Protein Modificomics

From Modifications to Clinical Perspectives
Erscheinungsjahr 2019
ISBN: 978-0-12-811913-6
Verlag: Elsevier Science

Buch, Englisch, 387 Seiten, Format (B × H): 152 mm x 226 mm, Gewicht: 604 g

Protein Modificomics: From Modifications to Clinical Perspectives comprehensively deals with all of the most recent aspects of post-translational modification (PTM) of proteins, including discussions on diseases involving PTMs, such as Alzheimer's, Huntington's, X-linked spinal muscular atrophy-2, aneurysmal bone cyst, angelman syndrome and OFC10. The book also discusses the role PTMs play in plant physiology and the production of medicinally important primary and secondary metabolites. The understanding of PTMs in plants helps us enhance the production of these metabolites without greatly altering the genome, providing robust eukaryotic systems for the production and isolation of desired products without considerable downstream and isolation processes.

Autoren/Hrsg.

Dar, Tanveer Ali

Singh, Laishram Rajendrakumar

Fachgebiete

• Naturwissenschaften Biowissenschaften Mikrobiologie
• Naturwissenschaften Biowissenschaften Proteinforschung

Inhaltsverzeichnis

1. Emerging roles of posttranslational modifications in biological processes and their implications in associated diseases 2. Clinical perspective of posttranslational modifications 3. Phosphorylation and acetylation of proteins as posttranslational modification: implications in human health and associated diseases 4. Protein modifications and lifestyle disorders 5. Ubiquitin mediated posttranslational modification of proteins involved in various signaling diseases 6. Improving pharmacological efficacy of protein pharmaceuticals by glycosylation 7. Posttranslational modification in human therapeutics heterologously produced in plant host expression systems 8. Protein modification in plants in response to abiotic stress 9. Posttranslational modifications associated with cancer and their therapeutic implications 10. Nonenzymatic posttranslational protein modifications: mechanisms and associated disease pathologies 11. Protein covalent modification by homocysteine: consequences and clinical implications 12. Posttranslational modifications in algae: role in stress response and biopharmaceutical production 13. Protein glycosylation: an important tool in diagnosis or early detection of diseases

Über Autor(innen)

Dar, Tanveer Ali
Dr. Tanveer Ali Dar, affiliated with University of Kashmir, stands as a pioneer in the dynamic and evolving field of osmolyte-protein biology. Holding advanced degrees in his field, Dr. Dar has dedicated his career to advancing scientific knowledge and innovation in osmolyte research. Utilizing a multidisciplinary approach that combines biochemical, biophysical, and molecular biology techniques, Dr. Dar explores the dynamic interplay between osmolytes and proteins at the molecular level. His research sheds light on how osmolytes modulate protein structure and dynamics, enabling cells to adapt and thrive under stressful conditions such as osmotic stress, temperature fluctuations, and disease states. He has to his credit several breakthrough contributions in the area of exploring the osmolyte induced structural-functional integrity of proteins and their implications in protein misfolding disease interventions. Besides focusing on several aspects of osmolyte research, his research particularly emphasizes on understanding the roles of osmolytes and intrinsically disordered proteins in cellular function and disease pathogenesis. His pioneering investigations have shed light on the dynamic interplay between these molecular entities, unraveling fundamental mechanisms underlying cellular resilience and disease progression. Dr. Dar is recognized for his contributions to both theoretical understanding and practical applications in the osmolyte-field, and his work has been published in numerous peer-reviewed international journals. Moreover, he has to his credit a couple of books published by Springer International Ltd., Apple academic Press and Elsevier, USA. Dr. Dar is also a recipient of Indian National Science Academy visiting fellowship and is a member of various international and national scientific societies like ASBMB, Canadian Society of Molecular Biosciences, National Academy of Sciences India, India Biophysical society etc. He is a prolific reviewer, editor and editorial board member of a number of prestigious journals. As an educator, he is committed to nurturing the next generation of scientists, mentoring students and guiding them towards excellence in research.