DNA Damage, DNA Repair and Disease

Two-volume Set
Erscheinungsjahr 2020
ISBN: 978-1-83916-252-7
Verlag: Royal Society of Chemistry

Buch, Englisch, 936 Seiten, Format (B × H): 156 mm x 234 mm, Gewicht: 1730 g

Reihe: Chemical Biology

The DNA of all organisms is constantly being damaged by endogenous and exogenous sources. Oxygen metabolism generates reactive species that can damage DNA, proteins and other organic compounds in living cells. Exogenous sources include ionizing and ultraviolet radiations, carcinogenic compounds and environmental toxins among others. The discovery of multiple DNA lesions and DNA repair mechanisms showed the involvement of DNA damage and DNA repair in the pathogenesis of many human diseases, most notably cancer. These books provide a comprehensive overview of the interdisciplinary area of DNA damage and DNA repair, and their relevance to disease pathology. Edited by recognised leaders in the field, this two-volume set is an appealing resource to a variety of readers including chemists, chemical biologists, geneticists, cancer researchers and drug discovery scientists.

Autoren/Hrsg.

Dizdaroglu, Miral

LLoyd, R Stephen

Weitere Mitwirkende

Weissman, Kira J

Fachgebiete

• Naturwissenschaften Biowissenschaften Biochemie (nichtmedizinisch)
• Naturwissenschaften Chemie Organische Chemie
• Naturwissenschaften Biowissenschaften Biowissenschaften DNA und Transgene Organismen

Inhaltsverzeichnis

Biomonitoring of DNA Damage in Humans; Tandem and Clustered Lesions from Radicals in Nucleic Acids from a Single Initial Chemical Event; Oxidative DNA Damage and Repair in G-Quadruplexes; Oxidatively Induced DNA Damage: Mechanisms and Measurement; Oxidation of the C5' Position in DNA and the Role of Purine 5',8-Cyclo-2'-deoxynucleoside Lesions; Ferroptosis and Oxidative DNA Damage; DNA-Protein Cross-Links: Formation, Genotoxicity and Repair; Substrate Specificities of DNA Glycosylases in vitro and in vivo; The Special Problems for Base Excision Repair in Coping with Oxidatively-induced DNA Damage; Genomic Uracil in Biology, Immunity and Cancer; Alternative DNA Repair Pathways to Handle Complex DNA Damage Generated by Oxidative Stress and Anticancer Drugs; Redox Stress Responses and Human Disease: NTHL1 at the Intersection of DNA Damage Repair and Cancer; Emerging Roles of Non-Canonical RNA Binding Proteins in Repair of Genome Damage Linked to Human Pathologies; Modulation of DNA Glycosylase Activities via Small Molecules; DNA Repair in the Development of Human Diseases and Therapy; Mechanisms and Maps of Nucleotide Excision Repair; Emerging Concepts on the Early Steps of Base Excision Repair Pathway with a Focus on Gene Expression; Base Excision Repair in Plants: Variations on a Theme; OGG1 at the Crossroads of Inflammation and DNA Base Excision Repair; Fidelity Mechanisms of DNA Polymerase Beta; DNA Damage Leads to Neurodegeneration via Mitochondrial Dysfunction; Emerging Roles of Sirtuins in Chromatin Regulation and DNA Repair Via their NAD+-dependent Activities; Unique Roles of Human Translesion Synthesis DNA Polymerase; Replicative and Transcriptional Bypass of Alkylated DNA Lesions in Human Cells; Mutational Spectra Provide Insight into the Mechanisms Bridging DNA Damage to Genetic Disease; Evolving DNA Repair Targets for Cancer Therapy; Basic, Translational and Clinical Relevance of the DNA Repair and Redox Signaling Protein APE1 in Human Diseases; The role of PARP and the therapeutic potential of PARP inhibitors in cancer; Translating DNA Adduct Knowledge to Human Prevention Trials; DNA Damage and the Maintenance of Nuclear Genome Integrity in Aging and Associated Phenotypes; Gamma- and Ion-beam DNA Radiation Damage: Theory and Experiment;