Toxicologic Pathology

Nonclinical Safety Assessment
3rd Auflage
ISBN: 978-1-032-31919-3
Verlag: CRC Press

Buch, Englisch, 834 Seiten, Format (B × H): 213 mm x 283 mm, Gewicht: 2368 g

The new edition provides practical and timely information for toxicologic pathologists working in drug discovery and development. The introductory concept chapters are consolidated into two more concise and better-organized introductory chapters. The two concept chapters introduce the reader to pharmaceutical R&D, the role of the pathologist in the process, and critical partner scientific disciplines with whom the pathologist will collaborate. In this revision, the organ system chapters incorporate more consistent commentary and guidance on the molecular mechanism of action, human translational relevance, and regulatory impact of pathological findings as they are described in these chapters.

Key Features:

- Aids scientists in understanding spontaneously occurring and compound-related pathological findings

- Features three new well-respected scientists on the editorial team

- Includes more consistent commentary and guidance in the organ system chapters

Zielgruppe

Academic

Autoren/Hrsg.

Bouchard, Page R

Sahota, Pritam S

Wallace, Shannon

Wojcinski, Zbigniew W

Schumacher, Vanessa L

Weitere Mitwirkende

Sabio, David A.

Fachgebiete

• Naturwissenschaften Biowissenschaften Biowissenschaften
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pathologie, Cytopathologie, Histopathologie

Inhaltsverzeichnis

1. Nonclinical Safety Assessment: An Overview of Drug and Medical Device Development. 2. Toxicologic Anatomic Pathology and the Pathologist.3. Toxicologic Clinical Pathology. 4. Gastrointestinal System. 5. Hepatobiliary System and Exocrine Pancreas. 6. Respiratory System. 7. Urinary System. 8. Hematopoietic System. 9. Lymphoid System. 10. Musculoskeletal System and Teeth. 11. Cardiovascular System. 12. Endocrine System. 13. Reproductive System and Mammary Gland. 14. Integumentary System. 15. Nervous System. 16. Special Senses: Eye and Ear.

Über Autor(innen)

Page R. Bouchard is a R&D strategy consultant to the biopharmaceutical industry with a focus on advanced therapies and emerging technologies. He retired from Novartis Pharmaceuticals in 2021 where he was the Senior Vice President and Chief Scientific Officer of the Novartis Gene Therapy Unit, and prior to that the Vice President and Global Head of Preclinical Safety. Dr. Bouchard received his DVM from Tufts Veterinary School, residency training in anatomic pathology at Cornell School of Veterinary Medicine, and ACVP board certification in 1993. Dr. Bouchard has worked as a toxicologic pathologist and project team toxicologist at Searle Pharmaceuticals, Head of Preclinical Safety at Genetics Institute, Head of Pathology and Investigative Safety at Wyeth Pharmaceuticals, Head of Preclinical Safety at Millennium Pharmaceuticals, Head of Preclinical R&D at Archemix Pharmaceuticals, and finally in his leadership roles at Novartis Pharmaceuticals. Dr. Bouchard has worked across all phases of drug discovery and development, and virtually all therapeutic modalities and disease areas. He has had the privilege of working with many companies and regulatory authorities across all regions of the world. Though the focus of his career has been managing R&D strategy and project portfolio, toxicologic pathology is the scientific lens through which he has viewed the process. Dr. Bouchard has been an active member of the ACVP and STP and has served in a variety of volunteer roles for both organizations. He is passionate about continually advancing and modernizing the science and practice of anatomic and clinical pathology and challenging pathologists to adopt new tools and fully appreciate the use, context and impact of their work.

Pritam S Sahota studied for his Veterinary Medicine (BVSc) and Veterinary Pathology (MVSc and PhD) degrees at Punjab Agricultural University in India. He is a Diplomate of the American Board of Toxicology. After completing his PhD, he immigrated to the USA in 1976 and worked for D