Humphery-Smith / Hecker Microbial Proteomics

Functional Biology of Whole Organisms
1. Auflage 2006
ISBN: 978-0-471-97315-7
Verlag: John Wiley & Sons
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, Band 48, 530 Seiten, E-Book

Reihe: Methods of Biochemical Analysis

Discover important lessons learned about whole organism biologyvia microbial proteomics
This text provides an exhaustive analysis and presentation ofcurrent research in the field of microbial proteomics, with anemphasis on new developments and applications and future directionsin research. The editors and authors show how and why the relativesimplicity of microbes has made them attractive targets forextensive experimental manipulation in a quest for both improveddisease prevention and treatment and an improved understanding ofwhole organism functional biology. In particular, the textdemonstrates how microbial proteomic analyses can aid in drugdiscovery, including identification of new targets, noveldiagnostic markers, and lead optimization.
Each chapter is written by one or more leading experts in thefield and carefully edited to ensure a consistent and thoroughapproach throughout. Methods, technologies, and tools associatedwith the most promising approaches are stressed. Key topics coveredinclude:
* Microbial pathogenesis at the proteome level
* Whole cell modeling
* Structural proteomics and computational analysis
* Biomolecular interactions
* Physiological proteomics
* Metabolic reconstruction using proteomics data
While presenting the practical utility of proteomics data, thetext is also clear on the field's current limitations, pointing toareas where further investigation is needed.
Offering a state-of-the-art perspective from internationallyrecognized experts, this text is ideally suited for researchers andstudents across the gamut of genomic sciences, includingbiochemistry, microbiology, molecular biology, genetics, biomedicaland pharmaceutical sciences, biotechnology, and veterinaryscience.

Autoren/Hrsg.

Humphery-Smith, Ian

Hecker, Michael

Inhaltsverzeichnis

PREFACE.
ACKNOWLEDGMENTS.
CONTRIBUTORS.
PART I: GENERAL PROTEOMICS OF MICROORGANISMS/MODELORGANISMS.
1. Holistic Biology of Microorganisms: Genomics,Transcriptomics, and Proteomics (Valerie Wasinger).
2. Strategies for Measuring Dynamics: The Temporal Component ofProteomics (Robert J. Beynon and Julie M. Pratt).
3. Quest for Complete Proteome Coverage (C. DavidO'Connor, Ian N. Clarke, and Paul Skipp).
4. Proteome of Mycoplasma pneumoniae (Richard Herrmann andThomas Ruppert).
5. Proteomics of Archaea (Ricardo Cavicchioli, AmberGoodchild, and Mark Raftery).
PART II: PROTEOMICS AND CELL PHYSIOLOGY.
6. Elucidation of Mechanisms of Acid Stress in Listeriamonocytogenes by Proteomic Analysis (Luu Phan-Thanh and LotharJänsch).
7. Oxidation of Bacterial Proteome in Response to Starvation(Thomas Nyström).
8. Tale of Two Metal Reducers: Comparative Proteome Analysis ofGeobacter sulferreducens PCA and Shewanella oneidensis MR-1(Carol S. Giometti).
9. AMT Tag Approach to Proteomic Characterization of Deinococcusradiodurans and Shewanella oneidensis (Mary S. Lipton, MargaretF. Romine, Matthew E. Monroe, Dwayne A. Elias, Ljiljana Pasa-Tolic,Gordon A. Anderson, David J. Anderson, Jim Fredrickson, Kim K.Hixson, Christophe Masselon, Heather Mottaz, Nikola Tolic, andRichard D. Smith).
PART III: PHYSIOLOGICAL PROTEOMICS OF INDUSTRIALBACTERIA.
10. Proteomics of Corynebacterium glutamicum: EssentialIndustrial Bacterium (Andreas Burkovski).
11. Proteomics of Lactococcus lactis: Phenotypes for a DomesticBacterium (Mogens Kilstrup).
12. Proteomic Survey through Secretome of Bacillus subtilis(Haike Antelmann, Jan Maarten van Dijl, Sierd Bron, and MichaelHecker).
PART IV: PROTEOMICS OF PATHOGENIC MICROORGANISMS.
13. Analyzing Bacterial Pathogenesis at Level of Proteome(Phillip Cash).
14. Unraveling Edwardsiella tarda Pathogenesis Using theProteomics Approach (P. S. Srinivasa Rao, Yuen Peng Tan, JunZheng, and Ka Yin Leung).
15. Structural Proteomics and Computational Analysis of a DeadlyPathogen: Combating Mycobacterium tuberculosis from Multiple Fronts(Michael Strong and Celia W. Goulding).
16. Proteomic Studies of Plant-Pathogenic Oomycetes and Fungi(Catherine R. Bruce, Pieter van West, and Laura J.Grenville-Briggs).
17. Candida albicans Biology and Pathogenicity: Insights fromProteomics (Aida Pitarch, Ce´sar Nombela, and ConchaGil).
18. Contributions of Proteomics to Diagnosis, Treatment, andPrevention of Candidiasis (Aida Pitarch, Ce´sar Nombela,and Concha Gil).
19. Identification of Protein Candidates for DevelopingBacterial Ghost Vaccines against Brucella (Vito G. Delvecchio,Tim Alefantis, Rodolfo A. Ugalde, Diego Comerci, Maria InesMarchesini, Akbar Khan, Werner Lubitz, and Cesar V. Mujer).
20. Genomics and Proteomics in Reverse Vaccines (GuidoGrandi).
PART V: PROTEOME DATABASES, BIOINFORMATICS, AND BIOCHEMICALMODELING.
21. Databases and Resources for in silico Proteome Analysis(Manuela Pruess, Paul Kersey, Tamara Kulikova, and RolfApweiler).
22. Interspecies and Intraspecies Comparison of MicrobialProteins: Learning about Gene Ancestry, Protein Function, andSpecies Life Style (Bernard Labedan and OlivierLespinet).
23. Cellular Kinetic Modeling of the Microbial Metabolism(Igor I. Goryanin, Galina V. Lebedeva, Ekaterina A.Mogilevskaya, Eugeniy A. Metelkin, and Oleg V. Demin).
INDEX.

Über Autor(innen)

IAN HUMPHERY-SMITH, PHD, is the Founding Chair of theDepartment of Pharmaceutical Proteomics at Utrecht University. Dr.Humphery-Smith has served as director of the Centre for ProteomeResearch and Gene-Product Mapping and served as managing directorand chief scientific officer of Glaucus Proteomics BV.
MICHAEL HECKER, PHD, is Professor of Microbiology andHead of the Institute for Microbiology atErnst-Moritz-Arndt-University of Greifswald in Germany. Dr. Heckeris currently Vice Chair of the International Union ofMicrobiological Societies (IUMS).