Jeon International Review of Cell and Molecular Biology

1. Auflage 2011
ISBN: 978-0-12-386042-2
Verlag: Elsevier Science & Techn.
Format: EPUB
Kopierschutz: 6 - ePub Watermark

E-Book, Englisch, Band Volume 288, 280 Seiten

Reihe: International Review of Cell and Molecular Biology

International Review of Cellÿand Molecular Biology presents current advances and comprehensive reviews in cell biology--both plant and animal. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. Impact factor for 2009: 6.088. - Authored by some of the foremost scientists in the field - Provides up-to-date information and directions for future research - Valuable reference material for advanced undergraduates, graduate students and professional scientists

Autoren/Hrsg.

Jeon, Kwang W.

Inhaltsverzeichnis

1;Front Cover;1
2;International Review of Cell and Molecular Biology;4
3;Copyright;5
4;Contents;6
5;Contributors;10
6;Chapter 1: The Membrane Receptor for Plasma Retinol-Binding Protein, A New Type of Cell-Surface Receptor;12
6.1;1. Introduction;14
6.2;2. Diverse Physiological Functions of Vitamin A, a Molecule Essential for Vertebrate Survival;15
6.3;3. Retinol-Binding Protein, the Specific Carrier of Vitamin A in Blood;18
6.4;4. Diverse Evidence for the Existence of an RBP Receptor that Mediates Vitamin A Uptake;20
6.5;5. Identification of RBP Receptor;23
6.6;6. Structure and Function Analysis of the RBP Receptor's Interaction with RBP;31
6.7;7. Pertinent Questions Related to RBP Receptor;34
6.8;8. RBP Receptor as a Potential Target in Treating Human Diseases;40
6.9;9. Concluding Remarks;43
6.10;Acknowledgments;43
6.11;References;43
7;Chapter 2: Vascular Smooth-Muscle-Cell Activation...;54
7.1;1. Introduction;55
7.2;2. Characteristics of Vascular Smooth-Muscle Cells;56
7.3;3. Proteomics Approaches for VSMC Proteome Mapping;69
7.4;4. Posttranslational Modifications and Their Biological Functions in VSMCs;80
7.5;5. From Putative Markers to New Therapeutic Targets;89
7.6;6. Concluding Remarks;97
7.7;Acknowledgments;98
7.8;References;98
8;Chapter 3: Molecular Basis for Endothelial Lumen Formation and Tubulogenesis During Vasculogenesis and Angiogenic Sprouting;112
8.1;1. Introduction;114
8.2;2. Overview of Endothelial Lumen Formation and Tubulogenesis;117
8.3;3. Molecular Mechanisms Controlling Vascular Lumen Formation;130
8.4;4. Functional Roles of Cdc42 and Rac1 in EC Lumen and Tube Formation;139
8.5;5. Roles of MT1-MMP and Vascular Guidance Tunnels in EC Lumen Formation and Tube Remodeling Events;147
8.6;6. Mechanisms Controlling EC Lumen and Tube Stability;155
8.7;7. Role for MMPs in the Molecular Control of Vascular Tube Regression Responses;162
8.8;8. Conclusions and Future Directions;164
8.9;Acknowledgments;165
8.10;References;165
9;Chapter 4: SUMO and Its Role in Human Diseases;178
9.1;1. Introduction;179
9.2;2. The Sumoylation Cycle;179
9.3;3. Sumoylation and Cancer;181
9.4;4. Sumoylation of Proteins Involved in Neurodegenerative Diseases;182
9.5;5. Sumoylation and Heart Disease;188
9.6;6. Concluding Remarks;189
9.7;Acknowledgments;190
9.8;References;190
10;Chapter 5: Focal Adhesion Kinase...;196
10.1;1. Introduction;197
10.2;2. Biological and Physiological Significance of FAK;198
10.3;3. Domain Structure;202
10.4;4. Autoinhibition;210
10.5;5. FAK Binding Partners;215
10.6;6. Development of FAK Therapeutics;223
10.7;7. Future Directions;226
10.8;References;227
11;Chapter 6: Roles of Small Ubiquitin-Related Modifiers in Male Reproductive Function;238
11.1;1. Introduction;239
11.2;2. Regulation of Protein Functions by Sumoylation: Lessons from Other Cell Types;241
11.3;3. Unique Aspects of Sumoylation in Male Germ Cells;247
11.4;4. Concluding Remarks and Future Perspectives;262
11.5;Acknowledgments;263
11.6;References;263
12;Index;272