Chakrabarty / Xu Digital Microfluidic Biochips

Design Automation and Optimization
Erscheinungsjahr 2011
ISBN: 978-1-4398-5873-8
Verlag: Taylor & Francis
Format: EPUB
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 213 Seiten

Microfluidics-based biochips combine electronics with biochemistry, providing access to new application areas in a wide variety of fields. Continued technological innovations are essential to assuring the future role of these chips in functional diversification in biotech, pharmaceuticals, and other industries.

Revolutionary guidance on design, optimization, and testing of low-cost, disposable biochips
Microfluidic Biochips: Design Automation and Optimization comprehensively covers the appropriate design tools and in-system automation methods that will help users adapt to new technology and progress in chip design and manufacturing. Based on results from several Duke University research projects on design automation for biochips, this book uses real-life bioassays as examples to lay out an automated design flow for creating microfluidic biochips. It also develops solutions to the unique problems associated with that process.

Highlights the design of the protein crystallization chip to illustrate the benefits of automated design flow
In addition to covering automated design, the authors provide a detailed methodology for the testing, use, and optimization of robust, cost-efficient, manufacturable digital microfluidic systems used in protein crystallization and other areas. The invaluable tools and practices presented here will help readers to:

- Address optimization problems related to layout, synthesis, droplet routing, and testing for digital microfluidic biochips

- Make routing-aware, architectural-level design choices and defect-tolerant physical design decisions simultaneously

- Achieve the optimization goal, which includes minimizing time-to-response, chip area, and test complexity

- Effectively deal with practical issues such as defects, fabrication cost, physical constraints, and application-driven design

The authors present specialized pin-constrained design techniques for making biochips with a focus on cost and disposability. They also discuss chip testing to ensure dependability, which is key to optimizing safety-critical applications such as point-of-care medical diagnostics, on-chip DNA analysis, automated drug discovery, air-quality monitoring, and food-safety testing. This book is an optimal reference for academic and industrial researchers in the areas of digital microfluidic biochips and electronic design automation.

Zielgruppe

Readers with a background in electronic design automation or circuit/system testing; graduate students in electrical engineering and biomedical engineering; academic and industrial researchers in microfluidic biochips and electronic design automation; engineers in the microfluidic biochip industry.

Autoren/Hrsg.

Chakrabarty, Krishnendu

Xu, Tao

Fachgebiete

• Technische Wissenschaften Elektronik | Nachrichtentechnik Elektronik Bauelemente, Schaltkreise
• Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Biotechnologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Medizintechnik, Biomedizintechnik, Medizinische Werkstoffe

Inhaltsverzeichnis

Introduction

Digital
Microfluidic Technology

Synthesis, Testing,
and Pin-Constrained Design Techniques

Protein
Crystallization

Book Outline

Defect-Tolerant and Routing-Aware Synthesis

Background

Routing-Aware Synthesis

Defect-Tolerant Synthesis

Simulations
Results

Chapter Summary
and Conclusions

Pin-Constrained Biochip Design

Droplet-Trace-Based Array-Partitioning

Cross-Referencing-Based Droplet Manipulation Method

Broadcast-Addressing Method

Chapter
Summary and Conclusion

Testing and Diagnosis

Parallel
Scan-like Test

Diagnosis of
Multiple Defects

Performance
Evaluation

Application
to Fabricated Biochips

Functional
Test

Simulation
Results

Chapter
Summary and Conclusions

Design for Testability

Testability
of a Digital Microfluidic Biochip

Testability-Aware Pin-constrained Chip Design

Simulation
Results

Chapter
Summary and Conclusions

Application on Protein Crystallization

Protein
Crystallization Chip Design

Automated
Solution Preparation

Chapter
Summary and Conclusions

Conclusions

Book
Contributions

New
Directions

References

Über Autor(innen)

Krishnendu Chakrabarty is a Professor of Electrical and Computer Engineering at Duke University and a Chair Professor of Software Theory at Tsinghua University, Beijing, China. Tao Xu is a DFT Engineer at Cisco Systems, Inc.