Body-On-A-Chip

Essentials and Applications
Erscheinungsjahr 2026
ISBN: 978-0-443-16110-0
Verlag: Elsevier Science

Buch, Englisch, 644 Seiten, Format (B × H): 216 mm x 276 mm, Gewicht: 450 g

Body-on-a-Chip: Essentials and Applications provides the reader high-quality information, in a single resource, that is necessary to explore the use of BOC systems from design and development to testing and personalized medicine, to medical research and diagnostics. BOC systems can recapitulate native tissue/ organ architecture, diffusion kinetics of drugs physiological flow conditions etc., similar to what would happen in the body, they are particularly powerful in predicting human efficacy prior to clinical testing of a drug, determining potential toxicity, or in clinical studies to test underlying mechanisms or action or adverse effects. With recent advancements in high-throughput analysis systems and artificial intelligence, it has also become possible to screen several drugs at a time.

Autoren/Hrsg.

Atala, Anthony

Zhang, J. Shrike

Fachgebiete

• Naturwissenschaften Biowissenschaften Biowissenschaften

Inhaltsverzeichnis

1. The Concept of Organ-on-a-Chip and Body-on-a-Chip Devices 2. Advances in Three-Dimensional Cell Culture 3. Organoids and Spheroids 4. Microfluidics 5. Materials for fabricating Micro-physiological Systems 6. Design and Engineering of Multi-organ Systems 7. Recent Trends in Microfluidic Platforms for Body-on-a-chip systems 8. Chapter Microfabrication Techniques for Making Organ-on-a-Chip and Body-on-a-Chip Devices 9. Combining 3D bioprinting with organ-on-a-chip technology 10. Incorporating Biological Components within Organ-on-a-Chip and Body-on-a-Chip Systems 11. On-chip Sensing and Data Analysis from Multi-organ Systems 12. Liver-on-a-chip 13. Lung-on-a-chip 14. Lung-on-a-chip As a Model for Studying Effects of Cigarette Smoke 15. Kidney-on-a-chip 16. Adrenals-on-a-Chip 17. Heart-on-a-chip 18. Pancreas-on-a-Chip 19. Spleen-on-a-Chip 20. Skin-on-a-Chip 21. Blood Vessels-on-a-Chip 22. Bone-on-a-Chip 23. Cartilage-on-a-Chip 24. Muscle-on-a-Chip 25. Bladder-on-a-Chip 26. Testis-on-a-Chip 27. Ovary-on-a-chip 28. Thyroid-on-a-Chip 29. Thymus-on-a-Chip 30. Brain-on-a-Chip 31. Salivary glands-on-a-Chip 32. Bone marrow on a Chip 33. Human Organ-on-a-Chip Models for Diseases 34. Cancer-on-a-Chip 35. Modeling Disease Pathogenesis Using Organ-on-a-chip Platforms 36. Organ-on-a-chip using stem cells 37. Role of Body-on-a-chip Technology in Drug Discovery and Development 38. Computational Pharmacokinetic Modeling of Body-on-chip Devices 39. Drug and Toxicity Screening Using Multi-organ Systems 40. Micro-physiological Systems for Screening Environmental Toxins and Pollutants 41. Challenges in Manufacturing and Commercial Use of Body-on-a-chip and other Micro-physiological Devices 42. Body-on-chip Devices and the Regulatory Agencies 43. Body-on-chip Systems and Clinical Biomarkers Discovery 44. Body-on-chip Systems and chemical agents 45. Body-on-chip Systems and viral agents 46. Body-on-chip Systems and omics 47. Body-on-chip Systems and artificial intelligence- pathways for the future

Über Autor(innen)

Atala, Anthony
Anthony Atala, MD, is the G. Link Professor and Director of the Wake Forest Institute for Regenerative Medicine. Seventeen of his lab’s technologies have been translated to patients, including the first tissue-engineered organ for permanent implantation in a human. His research led to the discovery of a multipotent source of stem cells from amniotic fluid and placenta, advances in 3D printing of tissues and organs, and body-on-a-chip technologies. His work was twice listed among Time Magazine’s top 10 medical breakthroughs of the year, and he is a recipient of the Smithsonian Ingenuity Award. He has published over 900 journal articles, is the editor of 25 books, and holds over 250 national and international patents. Dr. Atala is a member of the National Academy of Medicine, the National Academy of Inventors, and the American Institute for Medical and Biological Engineering.

Zhang, J. Shrike
Dr. Zhang's research interests include 3D bioprinting, organ-on-a-chip, biomaterials, regenerative engineering, and bioanalysis. His scientific contributions have been recognized by over 40 regional, national, and international awards. He has been invited to deliver more than 170 lectures worldwide and has served as reviewer for more than 700 manuscripts for as many as 60 journals. He is serving as Editor-in-Chief for Microphysiological Systems and is Associate Editor for Bio-Design and Manufacturing, Nano Select, Aggregate, Nano TransMed, and Essays in Biochemistry. He is also on the Editorial Board of Biofabrication, Bioprinting, Advanced Healthcare Materials, Regenerative Biomaterials, Discover Materials, BMC Biomedical Engineering, Materials Today Bio, Bioengineering, Pharmaceutics, Materials Futures, Biomedical Engineering and Computational Biology, International Journal of Bioprinting, and Chinese Chemical Letters, Editorial Advisory Board of Biomicrofluidics, International Advisory Board of Advanced NanoBiomed Research and Advanced Materials Technologies, and Advisory Panel of Nanotechnology. At leisure (if any), Dr. Zhang enjoys bird- and nature-watching, traveling, photography, and technology