Buch, Englisch, 79 Seiten, Format (B × H): 155 mm x 235 mm, Gewicht: 454 g
Reihe: Springer Theses
Buch, Englisch, 79 Seiten, Format (B × H): 155 mm x 235 mm, Gewicht: 454 g
Reihe: Springer Theses
ISBN: 978-3-662-54616-1
Verlag: Springer
This thesis describes the use of biophysical and biochemical methods to prove that calcium has a positive feedback effect on amplifying and sustaining CD3 phosphorylation and should enhance T-cell sensitivity to foreign antigens. The study presented shows that calcium can regulate the signal pathway in cells not only as a secondary messenger but also through direct interactions with the phospholipid bilayer. The approach used in the thesis also represents an important advance, as it couples the use of nuclear magnetic resonance (NMR) to the analysis of signaling phenomena in living cells. Moreover, the thesis optimizes the Nanodisc assembly protocol, which can broaden its range of applications in membrane protein studies. A preliminary study on the structure of dengue virus NS2B-NS3p in complex with aprotinin, which may help to develop new drugs against the dengue virus, is also included.
Zielgruppe
Research
Autoren/Hrsg.
Fachgebiete
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Medizintechnik, Biomedizintechnik, Medizinische Werkstoffe
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Immunologie
- Naturwissenschaften Biowissenschaften Angewandte Biologie Biophysik
- Naturwissenschaften Physik Quantenphysik Atom- und Molekülphysik
- Naturwissenschaften Biowissenschaften Zellbiologie
- Naturwissenschaften Physik Angewandte Physik Biophysik
- Technische Wissenschaften Sonstige Technologien | Angewandte Technik Medizintechnik, Biomedizintechnik
Weitere Infos & Material
Introduction.- Review.- Nanodisc assembly and the study on the interaction between the lipid and ion.- Calcium regulates T cell receptor activation through phospholipid electrostatic manipulation.- The preliminary study on the structure of Dengue Virus NS2B-NS3p in complex with aprotinin.- Summary and prospect of this dissertation.
