Protein Interactions

The Molecular Basis of Interactomics
1. Auflage 2022
ISBN: 978-3-527-34864-0
Verlag: Wiley-VCH GmbH

Buch, Englisch, 432 Seiten, Format (B × H): 173 mm x 248 mm, Gewicht: 1021 g

Protein Interactions

A fundamental guide to the burgeoning field of protein interactions

From enzymes to transcription factors to cell membrane receptors, proteins are at the heart of biological cell function. Virtually all cellular processes are governed by their interactions, with one another, with cell bodies, with DNA, or with small molecules. The systematic study of these interactions is called Interactomics, and research within this new field promises to shape the future of molecular cell biology.

Protein Interactions goes beyond any existing guide to protein interactions, presenting the first truly comprehensive overview of the field. Edited by two leading scholars in the field of protein bioinformatics, this book covers all known categories of protein interaction, stable as well as transient, as well as the effect of mutations and post-translational modifications on the interaction behavior.

Protein Interactions readers will also find: - Introductory chapters on protein structure, conformational dynamics, and protein-protein binding interfaces
- A data-driven approach incorporating machine learning and integrating experimental data into computational models
- An outlook on the current challenges in the field and suggestions for future research

Protein Interactions will serve as a fundamental resource for novice researchers who want a systematic introduction to interactomics, as well as for experienced cell biologists and bioinformaticians who want to gain an edge in this exciting new field.

Autoren/Hrsg.

Helms, Volkhard

Kalinina, Olga V.

Fachgebiete

• Naturwissenschaften Biowissenschaften Molekularbiologie
• Naturwissenschaften Biowissenschaften Angewandte Biologie Bioinformatik
• Naturwissenschaften Biowissenschaften Zellbiologie
• Naturwissenschaften Chemie Organische Chemie Biochemie

Inhaltsverzeichnis

Protein Structure and Conformational Dynamics
Protein-Protein Binding Interfaces
Correlated Co-evolving Mutations at Protein-Protein Interfaces
Protein-Protein-Docking
Identification of Putative Protein Complexes in Protein-Protein Interaction Networks
Structures, Composition, and Modelling of Protein Complexes
Live-Cell Structural Biology to Solve Molecular Mechanisms: Structural Dynamics in the Exocyst Function
Kinetics and Thermodynamics of Protein-Protein Encounter
Markov-State Models for Protein-Protein Encounter
Transcription Factor-DNA Complexes
Chromatin Interactomics
Interactions of Proteins with mRNA and ncRNA
Interactions Between Proteins and Biological Membranes
Interactions of Proteins with Small Molecules
Effects of Mutations in Proteins on Their Interactions
Not Quite the Same: How Alternative Splicing Affects Protein Interactions
Phosphorylation-based Molecular Switches
Summary and Outlook

Über Autor(innen)

Volkhard Helms has been a full professor for bioinformatics at Saarland University since 2003. He received a Ph.D. for research done at EMBL Heidelberg, did post-doctoral work at UC San Diego, and subsequently was an independent group leader at the Max Planck Institute of Biophysics in Frankfurt. Professor Helms has authored about 200 scientific publications. In 2000, he was named an EMBO Young Investigator.
 
Olga Kalinina is a professor for drug bioinformatics at the Helmholtz Institute for Pharmaceutical Research Saarland since 2019. She received a Ph.D. from the Engelhardt Institute for Molecular Biology of the Russian Academy of Sciences in 2007, did post-doctoral work at EMBL Heidelberg and University of Heidelberg (2007-2011) and subsequently was a group leader at the MPI for informatics in Saarbrücken (2012-2018). Prof. Kalinina has authored over 40 scientific publications.