Camm / Malik / Yap Acquired Long QT Syndrome

1. Auflage 2008
ISBN: 978-1-4051-4616-6
Verlag: John Wiley & Sons
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 208 Seiten, E-Book

In recent years there has been considerable interest in thediagnosis and understanding of ventricular repolarisation,particularly the QT interval prolongation and abnormal T and T/Uwave morphology associated with torsades de pointes. Advances inion channel cloning have greatly improved our understanding of therole of ionic channels in mediating cardiac repolarisation.Unfortunately, it is increasingly recognised that a number ofdrugs, both those associated with altering repolarisation, andothers for non-cardiac conditions can increase the propensity forpolymorphic ventricular tachycardia, syncope and even ventricularfibrillation and sudden death.
In this volume, arrhythmia specialists from St. George'sHospital Medical School, London discuss the mechanisms behind QTprolongation and torsades de pointes. They focus particularly onthe risk of individual cardiac and non-cardiac drugs in provokinglong QT syndrome, providing a comprehensive review which will beuseful for all electrophysiologists treating polymorphicventricular tachycardias, and will expose important regulatoryissues for pharmaceutical authorities and for the wider medicalcommunity.

Autoren/Hrsg.

Camm, A. John

Malik, Marek

Yap, Yee Guan

Inhaltsverzeichnis

Preface vi
1 Introduction 1
2 Mechanisms of acquired QT prolongation and torsades de pointes 8
3 Measurement of the QT interval and repolarization assessment 24
4 Introduction to drug-induced long QT syndrome 60
5 Risk of QT prolongation and torsades de pointes with antiarrhythmic drugs 69
6 Risk of QT prolongation and torsades de pointes with antihistamines 87
7 Risk of QT prolongation and torsades de pointes with psychotropic drugs 102
8 Risk of QT prolongation and torsades de pointes with antimicrobial and antimalarial drugs 121
9 Risk of QT prolongation and torsades de pointes with prokinetics and miscellaneous other drugs 140
10 Acquired long QT syndrome secondary to cardiac conditions 163
11 Acquired long QT syndrome secondary to noncardiac conditions 171
12 Perspective on drug-induced repolarization changes 182
Index 191

Über Autor(innen)

A. John Camm, MD, FRCP, FESC, FACC
Professor of Clinical Cardiology and Head, Department ofCardiological Sciences, St. George's Hospital Medical School,London
Marek Malik, PhD, MD, DSc, FACC, FECS
Professor of Cardiac Electrophysiology, Department of CardiologicalSciences, St. George's Hospital Medical School, London
Yee Guan Yap, BMedSci, MBBS, MRCP
British Heart Foundation Research Fellow in Cardiology, Departmentof Cardiological Sciences, St. George's Hospital MedicalSchool, London