Chadwick / Goode Purinergic Signalling in Neuron-Glia Interactions

1. Auflage 2006
ISBN: 978-0-470-03223-7
Verlag: John Wiley & Sons
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 302 Seiten, E-Book

Reihe: Novartis Foundation Symposia

ATP, the intracellular energy source, is also an extremelyimportant cell-cell signalling molecule for a wide variety ofcells across evolutionarily diverse organisms. The extracellularbiochemistry of ATP and its derivatives is complex, and themultiple membrane receptors that it activates are linked to manyintracellular signalling systems.
Purinergic signalling affects a diverse range of cellularphenomena, including ion channel function, cytoskeletal dynamics,gene expression, secretion, cell proliferation, differentiation andcell death. Recently, this class of signalling molecules andreceptors has been found to mediate communication between neuronsand non-neuronal cells (glia) in the central and peripheral nervoussystems. Glia are critical for normal brain function, developmentand response to injury. Neural impulse activity is detected by gliaand purinergic signalling is emerging as a major means ofintegrating functional activity between neurons, glia and vascularcells in the nervous system. These interactions mediate effects ofneural activity on the development of the nervous system and inassociation with injury, neurodegeneration, myelination andcancer.
Bringing together contributions from experts in diverse fields,including glial biologists, neurobiologists and specialists inpurinergic receptor structure and pharmacology, this book considershow extracellular ATP acts to integrate communication betweendifferent types of glia, and between neurons and glia. Beginning with an overview of glia and purinergic signalling, itcontains detailed coverage of purine release, receptors andreagents, purinergic signalling in the neural control of glialdevelopment, glial involvement in information processing, anddiscussion of the interactions between neurons and microglia.

Autoren/Hrsg.

Chadwick, Derek J.

Goode, Jamie A.

Inhaltsverzeichnis

Symposium on Purinergic signalling in neuron-gliainteractions, held at the Novartis Foundation, London,7-9 June 2005.
Editors: Derek J. Chadwick (Organizer) and JamieGoode.
This symposium was based on a proposal made by R. DouglasFields.
R. Douglas Fields Chair's introduction.
Kristjan R. Jessen A brief look at glial cells.
Bernard Zalc The acquisition of myelin: a successstory.
Discussion.
Geoffrey Burnstock Purinergic signalling--anoverview.
Discussion.
General discussion I.
Kenneth A. Jacobson, Stefano Costanzi, Bhalchandra V.Joshi, Pedro Besada, Dae Hong Shin, Hyojin Ko, AndreiIvanov and Liaman Mamedova Agonists and antagonists forP2 receptors.
Discussion.
Eduardo Lazarowski Regulated release of nucleotides andUDP sugars from astrocytoma cells.
Discussion.
Maria P. Abbracchio and Claudia VerderioPathophysiological roles of P2 receptors in glial cells.
Discussion.
General discussion II.
Herbert Zimmermann ectonucleotidases in the nervoussystem.
Discussion.
Joseph T. Neary, Yuan Kang, You-fang Shi, Minh D. Tranand Ina B. Wanner P2 receptor signalling, proliferation ofastrocytes, and expression of molecules involved in cell-cellinteractions.
Discussion.
R. Douglas Fields nerve impulses regulate myelinationthrough purinergic signalling.
Discussion.
Beth Stevens Cross-talk between growth factor andpurinergic signalling regulates Schwann cell proliferation.
Discussion.
Freddy Jeanneteau and Moses V. Chao Promotingneurotrophic effects by GPCR ligands.
Discussion.
Eric A. Newman A purinergic dialogue between glia andneurons in the retina.
Discussion.
Tommaso Fellin, Jai-Yoon Sul, Marcello D'Ascenzo,Hajime Takano, Olivier Pascual and Philip G.Haydon Bidirectional astrocyte-neuron communication: themany roles of glutamate and ATP.
Discussion.
Keith J. Todd and Richard Robitailleneuron-glia interactions at the neuromuscular synapse.
Discussion.
General discussion III.
Stéphane H.R. Oliet, Aude Panatier and RichardPiet Functional neuronal-glial anatomical remodelling inthe hypothalamus.
Discussion.
Francesco Di Virgilio Purinergic signalling between axonsand microglia.
Discussion.
Kazuhide Inoue ATP receptors of microglia involved inpain.
Discussion.
Final discussion.
Index of contributors.
Subject index.

Über Autor(innen)

The Novartis Foundation is an international scientific and educational charity which promotes the study and general knowledge of science and in particular encourages international co-operation in scientific research.