Molecular and Cellular Mechanobiology

Softcover Nachdruck of the original 1. Auflage 2016
ISBN: 978-1-4939-8166-3
Verlag: Springer

Buch, Englisch, 302 Seiten, Previously published in hardcover, Format (B × H): 155 mm x 235 mm, Gewicht: 4803 g

Reihe: Physiology in Health and Disease

This book will cover the cutting-edge developments in molecular and cellular mechanobiology to date. Readers will have a clear understanding of mechanobiology at the molecular and cellular levels, encompassing the mechanosensors, transducers, and transcription. An integrative approach across different scales from molecular sensing to mechanotransduction and gene modulation for physiological regulation of cellular functions will be explored, as well as applications to pathophysiological states in disease. A comprehensive understanding of the roles of physicochemical microenvironment and intracellular responses in determining cellular function in health and disease will also be discussed.

Zielgruppe

Research

Autoren/Hrsg.

Chien, Shu

Wang, Peter Yingxiao

Engler, Adam J.

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Molekulare Medizin, Zellbiologie
• Naturwissenschaften Biowissenschaften Zellbiologie
• Naturwissenschaften Physik Quantenphysik Atom- und Molekülphysik
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Physiologie
• Naturwissenschaften Biowissenschaften Molekularbiologie
• Naturwissenschaften Biowissenschaften Proteinforschung
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Biomedizin, Medizinische Forschung, Klinische Studien

Inhaltsverzeichnis

Part 1. Mechanosensors.- The Primary Cilium as a Strain Amplifying Microdomain for Mechanotransduction at the Cell Membrane.- Vascular Endothelial Mechanosensors in Response to Fluid Shear Stress.- Cadherins in Mechanotransduction.- Perspectives of FRET Imaging to study Epigenetics and Mechanobiology in the Nucleus.- Part 2. Transducers.- Emerging Roles of YAP/TAZ in Mechanobiology.- Role of Rho GTPases in Mechanobiology.- Illuminating Cell Adhesion: Modern Microscopy Approaches to Study Integrin-Based Focal Adhesions.- Part 3. Epigenetic and Genetic Regulations in the Nucleus.- Mechanotransduction to Epigenetic Remodeling.- The Nuclear Lamina: From Mechano-Sensing in Differentiation to Cancer Cell Migration.- Role of Cell Geometry on Nuclear Mechanics, Chromosome Reorganization, and Gene Expression.- Part 4. Applications.- Mechanobiological Control of Cell Fate for Applications in Cardiovascular Regenerative Medicine.- Heart Valve Mechanobiology in Development and Disease.- Molecular and Cellular Mechanobiology of Cancer.