

books. For more than three decades he researched different

areas of molecular biology/genetics including thymineless

death in bacteria, genetic control of nucleotide

catabolism, development of anti-AIDs drug, control of

microbial infection of burns, phages of thermophilic bacteria,

and microbial flora of Chernobyl after the nuclear

power station accident. But his main interest is DNA

damage and repair specifically by near-ultraviolet light

mostly through the photolysis of biological compounds,

production of reactive oxygen species, and their implications

on human health including skin cancer. He also

investigates near-ultraviolet photolysis of non-biological

compounds such as 8-metoxypsoralen, mitomycin C, and

their importance in psoriasis treatment and in Fanconi

anemia. He has collaborated with the University of

Osaka, Japan, and he and his colleagues were able to

show that a number of naturally occurring enzymes were

able to scavenge the reactive oxygen species.

In 2003 he received a prestigious Asian Jewel Award

in Britain for Excellence in Education. His long time ambition

to produce medical books started in 2007 and since

then he has published Molecular mechanisms of Fanconi

Anemia, Molecular Mechanisms of Xeroderma Pigmentosum;

Molecular Mechanisms of Cockayne Syndrome;

Molecular Mechanisms of Ataxia Telangiectasia; Diseases

of DNA repair; Neurodegenerative diseases; Diabetes: an

Old Disease a New Insight, Obesity: a Practical Guide,

Thyroid: Basic Science and Clinical Practice, and Ultraviolet

light in Human Health, diseases and environment; also

as a co-author the book on Diabetes: A comprehensive

Treatise for patients and Caregivers. His most recent books

are Reactive Oxygen Species in Biology and Human Health

and Aging: Exploring a Complex Phenomenon.