Buch, Englisch, 357 Seiten, Format (B × H): 223 mm x 288 mm, Gewicht: 1092 g
Mechanisms, Dissemination, and Prospects for Inhibition
Buch, Englisch, 357 Seiten, Format (B × H): 223 mm x 288 mm, Gewicht: 1092 g
ISBN: 978-1-55581-303-1
Verlag: ASM Press
A vital, comprehensive overview from some of the world’s leading researchers and scholars in this field. • Discusses bß-Lactamases and aminoglycoside-modifying enzymes as well as other enzymatic mechanisms that result in resistance. • Covers the different ways bacteria share resistance determinants, both vertically and horizontally. • Offers strategies to control the dissemination of resistance genes and to combat these highly versatile inactivating enzymes. • Serves as a resource for researchers working for clinical research laboratories, hospitals, medical schools, and applied and pharmaceutical research laboratories.
This title is published by the American Society for Microbiology Press and distributed by Taylor and Francis in rest of world territories.
Autoren/Hrsg.
Weitere Infos & Material
Table of Contents
A: ENZYMES IN DEFENSE OF THE BACTERIAL RIBOSOME
1. Overview of Aminoglycosides and Enzyme-Mediated Bacterial Resistance: Clinical Implications, Robert A. Bonomo
2. Aminoglycoside Antibiotics, Kanchana Majumder, Lianhu Wei, Subhash C. Annedi, and Lakshmi P. Kotra
3. Structural Aspects of Aminoglycoside-Modifying Enzymes, Gerard D. Wright and Albert M. Berghuis
4. Aminoglycoside-Modifying Enzymes: Characteristics, Localization, and Dissemination, Marcelo E. Tolmasky
5. rRNA Methylases and Resistance to Macrolide, Lincosamide, Streptogramin, Ketolide,
and Oxazolidinone (MLSKO) Antibiotics, Marilyn C. Roberts
B: ENZYMES IN DEFENSE OF THE BACTERIAL CELL WALL
6. B-Lactamases: Historical Perspectives, Karen Bush and Patricia A. Bradford
7. Resistance Mediated by Penicillin-Binding Proteins, Malcolm G. P. Page
8. Inhibition of Class A Beta-Lactamases, Samy O. Meroueh, Jooyoung Cha, and Shahriar Mobashery
9. Class Beta-Lactamases, Gian Maria Rossolini and Jean-Denis Docquier
10. Crystal Structures of Class C B-Lactamases: Mechanistic Implications and Perspectives in Drug Design, C. Bauvois and J. Wouters
11. Class D Beta-Lactamases, Franck Danel, Malcolm G. P. Page, and David M. Livermore
12. A Brief Introduction to Enzyme Kinetics, Moreno Galleni and Jean-Marie Frere
C: NOVEL APPROACHES AND FUTURE PROSPECTS
13. The Pharmaceutical Industry and Inhibitors of Bacterial Enzymes: Implications for Drug Development, David M. Shlaes, Lefa Alksne, and Steven J. Projan
14. Beta-Lactamase Inhibitory Proteins, Zhen Zhang and Timothy Palzkill
15. Active Drug Efflux in Bacteria, Jurg Dreier
D: DISSEMINATION OF ANTIBIOTIC RESISTANCE AND ITS BIOLOGICAL COST
16. Overview of Dissemination Mechanisms of Genes Coding for Resistance to Antibiotics, Marcelo E. Tolmasky
17. Conjugative Transposons, Louis B. Rice
18. The Dissemination of Antibiotic Resistance by Bacterial Conjugation, Virginia L. Waters
19. Bacterial Toxin-Antitoxin Systems as Targets for the Development of Novel Antibiotics, Juan C. Alonso, Dolors Balsa, Izhack Cherny, Susanne K. Christensen, Manuel Espinosa, Djordje Francuski, Ehud Gazit, Kenn Gerdes, Ed Hitchin, M. Teresa Martin, Concepcion Nieto, Karin Overweg, Teresa Pellicer, Wolfram Saenger, Heinz Welfle, Karin Welfle, and Jerry Wells
20. Integrons and Superintegrons, Robert A. Bonomo, Andrea M. Hujer, and Kristine M. Hujer
21. The Biological Cost of Antibiotic Resistance, Dan I. Andersson, Sophie Maisnier Patin, Annika I. Nilsson, and Elisabeth Kugelberg
