Fagarasan / Cerutti Advances in Immunology

1. Auflage 2010
ISBN: 978-0-12-381301-5
Verlag: Elsevier Science & Techn.
Format: EPUB
Kopierschutz: 6 - ePub Watermark

E-Book, Englisch, Band Volume 107, 304 Seiten

Reihe: Advances in Immunology

Advances in Immunology, a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for future. - Contributions from leading authorities and industry experts - Informs and updates on all the latest developments in the field

Autoren/Hrsg.

Fagarasan, Sidonia

Cerutti, Andrea

Inhaltsverzeichnis

1;Front Cover;1
2;Advances in Immunology;4
3;Copyright Page;5
4;Contents;6
5;Contributors;10
6;Preface;14
7;Chapter 1: Functional Biology of the IL-22-IL-22R Pathway in Regulating Immunity and Inflammation at Barrier Surfaces;16
7.1;1. Introduction;17
7.2;2. The IL-22-IL-22R Pathway;19
7.3;3. Regulation of IL-22 Expression;25
7.4;4. Biological Functions of the IL-22-IL-22R Pathway;29
7.5;5. Concluding Remarks;36
7.6;Acknowledgments;37
7.7;References;37
8;Chapter 2: Innate Signaling Networks in Mucosal IgA Class Switching;46
8.1;1. Functions of Mucosal IgA;47
8.2;2. Mechanisms of Mucosal IgA Production;49
8.3;3. Mucosal IgA Pathways Involving T Cells;51
8.4;4. Mucosal IgA Pathways not Involving T Cells;58
8.5;5. Dendritic Cell and Macrophage Signals in Mucosal IgA Production;64
8.6;6. Epithelial Cell Signals in Mucosal IgA Production ;70
8.7;7. Conclusions;72
8.8;Acknowledgments;73
8.9;References;73
9;Chapter 3: Specificity of the Adaptive Immune Response to the Gut Microbiota;86
9.1;1. Introduction;87
9.2;2. The Gut Microbiota in the Year 2010;91
9.3;3. Determinates of the Intensity of Adaptive Immunity to the Gut Microbiota;94
9.4;4. Probiotics;102
9.5;5. T Cell Immunity to the Gut Microbiota;103
9.6;6. Specificity of the B Cell Response to the Gut Microbiota;109
9.7;7. The Future: Grasping the Mist;115
9.8;Acknowledgments;115
9.9;References;116
10;Chapter 4: Intestinal Dendritic Cells;124
10.1;1. Introduction;125
10.2;2. Dendritic Cell Distribution in the Gut;126
10.3;3. Gut DC Origins;129
10.4;4. Unique Properties of Mucosal DCs;130
10.5;5. DC Interaction with the Environmental Factors;135
10.6;6. DC Migration to MLN;137
10.7;7. DCs in Intestinal Diseases;139
10.8;8. Conclusions and Future Perspectives;145
10.9;Acknowledgments;145
10.10;References;146
11;Chapter 5: The Many Face-Lifts of CD4 T Helper Cells;154
11.1;1. Introduction;155
11.2;2. T Helper Subset Paradigm: Th1/Th2;155
11.3;3. Contradictions of the Th1/Th2 Paradigm: New Subsets Come to Help;157
11.4;4. Plasticity in the T Helper Subsets;159
11.5;5. Epigenetic Control of Th Lineage Plasticity;160
11.6;6. Concluding Remarks;161
11.7;Acknowledgments;162
11.8;References;162
12;Chapter 6: GALT: Organization and Dynamics Leading to IgA Synthesis;168
12.1;1. GALT Compartments;169
12.2;2. Peyer's Patches;170
12.3;3. Characteristics of PP GCs;175
12.4;4. Isolated Lymphoid Follicles;179
12.5;5. Lamina Propria;184
12.6;6. Role of IgA in Gut;188
12.7;7. Conclusions and Perspective;189
12.8;Acknowledgment;189
12.9;References;190
13;Chapter 7: Bronchus-Associated Lymphoid Tissue (BALT): Structure and Function;202
13.1;1. Introduction;203
13.2;2. Lymphoid Architecture of BALT;204
13.3;3. Development and Maintenance of BALT;210
13.4;4. Antigen Acquisition;214
13.5;5. B Cell Responses in BALT;216
13.6;6. T Cell Responses;219
13.7;7. Role of BALT in Resistance to Infectious Disease;221
13.8;8. Role of BALT in Pulmonary Responses to Allergens and Environmental Antigens;228
13.9;9. Role of BALT in Response to Particulates and Cigarette Smoke;232
13.10;10. Contribution of BALT to Autoimmunity and Pulmonary Fibrosis;238
13.11;11. Role of BALT in Pulmonary Malignancy;240
13.12;12. Summary and Perspectives;244
13.13;Acknowledgments;244
13.14;References;244
14;Chapter 8: Host-Bacterial Symbiosis in Health and Disease;258
14.1;1. Establishment of Bacterial Communities in the Gastrointestinal Tract;259
14.2;2. Development of the Immune System by Commensal Microbiota;266
14.3;3. ProInflammatory Responses of Bacterial-Host Gut Interactions;271
14.4;4. Commensals Contribute to Host-Microbial Homeostasis by Actively Suppressing Inflammatory Responses During Health and Disease ;278
14.5;References;282
15;Index;290
16;Contents of Recent Volumes;298
17;Color Plates;306