The Textbook of Nanoneuroscience and Nanoneurosurgery

1. Auflage 2013
ISBN: 978-1-4398-4941-5
Verlag: Taylor & Francis Inc

Buch, Englisch, 604 Seiten, Format (B × H): 179 mm x 262 mm, Gewicht: 1410 g

Nanoneuroscience, nanoneurosurgery, and nanobioelectronics have the potential to revolutionize medicine and improve the prevention, diagnosis, and treatment of neurological disorders over the next 10-20 years. The Textbook of Nanoneuroscience and Nanoneurosurgery presents a state-of-the-art review of the field, providing current information about nanoplatforms and their use in neurosurgery, neurology, neuroscience, and neuroradiology.

The text also reviews the latest regulatory guidelines that influence the translation of nanotechnological research from the laboratory to the clinic, as well as the most recent information on biodevices and pharmaceutical spinoffs. It highlights presidential and congressional initiatives and programs that may significantly impact the field in the near future. Chapters discuss the latest science and technologies—which are applied to diagnosis and treatment of neurological disorders—as well as regulatory issues that impact product development.

This volume describes advances that have already been translated to the clinic or hold significant promise for future application in nanoneurosurgery, as well as their potential impact. A full-color text, the book contains contributions by more than 120 researchers, original and descriptive illustrations, and more than 3,000 references. Offering broad coverage of nanotechnological applications in diverse areas and addressing FDA regulation and healthcare policy, this volume provides a foundation of ideas and methods for scientists and physicians to devise successful, less invasive procedures for future treatment of nervous system disorders.

Zielgruppe

Neurosurgeons, radiologists, neurologists, neuroscientists, engineers, graduate and medical students, medical residents, fellows and postdocs, technology/equipment manufacturers, (Medtronic, Styker, Cyberonics, Codman), government agencies (DOD,NIH, NASA), and foundations (Cure For Life Foundation, etc.).

Autoren/Hrsg.

Kateb, Babak

Heiss, John D.

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Chirurgie Neurochirurgie

Inhaltsverzeichnis

From Nanotechnology to Nanoneuroscience/Nanoneurosurgery and Nanobioelectronics: A Historical Review of Milestones. Nanoneurology and Nanoneurosurgery. Nanopolymers and Nanoconjugates for Central Nervous System Diagnostics and Therapies. Micelles and Liposomes: Lipid Nanovehicles for Intracerebral Drug Delivery. Peptide and Protein-Based Nanoparticles. Endohedral Metallofullerenes, Iron Oxide Agents, and Gold Nanoparticles for Brain Imaging. Carbon Nanoplatforms and Their Application for Neurological Disorders. Dendrimers. Ligand-Based Targeting of Therapeutic and Imaging Agents for Cancer. Immune-Based Targeting in Cancer. Directed Drug Convection Using Magnetic Nanoparticles as Therapeutic Carriers: Meeting the Challenge of Specific Brain Pharmacotherapeutics, Non-Ligand-Based Central Nervous System Targeting, Including Magnetic Focusing. Intralesional and Intraparenchymal Convection-Enhanced Delivery of Nanoparticles. Transport of Nanoparticles across Blood–Brain Barrier. Nanomedicine Treatment Strategies That Exploit Unique Characteristics of Tumor Vasculature and Microenvironment. Focused Ultrasound for Noninvasive Neuromodulation. Nanosensors. Implantable Infusion Pumps Incorporating Nanotechnology. Nanostructured Surfaces for Intracerebral Neurotransmitter Recording. Therapy for Neuronopathic Lysosomal Storage Diseases. Nanotechnology for Cerebral Aneurysm Treatment. Improving Treatment of Stroke through Nanotechnology. Molecular Medical Devices for Nanoneurosurgery. Applications of Nanotechnology in Epilepsy. Applications of Nanotechnology to Diseases of the Spine. Nanoparticle-Based Treatment and Imaging of Brain Tumors: Potentials and Limitations. Tumor-Targeted Nanodrugs for Treatment of Primary Brain Tumors. Application of Nanotechnology in the Diagnosis and Treatment of Brain Metastasis. Nanotechnology in Extra-Axial and Pituitary Tumors. Using Nanoparticles in Diagnosis and Treatment of CNS Infection. Applications of Nanotechnology in Movement Disorders. Nanomedicine in Demyelinating Disease: Application to Diagnosis and Therapy in Multiple Sclerosis. Applications of Nanotechnology in Degenerative Disorders of the Brain. Brain–Machine Interface and Rehabilitation. Nanobioelectronics for Noninvasive Neuronal Therapy. In Vitro and In Vivo Techniques to Assess Neurotoxicity of Nanoparticles. Nanorobotics for Neurosurgery. Imaging and Tracking Therapeutic Cells with Nanoparticles. Micro- and Nanotechnology in Nerve Repair. Nanotechnology: Applications to Pediatric Neurosurgery. Food and Drug Administration Regulatory Framework for Nanodrugs and Nanodevices and the Combination Nanodrug. Nanoneuroscience and Nanoneurosurgery: A Key Component of President Obama’s Brain Mapping Initiative.

Über Autor(innen)

Babak Kateb, founding chairman of the board of SBMT and Brain Mapping Foundation, Scientific Director of SBMT, and President of Brain Mapping Foundation, West Hollywood, CA, USA, Director of the National Center for Nano-Bio-Electronics, NASA Research Park, Moffet, CA, USA, Senior Editor of SBMT-NeuroMapping & Therapeutics, Research Scientist, Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA, and Visiting Scientist, NASA/Jet Propulsion Laboratory (JPL), Pasadena, CA, USA.

John D. Heiss, chair of the Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, and Clinical Professor of Neurosurgery, George Washington University, Washington, DC, USA.