Bevan / Kaley / Rubanyi Flow-Dependent Regulation of Vascular Function

Erscheinungsjahr 2013
ISBN: 978-1-4614-7527-9
Verlag: Springer US
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 371 Seiten, Web PDF

Reihe: Clinical Physiology

Exactly sixty years ago Schretzenmayer provided the first experimental proof that changes in blood ftow can affect the diameter oflarge arteries. Since then, support has been growing for the idea that intraluminal blood ftow plays an important role in regulating not only the tone of blood vessels, but also their caliber and structure. Investigations of the&e phenomena have been given a strong impetus by the discovery that the endothelium can modulate the tone of underlying vascular smooth muscle via the release of a number of vasoactive substances. Investigators often diverge in their opinions regarding the nature of the vascular wall response to blood ftow and the mechanisms involved. This book is the first summary of our state of knowledge and the nature of the research carried out on ftow-related changes. Early chapters review involvement of shear-stress-dependent events in the circulation as a whole. They cover the biophysical principles of ftuid transport, the cellular signal transduction path ways, and the molecular biology and biochemistry of ftow-induced changes in endothelial cells. Later chapters provide an in-depth summary of the regula tion of vascular muscle tone by ftow. They include historical perspectives, evi dence that ftow-induced vasodilation is primarily endothelium-dependent and that it can induce constriction, and details on ftow-dependent regulation in regional vascular beds. Several chapters emphasize the endothelial activation by shear stress and its importance in the control offtow in the microcirculation.

Zielgruppe

Research

Autoren/Hrsg.

Bevan, John A

Kaley, Gabor

Rubanyi, Gabor M

Inhaltsverzeichnis

I Biophysical and Biochemical Aspects.- 1. The Design of Fluid Transport Systems: A Comparative Perspective.- 2. Shear Stress in the Circulation.- 3. Flow-Mediated Signal Transduction in Endothelial Cells.- 4. Gene Regulation in Endothelial Cells.- 5. Flow Effects on Endothelial Cell Signal Transduction, Function, and Mediator Release.- II Flow-Mediated Control of Vascular Tone.- 6. Flow-Induced Vasodilation of Large Arteries: From “Ascending Reflex” to EDRF.- 7. The Role of Flow-Induced Contraction and Relaxation in the Regulation of Vascular Tone: Results of In Vitro Studies.- 8. Coronary Microvascular Responses to Flow.- 9. Endothelium-Derived Relaxing Factor and the Control of Flow in Conduit and Resistance Arteries.- 10. Regulation of Platelet Function by Flow-Induced Release of Endothelial Autacoids.- 11. Endothelial Control of Shear Stress and Resistance in the Skeletal Muscle Microcirculation.- 12. Overview of Regulatory Mechanisms in the Microcirculation.- III Flow-Induced Remodeling and Regulation of Vascular Function in Disease States.- 13. Blood Flow-Induced Remodeling of the Artery Wall.- 14. Atherosclerosis and the Role of Wall Shear Stress.- 15. Role of EDRF/NO in Chronic High Coronary Blood Flow States During Myocardial Dysfunction and Failure.- 16. Endothelial Role in Coronary Vasospasm and Atherosclerosis.