das Neves / Das Neves / Sarmento Drug Delivery and Development of Anti-HIV Microbicides

1. Auflage 2014
ISBN: 978-981-4463-57-7
Verlag: Pan Stanford Publishing
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 706 Seiten

The worldwide impact of HIV/AIDS is well recognized. This book provides for the first time a thorough and critical overview of current aspects, recent developments, and trends in the formulation and drug delivery concerning anti-HIV microbicides by leading scientists in the field. Additionally, pertinent regulatory aspects and socioeconomical issues related to the subject are discussed. In the absence of a cure, prophylaxis represents a cornerstone in the battle against infection. One promising strategy comprises the use around the time of sexual intercourse of vaginal/rectal products containing antiviral compounds, termed microbicides. It is now recognized that specific development of drug dosage forms and/or drug delivery systems is an indispensable aspect for the success of microbicides. Different groups strived over the last decade to optimize the biophysical and technological performance of traditional dosage forms (gels, tablets, and suppositories) to fulfill the specificities of microbicides use, without neglecting users’ preferences and affordability issues. Moreover, new formulation approaches, such as vaginal rings and films, nanotechnology-based systems, stimuli-sensitive formulations, targeted drug delivery systems, among others have been proposed and are currently undergoing pre-clinical or even clinical testing.

Autoren/Hrsg.

das Neves, José

Das Neves, Jose

Sarmento, Bruno

Fachgebiete

• Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Biotechnologie Medizinische Biotechnologie

Inhaltsverzeichnis

Preface

Microbicides and the HIV Pandemic

HIV Transmission Models: Lessons Learned for Microbicide Formulation Design

Challenges in Microbicide Drug Delivery: Identifying Targets and Evolving Strategies

Safety Issues Related with Microbicide Formulations

Biophysics, Drug Transport Modeling and Performance of Microbicide Formulations

Dosage Forms for Microbicides Formulation: Advantages and Pitfalls

Microbicide Vaginal Rings

Vaginal Microbicide Films

Rectal Microbicide Development, Formulation and Delivery

Design of Stimuli-Sensitive Microbicide Formulations

Nanotechnology-Based Systems for Microbicide Development; Nanofibers for Microbicide Drug Delivery

Modified Microflora for Microbicide Drug Delivery

Scale-up, Affordability and Intellectual Property Issues Related with Microbicide Formulation Development

Regulatory Issues Pertaining Microbicide Products

Socioeconomic and Behavioral Factors Influencing Choice, Adherence and Success of Microbicide Formulations

Über Autor(innen)

José das Neves has a PhD in pharmaceutical sciences from the University of Porto, Portugal. He is a researcher at Instituto Superior de Ciências da Saúde-Norte, CESPU, Gandra, Portugal and Faculty of Pharmacy, University of Porto, Portugal. His current research interests include vaginal drug delivery and the development of nanotechnology-based solutions for the development of anti-HIV microbicides.

Bruno Sarmento has a PhD in pharmaceutical technology from the University of Porto, Portugal. He is an affiliated researcher at INEB – Instituto de Engenharia Biomédica, University of Porto, Portugal and assistant professor of pharmaceutical and biopharmaceutical technology at Instituto Superior de Ciências da Saúde-Norte, CESPU, Gandra, Portugal. His current research focuses on nanomedicines and their application in the pharmaceutical and biomedical fields.