Invertebrate and Vertebrate Eye Development

1. Auflage 2010
ISBN: 978-0-12-385045-4
Verlag: Elsevier Science & Techn.
Format: EPUB
Kopierschutz: 6 - ePub Watermark

E-Book, Englisch, Band Volume 93, 312 Seiten

Reihe: Current Topics in Developmental Biology

Vision is our primary sensory modality, and we are naturally curious as to how the visual system assembles. The visual system is in many ways remarkably simple, a repeating assemblage of neurons and support cells that parse the visual field through precision and redundancy. Through this simplicity the eye has often led the way in our exploration of how an organ is assembled. Eye development has therefore long been a favorite for exploring mechanisms of cell fate choice, patterning and cell signaling.This volume, which is part of the Current Topics in Developmental Biology series, highlights the exceptional advances over the past 20 years. Chapters emphasize our knowledge of transcription factors and how these generate networks to direct the eye field and associated structures. Topics such as cell fate specification are also explored, along with the potential of Drosophila as a model for lens formation and the progress made in using the Drosophila eye to examine planar cell polarity. - Contributions from researchers who are active in identifying new paradigms to explore - Review of our current state of knowledge - Chapters written by authors with a new generation approach that takes a more systems approach to identifying factors and better defines cell subtypes

Autoren/Hrsg.

Inhaltsverzeichnis

1;Front Cover;1
2;Current Topics in Developmental Biology: Invertebrate and Vertebrate Eye Development;4
3;Copyright Page;5
4;Contents;6
5;Contributors;10
6;Preface;12
7;Chapter 1: Retinal Determination;14
7.1;1. Introduction;15
7.2;2. Structure and Development of the Drosophila Eye;15
7.3;3. The Retinal Determination Network: Membership Has Its Privileges;18
7.4;4. The Molecular Biology and Biochemistry of Retinal Determination;20
7.5;5. One Network yet Several Incarnations;26
7.6;6. Taking Instructions from Higher Authorities;32
7.7;7. Concluding Remarks;34
7.8;Acknowledgments;34
7.9;References;34
8;Chapter 2: Eye Field Specification in Xenopus laevis;42
8.1;1. Introduction;43
8.2;2. Tools for Studying Xenopus (and Eye) Development;44
8.3;3. Xenopus Eye Formation;46
8.4;4. Transcription Factors Regulating Eye Field and Early Eye Formation;49
8.5;5. Mechanisms Regulating Eye Field Specification and Early Eye Formation;61
8.6;6. Conclusions;65
8.7;Acknowledgments;66
8.8;References;66
9;Chapter 3: Eye Morphogenesis and Patterning of the Optic Vesicle;74
9.1;1. Introduction;75
9.2;2. Evagination of the Optic Vesicles;76
9.3;3. Patterning of the Optic Vesicle into RPE and Neural Retina;78
9.4;4. Optic Cup and Lens Morphogenesis;83
9.5;5. RPE Maintenance in the Optic Cup;87
9.6;6. Concluding Remarks;90
9.7;Acknowledgments;90
9.8;References;91
10;Chapter 4: Two Themes on the Assembly of the Drosophila Eye;98
10.1;1. Introduction;99
10.2;2. Interplay Between Cell Signaling and Competence Generates Diversity of Cell Types;101
10.3;3. Selective Adhesion Determines Spatial Patterns of Cells;119
10.4;4. Conclusions and Perspectives;129
10.5;Acknowledgments;130
10.6;References;130
11;Chapter 5: Building a Fly Eye: Terminal Differentiation Events of the Retina, Corneal Lens, and Pigmented Epithelia;142
11.1;1. Overview;143
11.2;2. The Retina: Drosophila PR Differentiation;146
11.3;3. The Corneal Lens;162
11.4;4. SPCs and TPCs: The Fly Retinal Pigment Epithelia?;169
11.5;5. Comparison of the Drosophila Eye with the Vertebrate Eye;171
11.6;6. Summary;175
11.7;Acknowledgments;175
11.8;References;176
12;Chapter 6: Retinal Progenitor Cells, Differentiation, and Barriers to Cell Cycle Reentry;188
12.1;1. Introduction;189
12.2;2. Retinal Progenitor Cells;190
12.3;3. Retinal Progenitor Cell Heterogeneity;191
12.4;4. Proliferation and Differentiation in Neurons;192
12.5;5. Conclusions;198
12.6;References;199
13;Chapter 7: Planar Cell Polarity Signaling in the Drosophila Eye;202
13.1;1. Introduction;203
13.2;2. PCP in the Drosophila Eye;204
13.3;3. The Core PCP Pathway and Its Effectors;209
13.4;4. Upstream PCP Components;225
13.5;5. Additional Components Affecting PCP Signaling in the Eye;230
13.6;6. Conclusions;231
13.7;Acknowledgments;232
13.8;References;232
14;Chapter 8: Milestones and Mechanisms for Generating Specific Synaptic Connections between the Eyes and the Brain;242
14.1;1. Introduction;243
14.2;2. Connecting the Eyes to the Brain;243
14.3;3. Conclusions and Future Directions;264
14.4;Acknowledgments;265
14.5;References;265
15;Index;274
16;Contents of Previous Volumes;280
17;Colour Plate;314