Protein Misfolding in Neurodegenerative Diseases

Erscheinungsjahr 2025
ISBN: 978-0-443-18716-2
Verlag: Elsevier Science

Buch, Englisch, 574 Seiten, Format (B × H): 152 mm x 228 mm, Gewicht: 857 g

Protein Misfolding in Neurodegenerative Diseases is a comprehensive review of proteome homeostasis in neurons, and in the brain. Beginning with an introduction on factors involved in the formation and aggregation of misfolded proteins, chapters then discuss the precise cellular and molecular mechanisms involved in these processes and their role in neurodegeneration and disease. Additional topics of focus include protein clearance mechanisms like protein quality control, disease-modifiers, molecular druggable targets, novel therapeutics, and emerging techniques that block or delay disease onset or progression. This volume is relevant for researchers working with neurodegenerative diseases, including Alzheimer's disease, Parkinson’s disease, ALS, Creutzfeldt-Jakob disease, and more.

Autoren/Hrsg.

Gogia, Neha

Singh, Sandeep Kumar

Devarunda Jaganath, Vidyadhara

Fachgebiete

• Naturwissenschaften Biowissenschaften Biowissenschaften Genetik und Genomik (nichtmedizinisch)
• Interdisziplinäres Wissenschaften Wissenschaften Interdisziplinär Neurowissenschaften, Kognitionswissenschaft
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pathologie, Cytopathologie, Histopathologie
• Naturwissenschaften Biowissenschaften Molekularbiologie

Inhaltsverzeichnis

1. Maintenance of balanced proteome homeostasis 2. Determinants of protein misfolding, aggregation in neuronal cell death 3. Classification, structure, and function of protein aggregates in proteinopathies 4. Protein aggregation and cellular and molecular mechanisms in neurodegenerative disease 5. Advances in methods to detect and study protein aggregation 6. Organelle specific protein quality control 7. Molecular chaperones and co-chaperones in proteostasis 8. The ubiquitin-Proteasome System (UPS) and Autophagy lysosomal proteolytic pathways 9. Alterations in protein quality control 10. Alternate mechanisms to maintain proteome homeostasis 11. Advances in developing novel therapeutics, strategies, approaches and use of emerging techniques 12. Challenges in translating laboratory findings to drug development 13. Advancements in drug delivery technologies for protein misfolding diseases

Über Autor(innen)

Singh, Sandeep Kumar
Dr. Sandeep Kumar Singh is Assistant Professor in the All India Institute of Medical Sciences (AIIMS), Nagpur, India. He obtained his PhD in Biotechnology from Banaras Hindu University and conducted postdoctoral research in the Department of Neurobiology at the University of Chicago. Dr. Singh brings 17 years of experience in neuroscience, molecular biology, neurodegenerative diseases, aging, nutraceuticals, and nanomedicines. He is a member of several scientific societies, including the American Academy of Neurology, International Society of Neurochemistry, Society of Neurochemistry, Indian Academy of Neurosciences, and Alzheimer’s and related Disorders Society of India. Dr. Singh has published five books, including Elsevier’s A New Era in Alzheimer’s Research and Genome Editing for Neurodegenerative Diseases.

Devarunda Jaganath, Vidyadhara
Vidyadhara Devarunda Jaganath works in the Department of Neurology and Neuroscience, Yale University School of Medicine, CT, USA.

Gogia, Neha
Dr. Gogia is a Post-Doctoral Associate at Yale. Having completed her PhD degree at the University of Dayton, and Cornell University’s International Agriculture and Rural Development Program (IARD) she was awarded the Gerald L. Willis Award of Excellence for Outstanding Teaching in 2019. Her current work focuses on understanding cellular and molecular mechanisms underlying polyglutamine diseases, namely the identification and validation of genetic modifiers which can serve as potential therapeutic targets and can ameliorate the onset or progression of neurodegenerative diseases.