Conrad / Chan / Fritzler | From Pathogenesis to Therapy of Autoimmune Diseases | Buch | 978-3-89967-579-5 | www.sack.de

Buch, Englisch, 568 Seiten, PB, Format (B × H): 148 mm x 210 mm, Gewicht: 960 g

Conrad / Chan / Fritzler

From Pathogenesis to Therapy of Autoimmune Diseases

Report on the 9th Dresden Symposium on Autoantibodies held in Dresden on September 2-5, 2009
Erscheinungsjahr 2009
ISBN: 978-3-89967-579-5
Verlag: Pabst Science Publishers

Report on the 9th Dresden Symposium on Autoantibodies held in Dresden on September 2-5, 2009

Buch, Englisch, 568 Seiten, PB, Format (B × H): 148 mm x 210 mm, Gewicht: 960 g

ISBN: 978-3-89967-579-5
Verlag: Pabst Science Publishers


In the spectrum of immunological diseases affecting various organs by inflammation and/or fibrosis, autoimmune reactions play an important role. Based on different studies both in humans as well as in animal models it becomes obvious that there is a broad range of pathologies that involve not only „primary“ autoimmune reactions but also other pathogenic mechanisms such as postinfectious and autoinflammatory processes. The heterogeneity within the immunological diseases may reflect the variable expression of autoinflammatory, autoimmune, and up to now unknown factors in disease development and manifestation. Based on histological and immunohistochemical examinations, IgG4-related sclerosing disease has been proposed as a novel clinicopathological entity with autoimmune phenomena but unknown etiology (chapter 1). The clarification of the etiopathological mechanisms is required to optimize prophylaxis, diagnostics and therapy. Especially, the application of novel and designer biological therapies (chapter 8) requires a better understanding of the processes that are involved in the genesis of immunological diseases. In chapter 2, some aspects of the role of epigenetic mechanisms and innate immunity in the pathogenesis of autoimmune diseases are described. Regardless of the underlying pathology, disease-associated autoantibodies are important biomarkers for the vast majority of non-organ and organ specific autoimmune diseases. However, to improve our understanding of these diseases and serological diagnostics it is necessary to search for novel autoantibodies, to further evaluate the real clinical relevance of known autoantibodies and to further develop and standardize the detection methods (chapters 3-5). Pathogenetic aspects as well as aspects of the serological diagnostics, including novel autoantibody specificities, novel methodologies and evaluation studies are presented for rheumatoid arthritis, systemic lupus erythematosus, antiphospholipid syndrome, systemic vasculitides, systemic sclerosis (chapter 6) and various organ specific diseases (chapter 7). In summary, the present volume highlights novel insights into the immune dysregulation, pathogenesis, serological diagnostics and biological therapies of autoimmune diseases.

Conrad / Chan / Fritzler From Pathogenesis to Therapy of Autoimmune Diseases jetzt bestellen!


Ihre Fragen, Wünsche oder Anmerkungen
Vorname*
Nachname*
Ihre E-Mail-Adresse*
Kundennr.
Ihre Nachricht*
Lediglich mit * gekennzeichnete Felder sind Pflichtfelder.
Wenn Sie die im Kontaktformular eingegebenen Daten durch Klick auf den nachfolgenden Button übersenden, erklären Sie sich damit einverstanden, dass wir Ihr Angaben für die Beantwortung Ihrer Anfrage verwenden. Selbstverständlich werden Ihre Daten vertraulich behandelt und nicht an Dritte weitergegeben. Sie können der Verwendung Ihrer Daten jederzeit widersprechen. Das Datenhandling bei Sack Fachmedien erklären wir Ihnen in unserer Datenschutzerklärung.