Bjorklund / Cenci-Nilsson Recent Advances in Parkinsons Disease

Part II: Translational and Clinical Research
1. Auflage 2010
ISBN: 978-0-444-53751-5
Verlag: Elsevier Science & Techn.
Format: EPUB
Kopierschutz: 6 - ePub Watermark

E-Book, Englisch, Band Volume 184, 368 Seiten

Reihe: Progress in Brain Research

This second volume follows on from Part I by reviewing the variety of animal models of PD current available (from drosophila to rodents to non-human primate species) and their specific contributions to PD research. This is followed by comprehensive coverage of functional neuroimaging studies that explore different pathophysiological questions and evaluate treatment outcome in PD patients. Different areas of experimental therapeutics and outstanding challenges to PD treatment are presented in a concluding group of articles. - Complete overview of hot topics and approaches to current PD research, from molecules, to brain circuits, to clinical and therapeutic applications - Leading authors review the state-of-the-art in their field of investigation, and provide their views and perspectives for future research - All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist

Autoren/Hrsg.

Bjorklund, Anders

Cenci-Nilsson, Angela

Inhaltsverzeichnis

1;Cover;1
2;Recent Advances in Parkinson's Disease: Translational and Clinical Research;2
3;Copyright;5
4;List of Contributors;6
5;Preface;8
6;Contents;10
7;Section I. Animal models of PD;12
8;Chapter 1. What have we learned from Drosophila models of Parkinson’s disease?;14
9;Chapter 2. Neurotoxic in vivo models of Parkinson’s disease: recent advances;28
10;Chapter 3. Behavioral analysis of motor and non-motor symptoms in rodent models of Parkinson’s disease;46
11;Chapter 4. Genetic mouse models of Parkinson’s disease: The state of the art;64
12;Chapter 5. Viral vector-mediated overexpression of a-synuclein as a progressive model ofParkinson’s disease;100
13;Chapter 6. Modeling neuroinflammatory pathogenesis of Parkinson’s disease;124
14;Chapter 7. The MPTP-lesioned non-human primate models of Parkinson’s disease. Past,present, and future;144
15;Section II. Exploring PD with brain imaging;170
16;Chapter 8. Abnormal metabolic brain networks in Parkinson’s disease: from blackboard to bedside;172
17;Chapter 9. Imaging the nigrostriatal system to monitor disease progression andtreatment-induced complications;188
18;Chapter 10. Brain imaging after neural transplantation;204
19;Chapter 11. Imaging non-motor aspects of Parkinson’s disease;216
20;Section III. Frontiers in PD treatment;230
21;Chapter 12. Gene therapy for dopamine replacement;232
22;Chapter 13. Neurotrophic factor therapy for Parkinson’s disease;248
23;Chapter 14. Neural grafting in Parkinson’s disease: problems and possibilities;276
24;Chapter 15. Neural grafting in Parkinson’s disease: unraveling the mechanisms underlyinggraft-induced dyskinesia;306
25;Chapter 16. Deep brain stimulation: state of the art and novel stimulation targets;322
26;Chapter 17. The challenge of non-motor symptoms in Parkinson’s disease;336
27;Subject Index;354