Esteller Epigenetics in Biology and Medicine

Erscheinungsjahr 2008
ISBN: 978-1-4200-0707-7
Verlag: Taylor & Francis
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 312 Seiten

Anomalous epigenetic patterns touch many areas of study including biomedical, scientific, and industrial. With perspectives from international experts, this resource offers an all-inclusive overview of epigenetics, which bridge DNA information and function by regulating gene expression without modifying the DNA sequence itself.  Epigenetics, in its most basic form, means heredity is not the sole determining factor in disease development. Rather, environmental and dietary factors can trigger a gene to behave in an unintended way, while the gene itself remains unchanged. Epigenetics in Biology and Medicinediscusses cell biology and epigenetics’ role in human, animal, and plant diseases, including distortions in DNA methylation. The text also covers histone modifications, and epigenomics, as well as dietary and environmental impacts on epigenetic changes. Addresses These Important Questions: - How promising are HDACi drugs as anti-tumor agents?

- Will restoring normal levels of miRNAs change the course of devastating diseases?

- Is it possible to alter epigenetic mechanisms once they are triggered?

- Is it possible to correct the abnormalities in methylation patterns that impact auto-immunities?
Represents a Landmark Publication in this Cutting-Edge Field Dr. Manel Esteller, the editor of the volume, is a leading expert in molecular genetics of endometrial carcinoma. Under his editorial guidance, this publication goes beyond heredity to explain the crucial role of epigenetics in plants and physical and psychological diseases. This text is applicable to a wide range of researchers, including those invested in the applications of cell biology, those involved in disease research and deciding genetic patterns, and those coalitions concerned with the impact of epigenetics and possible cures. As a result, it has the potential to launch the development of a new class of pharmaceuticals that could have the potential to drastically change the medical landscape in the near future.

Zielgruppe

Academic and industry scientists in molecular biology, biochemistry, cell biology, cancer research, immunology, genetics, neurobiology, and pathology.

Autoren/Hrsg.

Esteller, Manel

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Humangenetik
• Naturwissenschaften Biowissenschaften Biowissenschaften Genetik und Genomik (nichtmedizinisch)
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Biomedizin, Medizinische Forschung, Klinische Studien

Inhaltsverzeichnis

An Introduction to Epigenetics, M. Esteller
Epigenetics and Cancer: DNA Methylation, S. Ropero and M. Esteller
Epigenetics and Cancer: Histone Modifications, M.F. Fraga and M. Esteller
Epigenetic Drugs: DNA Demethylating Agents, E. Atallah and G. Garcia-Manero
Epigenetic Drugs: Histone Deacetylase Inhibitors, M. Peart and R.W. Johnstone
Sirtuins in Biology and Disease, A. Vaquero and D. Reinberg
microRNAs in Cell Biology and Diseases, M. Fabbri, C. M. Croce, and G. A. Calin
Chromatin Modifications by Polycomb Complexes, M. Vidal
Epigenetics and its Genetic Syndromes, R.J. Gibbons
Epigenetics and Immunity, E. Ballestar and B. Richardson
Etiology of Major Psychosis: Why Do We Need Epigenetics?, G. Oh and A. Petronis
Epigenetics and Cardiovascular Disease, G. Lund and S. Zaina
Plant Epigenetics, M. Meijón, L. Valledor, J.L. Rodríguez,
R. Hasbún, E. Santamaría, I. Feito,
M.J. Cañal, M. Berdasco, M.F. Fraga,
and R. Rodríguez
Epigenetics, Environment, and Evolution, D.M. Ruden, P. Rasouli, and X. Lu
Epigenetics and Epigenomics, J.I. Martín-Subero and R. Siebert