Brandon / West Cyclic-Nucleotide Phosphodiesterases in the Central Nervous System

From Biology to Drug Discovery
1. Auflage 2014
ISBN: 978-1-118-83632-3
Verlag: John Wiley & Sons
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 400 Seiten, E-Book

Reihe: Wiley series in drug discovery and development

This book reviews advances in understanding phosphodiesteraseswithin the central nervous system and their therapeuticapplications. A range of expert authors from both academia andindustry describe these, then focus on the areas of greatestscientific and medical interest to provide more detailed coverage.Therapeutic and drug discovery applications are covered fordiseases including Alzheimer's, Parkinson's, schizophrenia,erectile dysfunction, and spinal cord injuries. There is also achapter on drug discovery tools such as in vitro assays and X-raystructures for medicinal chemistry studies.

Autoren/Hrsg.

Brandon, Nicholas J.

West, Anthony R.

Inhaltsverzeichnis

PREFACE vii
CONTRIBUTORS ix
1 PHOSPHODIESTERASES AND CYCLIC NUCLEOTIDE SIGNALING IN THECNS 1
Marco Conti and Wito Richter
2 PUTTING TOGETHER THE PIECES OF PHOSPHODIESTERASEDISTRIBUTION PATTERNS IN THE BRAIN: A JIGSAW PUZZLE OF CYCLICNUCLEOTIDE REGULATION 47
Michy P. Kelly
3 COMPARTMENTALIZATION AND REGULATION OF CYCLIC NUCLEOTIDESIGNALING IN THE CNS 59
Manuela Zaccolo and Alessandra Stangherlin
4 PHARMACOLOGICAL MANIPULATION OF CYCLIC NUCLEOTIDEPHOSPHODIESTERASE SIGNALING FOR THE TREATMENT OF NEUROLOGICAL ANDPSYCHIATRIC DISORDERS IN THE BRAIN 77
Frank S. Menniti, Niels Plath, Niels Svenstrup, and ChristopherJ. Schmidt
5 RECENT RESULTS IN PHOSPHODIESTERASE INHIBITOR DEVELOPMENTAND CNS APPLICATIONS 115
David P. Rotella
6 CRYSTAL STRUCTURES OF PHOSPHODIESTERASES AND IMPLICATION ONDISCOVERY OF INHIBITORS 145
Hengming Ke, Huanchen Wang, Mengchun Ye, and YingchunHuang
7 INHIBITION OF CYCLIC NUCLEOTIDE PHOSPHODIESTERASES TOREGULATE MEMORY 171
Han-Ting Zhang, Ying Xu, and James O'Donnell
8 EMERGING ROLE FOR PDE4 IN NEUROPSYCHIATRIC DISORDERS:TRANSLATING ADVANCES FROM GENETIC STUDIES INTO RELEVANT THERAPEUTICSTRATEGIES 211
Sandra P. Zoubovsky, Nicholas J. Brandon, and Akira Sawa
9 BEYOND ERECTILE DYSFUNCTION: UNDERSTANDING PDE5 ACTIVITY INTHE CENTRAL NERVOUS SYSTEM 223
Eva P.P. Bollen, Kris Rutten, Olga A.H. Reneerkens, Harry M.W.Steinbusch, and Jos Prickaerts
10 MOLECULAR AND CELLULAR UNDERSTANDING OF PDE10A: ADUAL-SUBSTRATE PHOSPHODIESTERASE WITH THERAPEUTIC POTENTIAL TOMODULATE BASAL GANGLIA FUNCTION 247
Erik I. Charych and Nicholas J. Brandon
11 ROLE OF CYCLIC NUCLEOTIDE SIGNALING AND PHOSPHODIESTERASEACTIVATION IN THE
MODULATION OF ELECTROPHYSIOLOGICAL ACTIVITY OF CENTRAL NEURONS269
Sarah Threlfell and Anthony R. West
12 THE ROLE OF PHOSPHODIESTERASES IN DOPAMINE SYSTEMSGOVERNING MOTIVATED BEHAVIOR 303
Gretchen L. Snyder, Joseph P. Hendrick, and AkinoriNishi
13 INHIBITION OF PHOSPHODIESTERASES AS A STRATEGY FORTREATMENT OF SPINAL CORD INJURY 353
Elena Nikulina and Marie T. Filbin
INDEX 375

Über Autor(innen)

NICHOLAS BRANDON works at AstraZeneca within theNeuroscience Innovative Medicines Group. He has spent his career indrug discovery with a strong interest in developingphosphodiesterase inhibitors for neuropsychiatric disorders andunderstanding the basic mechanisms of phosphodiesterasefunction.
ANTHONY WEST is an Associate Professor in the Departmentof Neuroscience at Rosalind Franklin University. He has studied PDEfunction in the basal ganglia for over fifteen years, focusing onneurochemical and electrophysiological changes induced by PDEinhibitors in the healthy brain and in animal models ofParkinson's disease and Huntington's disease.