Friedlander / Mueckler Molecular Biology of Receptors and Transporters: Bacterial and Glucose Transporters

1. Auflage 1992
ISBN: 978-0-08-058674-8
Verlag: Elsevier Science & Techn.
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, Band Volume 137A, 376 Seiten, Web PDF

Reihe: International Review of Cell and Molecular Biology

This multi-volume set within International Review of Cytology encompasses the recent advances in the understanding of structure-function relationships at the molecular level of receptors, transporters, and membrane proteins. Several diverse families of membrane receptors/proteins are discussed with respect to the molecular and cellular biology of their synthesis, assembly, turnover, and function. Included are such receptor superfamilies as G-proteins, immunoglobulins, ligand-gated receptors, interleukins, and tyrosine kinases as well as such transporter/protein families as pumps, ion channels, and bacterial transporters. Each section of each volume also features a 'perspectives/commentary' chapter which includes comments on the recent advances and predictions on new directions. Volume 137A highlights the recent advances in bacterial and glucose transporter mechanisms.

Autoren/Hrsg.

Friedlander, M.

Mueckler, Michael

Inhaltsverzeichnis

1;Cover;1
2;Molecular Biology of Receptors and Transporters;4
3;Copyright Page;5
4;Contents;6
5;Contributors;10
6;Forward;12
7;Preface;14
8;Chapter 1. Bacterial Periplasmic Permeases as Model Systems for the Superfamily of Traffic ATPases Including the Multidrug Resistance Protein and the Cystic Fibrosis Transmembrane Conductance Regulator;16
8.1;I. Introduction ;16
8.2;II. Periplasmic Permeases ;18
8.3;III. Relevance to Eukaryotic Carriers ;37
8.4;IV. Structure–Function Analysis of Eukaryotic Transporters;45
8.5;V. Future Prospects ;46
8.6;References ;47
9;Chapter 2. Amino Acid Transport in Bacteria;52
9.1;I. Introduction and Scope ;52
9.2;II. LIV-I: The High-Affinity Branched Chain Amino Acid Transport System of Escherichia coli ;53
9.3;III. Biochemistry and Mechanism of Amino Acid Transport ;60
9.4;lV. Physiology and Regulation of Amino Acid Transport in Bacteria;80
9.5;References ;105
10;Chapter 3. In and Out and Up and Down with Lac Permease;112
10.1;I. Permease Structure ;113
10.2;II. Membrane Insertion and Stability of Lac Permease ;116
10.3;III. Oligomeric State of Lac Permease ;117
10.4;IV. In Vivo Expression of the Lac Y Gene in Two Fragments Leads to Functional Lactose Permease ;119
10.5;V. Functional Complementation of Deletion Mutants ;121
10.6;VI. Insertional Mutagenesis ;123
10.7;VII. Use of Site-Directed Mutagenesis to Probe the Mechanism of Active Transport ;125
10.8;VIII. Summary and Concluding Remarks ;136
10.9;References ;137
11;Chapter 4. Group Translocation of Glucose and Other Carbohydrates by the Bacterial Phosphotransferase System;142
11.1;I. Introduction to and Scope of This Article ;142
11.2;II. The Bacterial Sugar Phosphotransferase System ;143
11.3;III. Structure and Function of the PTS Transporters ;149
11.4;IV. Perspectives ;159
11.5;References ;159
12;Chapter 5. Sugar–Cation Symport Systems in Bacteria;164
12.1;I. Introduction ;164
12.2;II. The Number of Proton-Linked Sugar Transport Systems in Bacteria ;166
12.3;III. Sugar Transport Systems in Eukaryotes ;172
12.4;IV. Inhibitors of Proton-Linked Sugar Transport ;177
12.5;V. The Locations of Genes Encoding Sugar–H+ Transport Proteins on the Chromosome of Escherichia coli;183
12.6;VI. The Primary Sequences of Sugar–H+ Transport Proteins Determined from DNA Sequences of the Genes;186
12.7;VII. Features of the Aligned Primary Sequences of the Homologous Sugar Transport Proteins ;194
12.8;VIII. Similarities between Sugar, Carboxylate, and Antibiotic Transport Proteins;203
12.9;IX. Structural Models of the Transport Proteins ;205
12.10;X. Identification of the Transport Proteins ;206
12.11;XI. Reconstitution ;209
12.12;XII. Conclusions ;210
12.13;References ;215
13;Chapter 6. Molecular and Cellular Physiology of GLUT-2, a High-Km Facilitated Diffusion Glucose Transporter;224
13.1;I. Introduction ;224
13.2;II. Structural and Functional Characterization of GLUT-2 ;225
13.3;III. Tissue and Cellular Localization of GLUT-2 ;231
13.4;IV. Conclusion ;249
13.5;References ;250
14;Chapter 7. The Insulin-Sensitive Glucose Transporter;254
14.1;I. Introduction ;254
14.2;II. The Translocation Hypothesis ;255
14.3;III. Intracellular Trafficking of the "Insulin-Sensitive" Glucose Transporter;276
14.4;IV. Glucose Transport in Muscle ;284
14.5;V. Long-Term Regulation of Insulin Responsiveness ;290
14.6;VI. Regulators of Insulin-Responsive Glucose Transport ;297
14.7;References ;302
15;Chapter 8. Molecular Genetics of Yeast Ion Transport;314
15.1;I. Introduction ;314
15.2;II. Plasma Membrane Ion Transport ;315
15.3;III. Vacuolar Ion Transport ;356
15.4;IV. Other Organelles ;359
15.5;V. Concluding Remarks ;362
15.6;References ;364
16;Index;370