Barrett / Fletcher / Wilton Untranslated Gene Regions and Other Non-coding Elements

Regulation of Eukaryotic Gene Expression
2013
ISBN: 978-3-0348-0679-4
Verlag: Springer
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 56 Seiten, eBook

Reihe: SpringerBriefs in Biochemistry and Molecular Biology

There is now compelling evidence that the complexity of higher organisms correlates with the relative amount of non-coding RNA rather than the number of protein-coding genes. Previously dismissed as “junk DNA”, it is the non-coding regions of the genome that are responsible for regulation, facilitating complex temporal and spatial gene expression through the combinatorial effect of numerous mechanisms and interactions working together to fine-tune gene expression. The major regions involved in regulation of a particular gene are the 5’ and 3’ untranslated regions and introns. In addition, pervasive transcription of complex genomes produces a variety of non-coding transcripts that interact with these regions and contribute to regulation. This book discusses recent insights into the regulatory roles of the untranslated gene regions and non-coding RNAs in the control of complex gene expression, as well as the implications of this in terms of organism complexity and evolution.

Zielgruppe

Research

Autoren/Hrsg.

Barrett, Lucy W.

Fletcher, Sue

Wilton, Steve D.

Inhaltsverzeichnis

Introduction.- Promoter.- 5’ Untranslated Region.- Structure.- Intronic Regions.- 3’ Untranslated Region.- Non-coding RNAs.- Conclusion.