Greenberg Radical and Radical Ion Reactivity in Nucleic Acid Chemistry

1. Auflage 2009
ISBN: 978-0-470-52626-2
Verlag: John Wiley & Sons
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, Band 2, 472 Seiten, E-Book

Reihe: Wiley Series of Reactive Intermediates

Comprehensive coverage of radical reactive intermediates in nucleicacid chemistry and biochemistry
The Wiley Series on Reactive Intermediates in Chemistry andBiology investigates reactive intermediates from the broadestpossible range of disciplines. The contributions in each volumeoffer readers fresh insights into the latest findings, emergingapplications, and ongoing research in the field from a diverseperspective.
The chemistry and biochemistry of reactive intermediates iscentral to organic chemistry and biochemistry, and underlies asignificant portion of modern synthetic chemistry. Radical andRadical Ion Reactivity in Nucleic Acid Chemistry provides theonly comprehensive review of the chemistry and biochemistry ofnucleic acid radical intermediates.
With contributions by world leaders in the field, the textcovers a broad range of topics, including:
* A discussion of the relevant theory
* Ionization of DNA
* Nucleic acid sugar radicals
* Halopyrimidines
* Oxidative, reductive, and low energy electron transfer
* Electron affinity sensitizers
* Photochemical generative of reactive oxygen species
* Reactive nitrogen species
* Enediyne rearrangements
* Phenoxyl radicals
A unique compilation on the cutting edge of our understanding,Radical and Radical Ion Reactivity in Nucleic Acid Chemistryprovides an unparalleled resource to student and professionalresearchers in such fields as organic chemistry, biochemistry,molecular biology, and physical chemistry, as well as theindustries associated with these disciplines.

Autoren/Hrsg.

Greenberg, Michael D.

Inhaltsverzeichnis

Preface to Series vii
Introduction ix
Contributors xi
1. Theoretical Modeling of Radiation-Induced DNA Damage 1
Anil Kumar and Michael D. Sevilla
2. Radical Reaction Pathways Initiated by Direct EnergyDeposition in DNA by Ionizing Radiation 41
William A. Bernhard
3. Chemical Reactions of the Radical Cations of Nucleobases inIsolated and Cellular DNA. Formation of Single-Base Lesions69
Jean Cadet, Thierry Douki, Didier Gasparutto, Jean-Luc Ravanat,and J. Richard Wagner
4. Reactivity of Nucleic Acid Sugar Radicals 99
Chryssostomos Chatgilialoglu
5. Pyrimidine Nucleobase Radical Reactivity 135
Marc M. Greenberg
6. Reactivity of 5-Halopyrimidines in Nucleic Acids 163
Ryu Tashiro and Hiroshi Sugiyama
7. Kinetics of Long-Range Oxidative Electron Transfer ThroughDNA 191
Kiyohiko Kawai and Tetsuro Majima
8. Radical Intermediates During Reductive Electron TransferThrough DNA 211
Reji Varghese and Hans-Achim Wagenknecht
9. Low-Energy Electron Interaction with DNA: Bond Dissociationand Formation of Transient Anions, Radicals, and Radical Anions239
Leon Sanche
10. Electronic-Affinic Radiosensitizers 295
Peter Wardman
11. Reactions of Reactive Nitrogen Species and Carbonate RadicalAnions with DNA 325
Vladimir Shafirovich, Conor Crean, and Nicholas E.Geacintov
12. Principles and Applications of Electrochemical Oxidation ofNucleic Acids 357
H. Holden Thorp and Julie M. Sullivan
13. DNA Damage Due to Diradical-Generating Cyclizations389
Sean M. Kerwin
14. DNA Damage by Phenoxyl Radicals 421
Richard A. Manderville
Index 445

Über Autor(innen)

Marc M. Greenberg is a Professor of Chemistry and Directorof the Chemistry Biology Interface Graduate Training Program atJohns Hopkins University. His research uses chemistry,biochemistry, and biology to fundamentally understand how DNA isoxidatively damaged, and what the effects of that damage are.
Steven E. Rokita, PhD, is Professor in the Department ofChemistry and Biochemistry at the University of Maryland. Hisresearch interests lie in sequence and conformation specificreactions of nucleic acids, enzyme-mediated activation ofsubstrates and coenzymes, halogenation and dehalogenation reactionsin biology, aromatic substitution and quinone methide generation inbioorganic chemistry, and copper- and nickel-mediated reactions inbioinorganic chemistry.