Haeney Introduction to Clinical Immunology

1. Auflage 2014
ISBN: 978-1-4831-8264-3
Verlag: Elsevier Science & Techn.
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 140 Seiten, Web PDF

Introduction to Clinical Immunology provides an introduction to clinical immunology, which is described as the application of immunological principles to achieve a better understanding of the mechanisms of human diseases and appropriate laboratory investigations. This book discusses immunoglobulins, monoclonal immunoglobulins, IgE and atopic disease, and immune complexes. The antibody deficiency, defects of cell-mediated immunity, disorders of neutrophil function, and overview of autoimmune disease are also covered. This publication is recommended for junior doctors in training, but is also valuable to senior clinical investigators in all disciplines who find themselves reluctantly obliged to acquire the rudiments of immunology in order to interpret important developments in their own fields.

Autoren/Hrsg.

Haeney, Mansel

Inhaltsverzeichnis

1;Front Cover;1
2;Introduction to Clinical Immunology;4
3;Copyright Page;5
4;Table of Contents;8
5;Dedication;3
6;Preface;6
7;Acknowledgements;7
8;Chapter 1. Immunoglobulins and disease;10
8.1;Basic immunoglobulin structure;10
8.2;Immunoglobulin classes;10
8.3;Immunoglobulin structure versus function;11
8.4;Primary and secondary antibody responses;12
8.5;Immune response genes;13
8.6;Immunoglobulin levels and age;13
8.7;Abnormalities of immunoglobulins;14
8.8;Further reading;17
9;Chapter 2. Monoclonal immunoglobulins;18
9.1;Clinical significance of monoclonal proteins;18
9.2;Benign monoclonal gammopathy;23
9.3;IgM paraproteins;24
9.4;Waldenström's macroglobulinaemia;24
9.5;Malignant lymphoma;25
9.6;Paraproteins with antibody activity;25
9.7;Cryoglobulinaemia;26
9.8;Heavy chain diseases;27
9.9;Reference;27
9.10;Further reading;27
10;Chapter 3. IgE and atopic disease;28
10.1;Discovery of IgE;29
10.2;IgE molecule;29
10.3;Biological role of IgE;32
10.4;Regulation of IgE antibody synthesis;33
10.5;Pathogenesis of the atopic trait;36
10.6;Diagnostic tools in the investigation of allergic disease;37
10.7;Therapeutic approaches in the management of allergic disease;41
10.8;Further reading;43
10.9;Reference;43
11;Chapter 4. Complement and disease;44
11.1;Definition of complement;44
11.2;Terminology;44
11.3;Principles of complement activation;44
11.4;Complement activation pathways;45
11.5;Biological effects of complement;48
11.6;Laboratory assessment of complement activity;49
11.7;Clinical interpretation of changes in complement;50
11.8;Inherited defects in complement;52
11.9;Conclusion;56
11.10;Further reading;56
12;Chapter 5. Immune complexes and disease;57
12.1;Principles of the antigen–antibody reaction;57
12.2;Biological effects of immune complexes;57
12.3;Fate of immune complexes;60
12.4;Pathological effects of immune complex deposition;65
12.5;Clinical detection of immune complexes;66
12.6;Approach to the treatment of immune complex diseases;70
12.7;Clinical implications of the detection of immune complexes;72
12.8;Further reading;72
13;Chapter 6. Antibody deficiency;73
13.1;Cellular basis of defective immunity;73
13.2;Basic classification of immunodeficiency;75
13.3;Primary antibody deficiency;76
13.4;Causes of primary antibody deficiency (Table 6.1);80
13.5;Complications of antibody deficiency;85
13.6;Secondary causes of immunoglobulin deficiency;88
13.7;Treatment of antibody deficiency states;90
13.8;Further reading;92
14;Chapter 7. Defects of cell-mediated immunity;93
14.1;The assessment of cell-mediated immunity;93
14.2;Selective defects of cell-mediated immunity;96
14.3;Combined immunodeficiency;98
14.4;Secondary causes of impaired cell-mediated immunity;101
14.5;Therapeutic approaches to the treatment of impaired cell-mediated immunity;102
14.6;Conclusion;107
14.7;Further reading;107
15;Chapter 8. Disorders of neutrophil function;108
15.1;Introduction;108
15.2;Normal neutrophil function (Figure 8.1);108
15.3;Disordered neutrophil function;111
15.4;Therapeutic considerations;116
15.5;Conclusion;117
15.6;Further reading;117
16;Chapter 9. An overview of autoimmune disease;118
16.1;Introduction;118
16.2;Physiological role of self-recognition;118
16.3;Induction of self-tolerance;120
16.4;Failure of immunological control mechanisms;121
16.5;Mechanisms of autoimmune tissue damage;127
16.6;Approaches to the management of autoimmune disorders;131
16.7;Further reading;134
17;Index;136