Bergethon The Physical Basis of Biochemistry

The Foundations of Molecular Biophysics
Erscheinungsjahr 2013
ISBN: 978-1-4757-2963-4
Verlag: Springer US
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 567 Seiten, Web PDF

The objective of this book is to provide a unifying approach to the study of biophysical chemistry for the advanced undergraduate who has had a year of physics, organic chem istry, calculus, and biology. This book began as a revised edition of Biophysical Chemistry: Molecules to Membranes, which Elizabeth Simons and I coauthored. That short volume was written in an attempt to provide a concise text for a one-semester course in biophysical chemistry at the graduate level. The experience of teaching biophysical chemistry to bi ologically oriented students over the last decade has made it clear that the subject requires a more fundamental text that unifies the many threads of modem science: physics, chem istry, biology, mathematics, and statistics. This book represents that effort. This volume is not a treatment of modem biophysical chemistry with its rich history and many contro versies, although a book on that topic is also needed. The Physical Basis of Biochemistry is an introduction to the philosophy and practice of an interdisciplinary field in which biological systems are explored using the quantitative perspective of the physical scientist. I have three primary objectives in this volume: one, to provide a unifying picture of the interdisciplinary threads from which the tapestry of biophysical studies is woven; two, to provide an insight into the power of the modeling approach to scientific investigation; and three, to communicate a sense of excitement for the activity and wholesome argument that characterize this field of study.

Zielgruppe

Graduate

Autoren/Hrsg.

Bergethon, Peter R.

Inhaltsverzeichnis

1 Introduction to the Principles and Practice of Biophysical Chemistry.- 2 Physical Thoughts, Biological Systems: The Application of Modeling Principles to Understanding Biological Systems.- 3 Probability and Statistics.- 4 Physical Principles: Energy—The Prime Observable.- 5 Physical Principles: Mechanics and Motion.- 6 Physical Principles: Waves.- 7 Physical Principles: Electrostatics.- 8 Physical Principles: Electromagnetics.- 9 Physical Principles: Quantum Mechanics.- 10 Chemical Principles.- 11 Measuring the Energy of a System: Energetics and the First Law of Thermodynamics.- 12 The Whole Is Greater than the Sum of Its Parts: Entropy and the Second Law.- 13 Which Way Is That System Going? The Gibbs Free Energy.- 14 Friends and Neighbors—Interactions in a System: Phase Equilibria.- 15 Spectroscopy: Analysis of Structure.- 16 Analysis of Structure: Microscopy.- 17 Scenic Overlook Backward and Forward.- 18 Water: A Unique Structure, a Unique Solvent.- 19 Ion-Solvent Interactions.- 20 Ion-Ion Interactions.- 21 Lipids in Aqueous Solution: The Formation of the Cell Membrane.- 22 Constructing a Biological State Space.- 23 Macromolecules in Solution.- 24 Molecular Modeling: Mapping Biochemical State Space.- 25 The Electrified Interface.- 26 Forces Across Membranes.- 27 Transport: A Nonequilibrium Process.- 28 Flow in a Chemical Potential Field: Diffusion.- 29 Flow in an Electrical Field: Conduction.- 30 Electrokinetic Phenomena.- 31 Kinetics: Chemical Kinetics.- 32 Kinetics: Enzymes and Electrons.- Epilogue.- Appendixes.- Appendix A Mathematical Methods.- A.1 Units and Measurement.- A.2 Trigonometric Functions.- A.3 Expansion Series.- A.4 Differential and Integral Calculus.- A.4.1 Partial Differentiation.- A.5 Vectors.- A.5.1 Addition and Subtraction.- A.5.2 Magnitudeof a Vector.- A.5.3 Multiplication.- Appendix B Fictitious and Pseudoforces: The Centrifugal Force.- Appendix C The Determination of the Field from the Potential in Cartesian Coordinates.- Appendix D Hamilton’s Principle of Least Action/Fermat’s Principle of Least Time.- Appendix E Geometrical Optics.- E.1 Reflection and Refraction of Light.- E.2 Mirrors.- E.2.1 The Plane Mirror.- E.2.2 The Concave Mirror.- E.3 Image Formation by Refraction.- E.4 Prisms and Total Internal Reflection.- Appendix F Derivation of the Energy of Interaction Between Two Ions.- Appendix H Derivation of the Clausius-Clapeyron Equation.- Appendix I Derivation of the van’t Hoff Equation for Osmotic Pressure.- Appendix J Derivation of the Work to Charge and Discharge a Rigid Sphere.- Appendix K Quantum Electrodynamics.- Appendix L Adiabatic and Nonadiabatic Transitions.- Appendix M Fermi’s Golden Rule.- Physical Constants.- Answers to Selected Problems.