Radiotheranostics Two Volume Set

1. Auflage 2025
ISBN: 978-1-041-14308-6
Verlag: Taylor & Francis Ltd

Buch, Englisch, 480 Seiten, Format (B × H): 178 mm x 254 mm

Reihe: Series in Medical Physics and Biomedical Engineering

The first volume addresses the Physics. Chemistry, Biology and Clinical Applications of Radiotheranostics.

This book covers scientific, clinical, and educational aspects of radiotheranostics in cancer control. Setting the framework, the first volume defines radiotheranostics and describes the history of radionuclide therapy and theranostics, and the biology of cancer. It examines the clinical applications of unconjugated radionuclides, such as ¹³¹I and ²²³Ra, and of radionuclide-conjugated cancer-specific vectors: peptides, small molecules, antibodies, and nanoparticles; introduces clinical trials and drug development; and reviews epidemiological studies and the adverse effects of radionuclide therapy – both radiation injuries and chemical toxicity. It presents the chemistry and physics of radionuclide production, discusses radioactivity measurements and traceability, and addresses important instrumentation aspects: calibration, quantitative imaging, and quality control. Volume I concludes with guidance on the education, training, and competence of a radiotheranostic multidisciplinary team and summarizes the principal physics characteristics of theranostics today – including many to be expanded in the second volume – while offering a glimpse into tomorrow. This volume provides the foundations for the more advanced second volume, which explores dosimetric and radiation safety, aiming to empower medical physicists and demonstrate to the cancer community how to improve cancer control and yield increased patient survival times.It will be a valuable reference for medical and health physicists with basic knowledge of nuclear medicine.

The second volume covers Radiation Chemistry, Radiation biology, Dosimetry, Safety, Economics and Artificial Intelligence aspects of Radiotheranostics.

The book expands upon the radiotheranostic topics in cancer care covered in Volume I, which includes cancer biology, clinical applications, radionuclide production, source calibration, imaging instrume

Zielgruppe

Postgraduate, Professional Reference, and Professional Training

Autoren/Hrsg.

Borras, Cari

Borrás, Cari

Stabin, Michael G.

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Bildgebende Verfahren, Nuklearmedizin, Strahlentherapie Radiologie, Bildgebende Verfahren
• Naturwissenschaften Physik Angewandte Physik Medizinische Physik
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Medizinische Diagnose und Diagnostik
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Onkologie, Krebsforschung
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Pflege Fachpflege
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Bildgebende Verfahren, Nuklearmedizin, Strahlentherapie Nuklearmedizin, PET, Radiotherapie

Inhaltsverzeichnis

Volume One

List of Common Acronyms

Part 1 – Introduction

Chapter 1 What is radiotheranostics?

Chapter 2 History of radionuclide therapy and theranostics

Chapter 3 Biological principles behind targeted radionuclide therapy for cancer

Part 2 – Clinical Applications of Targeted Radionuclide Therapy in Cancer Control

Chapter 4 Unconjugated radionuclides

Chapter 5 Radionuclide-conjugated cancer-specific vectors: Peptides

Chapter 6 Radionuclide-conjugated cancer-specific vectors: Small Molecules and antibodies

Chapter 7 Radionuclide-conjugated cancer-specific vectors: Nanoparticles

Chapter 8 Introduction to clinical trials and drug development for radionuclide therapies

Chapter 9 Epidemiologic Studies of Cancer Risk among Patients Administered Radionuclides

Chapter 10 Adverse effects of radionuclide therapy

Part 3 – Radiation Chemistry and Physics

Chapter 11 Radionuclide production

Chapter 12 Radioactivity measurement and traceability

Chapter 13 Instrumentation, calibration, quantitative imaging, and quality control

Part 4 - The Future

Chapter 14 Human resources: Multidisciplinary team education, training, and competence

Chapter 15 Theranostics today: Looking backwards to tomorrow

Volume Two

List of Common Acronyms

Part 1 – Introduction

Chapter 1. Radiotheranostics: Challenges Today

Part 2 – Radiochemistry and Radiobiology

Chapter 2. Radiopharmaceutical Preparations and Radiolabeling Strategies

Chapter 3. New Insights Into the Radiation Biology of Radiotheranostics

Chapter 4. Radiation Embryology: Human and Animal Studies

Part 3 – Particle Dosimetry

Chapter 5. Alpha- and Beta-particle Therapy and Dosimetry

Chapter 6. Auger Emitters

Chapter 7. Positrons: Their Potential Role in Radionuclide Therapy

Part 4 – Dosimetry Formalisms

Chapter 8. Biokinetic Modelling For Radionuclide Dosimetry

Chapter 9. Standardized Tumor and Organ Dosimetry

Chapter 10. Image-based Dosimetry Procedures

Chapter 11. Combining External Beam Radiotherapy and Radionuclide Therapy

Chapter 12. Uncertainties in Dose Calculations

Part 5 – Safety

Chapter 13. Design, Shielding, and Operational Radiation Safety Aspects of the Radiotheranostic Facility

Chapter 14. Management of Deceased Patients Under Treatment (Radioactive Cadavers)

Chapter 15. Radiopharmaceutical Regulatory Requirements

Part 6 – Future Directions and Opportunities

Chapter 16. The Economics of Theranostics

Chapter 17. Artificial intelligence in Radiotheranostics

Über Autor(innen)

Cari (Caridad) Borrás is a certified medical physicist in Washington, DC, USA, where she works as an international consultant and has an adjunct faculty position at the George Washington University School of Medicine and Health Sciences. She obtained a Doctor of Science (Physics) degree from the University of Barcelona, Spain, having done a thesis research project on the dosimetry and embryological effects of Astatine- 211 at Thomas Jefferson University in Philadelphia, PA, USA, as a Fulbright scholar. The American Board of Radiology certified her in Radiological Physics and the American Board of Medical Physics in Medical Health Physics. She has worked as a radiological physicist in Barcelona, Spain; Philadelphia, PA; San Francisco, CA; Recife, Brazil; and Washington, DC, where for 15 years she was responsible for the Radiological Health Program of the Pan American / World Health Organization. She has lectured in more than 300 seminars/courses/congresses, many organized by her; authored/contributed around 100 articles and six book chapters; and edited/coedited three books. She is a Fellow of ACR, AAPM, IOMP, HPS, and IUPESM, and has received awards/recognitions from SEFM, AAPM, ALFIM, IOMP, IUPESM, ACCE, ACR, and ABR.

Michael G. Stabin is a Certified Health Physicist, President of the Radiation Dose Assessment Resource, Inc., living in Kennewick, WA, USA, where he worked for NV5 – Technical Engineering & Consulting Solutions and Hanford Mission Integration Solutions. He was an Associate Professor in the Radiology and Radiological Sciences Department at Vanderbilt University, in Nashville, TN, and a Scientist at the Radiation Internal Dose Information Center of Oak Ridge Institute for Science and Education. He received a Ph.D. in Nuclear Engineering (Health Physics emphasis) from the University of Tennessee, is a member of the HPS and the SNMMI, and is also a Fulbright scholar. He has over 225 publications in the open literature, most on internal dosimetry for nuclear medicine applications, including complete textbooks on health physics and internal dose assessment.