Study on the Cellular Regulation and Function of Lysine Malonylation, Glutarylation and Crotonylation

1. Auflage 2020
ISBN: 978-981-15-2511-7
Verlag: Springer Nature Singapore

Buch, Englisch, 163 Seiten, Format (B × H): 155 mm x 235 mm, Gewicht: 289 g

Reihe: Springer Theses

This book presents pioneering findings on the characterization of cellular regulation and function for three recently identified protein posttranslational modifications (PTMs): lysine malonylation (Kmal), glutarylation (Kglu) and crotonylation (Kcr). It addresses three main topics: (i) Detecting Kmal substrates using a chemical reporter, which provides important information regarding the complex cellular networks modulated by Kmal; (ii) Identifying Kglu as a new histone PTM and assessing the direct impact of histone Kglu on chromatin structure and dynamics; and (iii) Revealing Sirt3’s value as a regulating enzyme for histone Kcr dynamics and gene transcription, which opens new avenues for examining the physiological significance of histone Kcr. Taken together, these studies provide information critical to understanding how these protein PTMs are associated with various human diseases, and to identifying therapeutic targets for the dysregulation of these novel protein markers in varioushuman diseases.

Zielgruppe

Research

Autoren/Hrsg.

Bao, Xiucong

Fachgebiete

• Naturwissenschaften Biowissenschaften Zellbiologie
• Naturwissenschaften Chemie Organische Chemie Biochemie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Humangenetik
• Naturwissenschaften Biowissenschaften Proteinforschung

Inhaltsverzeichnis

Introduction to Protein Posttranslational Modifications (PTMs).- Chemical reporter for Lysine Malonylation.- Identification of Histone Lysine Glutarylation.- Glutarylation at Histone H4 lysine 91 Modulates Chromatin Assembly.- Identification of Sirt3 as an ‘Eraser’ for Histone Lysine Crotonylation Marks using a Chemical Proteomics Approach.