Banga Transdermal and Intradermal Delivery of Therapeutic Agents

Application of Physical Technologies
Erscheinungsjahr 2011
ISBN: 978-1-4398-0510-7
Verlag: Taylor & Francis
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 309 Seiten

Skin, once thought to be an impenetrable barrier, is an extremely active organ capable of interacting with its environment. Advancements in science combined with the need for diverse drug delivery modalities have introduced a variety of transdermal and intradermal products for existing drugs at a fraction of the cost of new drug development. Commercialization of transdermal drug delivery requires technology from many disciplines beyond pharmaceutical sciences, such as polymer chemistry, adhesion sciences, mass transport, web film coating, printing, and medical technology.

A comprehensive discussion of these technologies and practices, Transdermal and Intradermal Delivery of Therapeutic Agents: Application of Physical Technologies covers:

- Commercial development of devices and products based on transdermal physical enhancement technologies

- Selecting optimal enhancement technology for a specific drug molecule using case studies

- Physicochemical properties and practical commercial considerations related to cost, unmet clinical needs, marketing, or intellectual property protection

- Technologies such as microneedles, iontophoresis, electroporation, and sonophoresis, with examples for delivery of small molecules, cosmeceuticals, proteins, and vaccines

- Practical information on experimental procedures and challenges related to skin irritation and safety issues

Up-to-date and accessible to researchers and industry experts, this book provides a comprehensive discussion of the physical approaches and practical considerations for the laboratory and marketplace.

Zielgruppe

Researchers in the pharmaceutical, biotechnology, and chemical industries; colleges of pharmacy, medical colleges, and chemical engineering and bioengineering departments; and students enrolled in drug delivery courses.

Autoren/Hrsg.

Banga, Ajay K

Fachgebiete

• Naturwissenschaften Chemie Chemie Allgemein
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Pharmazie
• Technische Wissenschaften Maschinenbau | Werkstoffkunde Technische Mechanik | Werkstoffkunde

Inhaltsverzeichnis

Percutaneous Absorption and Enhancement Strategies
Structure and Enzymatic Activity of the Skin
Percutaneous Absorption
Passive Permeation Enhancement Strategies
Active Enhancement Strategies for Percutaneous Absorption

Experimental Methods and Tools for Transdermal Delivery by Physical Enhancement Methods
Considerations in Selecting the Skin Model
Transdermal Studies
Tape Stripping and Microdialysis
Instrumental Tools Used to Characterize Transdermal Transport

Microporation-Mediated Transdermal Drug Delivery
Skin Microporation by Microneedles
Skin Microporation by Other Approaches
Combination Approaches
Applications of Microporation

Iontophoretic Intradermal and Transdermal Drug Delivery
Electrical Properties of Skin
Pathways of Iontophoretic Drug Delivery
Theoretical Basis of Iontophoresis
Factors Affecting Iontophoretic Delivery
pH Control in Iontophoresis Research
Electroosmotic Flow
Reverse Iontophoresis
Treatment Protocols and Formulations
Combined Use of Iontophoresis and Other Enhancement Techniques
Applications of Iontophoresis
Clinical Applications of Iontophoresis for Intradermal Delivery

Skin Electroporation and Its Applications
Electropermeabilization of the Skin
Electroporation Equipment
Factors Affecting Delivery by Electroporation
Skin Toxicology of Electroporation
Electroporation for Cancer Chemotherapy
Delivery of Drugs by Electroporation

Sonophoresis for Intradermal and Transdermal Drug Delivery
Factors Affecting Sonophoresis
Mechanisms of Ultrasound-Mediated Transdermal Delivery
Delivery of Lipophilic Drugs
Sonophoresis Devices
Skin Irritation and Electrical Properties
Transdermal Delivery Application of Sonophoresis
Combination Approaches

How to Go about Selecting the Optimal Enhancement Method for Transdermal Delivery of a Specific Drug Molecule: Case Studies
Introduction
Technology Comparison and Limitations
Passive versus Active Patches for Transdermal and Intradermal Delivery
Case Studies

Transdermal Delivery of Peptides and Proteins
Structural Considerations of Polypeptides Relevant to Transdermal Delivery
Protease Inhibitors and Permeation Enhancers for Transdermal Protein Delivery
Iontophoretic Delivery of Peptides
Transdermal Delivery of Peptides and Proteins: Examples

Transcutaneous Immunization via Physical Methods
Immunology of the Skin
Transcutaneous Immunization by Passive Approaches
Microneedle-Based Intradermal Injection
Microneedle-Mediated Vaccination
Jet Injectors
Delivery of DNA Vaccines, Genes, and Oligonucleotides

Commercial Development of Devices and Products for Transdermal Physical Enhancement Technologies
What Can Be Learned from the Passive Patches on the Market?
Safety Issues and Effect of Heat
Skin Irritation Testing
Commercial Development of Microporation Devices
Commercial Development of Iontophoretic Devices
Formulation Considerations
Patch Design and Regulatory Issues
Dose and Bioavailability

Über Autor(innen)

Dr. Ajay K. Banga is Professor and Department Chair in the Department of Pharmaceutical Sciences at the College of Pharmacy and Health Sciences, Mercer University, Atlanta, Georgia. He also holds an Endowed Chair in transdermal delivery systems. His research expertise is in non-traditional approaches for transdermal drug delivery, especially for water soluble drugs including small conventional molecules and macromolecules. Dr. Banga has a Ph.D. in pharmaceutics from Rutgers University, New Jersey.
Dr. Banga has over 220 publications and scientific abstracts to his credit. His laboratory is funded by several start up and leading pharmaceutical companies. Dr. Banga currently serves on the Editorial Board of 7 journals, as Associate Editor for one journal, and has served as the Editor-in-Chief (2002-07) for a drug delivery journal. He has written two books in the areas of delivery of proteins and transdermal delivery. He has served on over 30 thesis/dissertation advisory committees and as a referee for over 28 journals. He is a Fellow of the American Association of Pharmaceutical Scientists.