Chadwick / Goode Molecular Clocks and Light Signalling

1. Auflage 2004
ISBN: 978-0-470-09082-4
Verlag: John Wiley & Sons
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 306 Seiten, E-Book

Reihe: Novartis Foundation Symposia

The ability at the molecular level to keep track of time is aproperty shared by organisms ranging from the simplest unicells tohumans. The primary feature of these biological clocks is theirability to entrain to environmental stimuli. The dominant stimuluscomes from environmental light cues, which requires the existenceof photopigments sensitive to light. The exact identity of themolecules involved in circadian photoreception has remainedelusive.
The classical view of the circadian system is of diversephysiological rhythms regulated by a centralized clock structure.This book presents evidence that challenges this view. Experimentsin both vertebrate and invertebrate systems demonstrate that thecircadian timing system is dispersed throughout the animal andsuggest that possibly every cell contains an autonomous clockmechanism. A variety of tissues and cells contain have been shownto maintain an oscillation when placed in vitro and removed fromany external cues or signals that originate from the classicalclock structures and/or the environment.
This book draws together contributions from an international andinterdisciplinary group of experts whose work is focused on allaspects of the topic. Coverage includes the mechanisms of lightsignalling to the vertebrate clock, the connections between centraland peripheral clocks, circadian gene expression patterns andoutput pathways of clock mechanisms.

Autoren/Hrsg.

Chadwick, Derek J.

Goode, Jamie A.

Inhaltsverzeichnis

Chair's Introduction (M. Menaker).
Non-rod, non-cone photoreception in rodents and teleost fish (R.Foster, et al.).
Cryptochromes and inner retinal non-visual irradiance detection(R. Van Gelder and A. Sancar).
General discussion I.
Light signalling in Cryptochrome-deficient mice (X.Bonnefont, et al.).
Circadian light input in plants, flies and mammals (S. Panda, etal.).
Orphan nuclear receptors, molecular clockwork and theentrainment of peripheral oscillators (N. Preitner, et al.).
SCN: ringmaster of the circadian circus or conductor of thecircadian orchestra? (A. Davidson, et al.).
On the communication pathways between the central pacemaker andperipheral oscillators (N. Cermakian, et al.).
Central and peripheral circadian oscialltors inDrosophila (P. Hardin, et al.).
Integration of molecular rhythms in mammalian circadian system(H. Okamura).
Circadian transcriptional output in the SCN and liver of themouse (J. Hogenesch, et al.).
The molecular workings of the Neurospora biological clock(A. Froehlich, et al.).
Expression of the clock gene products in the suprachiasmaticnucleus in relation to circadian behaviour (M. Hastings, etal.).
Circadian rhythms in Drosophila (M. Rosbash, et al.).
The role of phosphorylation and degradation of hPer proteinsoscillation in normal human fibroblasts (K. Miyazaki, et al.).
Regulation of daily locomotor activity and sleep by hypothalamicEGF receptor signalling (A. Kramer, et al.).
CK1 and GSK-3 in the Drosophila and mammalian circadianclock (E. Harms, et al.).
Final general discussion.
Closing remarks (M. Menaker).
Index of Contributors.
Subject Index.