Kaufmann Novel Vaccination Strategies

1. Auflage 2006
ISBN: 978-3-527-60609-2
Verlag: Wiley-VCH
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 628 Seiten, E-Book

Mit diesem Band verschaffen Sie sich einen Überblick über den gegenwärtigen Stand der Forschung auf dem Gebiet der Impfstoffe. Ausgehend von neuen Erkenntnissen in Molekularbiologie und Immunologie erläutern rund 30 Artikel Ansätze, die sich momentan im Übergang von der Grundlagenforschung zur Anwendung in der Humanmedizin befinden, sowie zukünftige Strategien. Auch hochaktuelle Themen, unter anderem die Abwehr biologischer Kampfstoffe, werden diskutiert.

Autoren/Hrsg.

Kaufmann, Stefan H. E.

Inhaltsverzeichnis

PART I
Preface
Introduction: Challenges for the vaccine developer, including correlates of protection

PART II
VACCINATION AND IMMUNE RESPONSE
Shaping adaptive immunity against pathogens: the contribution of innate immune responses
Adjuvant induced Th2 and Th1 dominated immune responses in vaccination
Memory
T-cell based vaccines

PART III
ADJUVANTS
Microbial adjuvants
Host derived adjuvants
Microparticles as vaccine adjuvants and delivery systems
Liposomes and ISCOMs
Virosomal technology and mucosal adjuvants

PART IV
CLASSICAL AND NOVEL VACCINATION STRATEGIES: A COMPARISON
Classical bacterial vaccines
Subunit vaccines and toxoids
Engineering virus vectors for subunit vaccines
Update on antiviral DNA vaccine research (2000-2003)
Live recombinant bacterial vaccines
Mucosal vaccination
Passive vaccination and antidotes: A novel strategy for generation of wide-spectrum protective antibodies
Plant-based oral vaccines
Virus-like particles: Combining innate and adaptive immunity for effective vaccination

PART V
VACCINES FOR SPECIFIC TARGETS
Helicobacter pylori
Tuberculosis: Novel vaccination strategies against tuberculosis
Rationale for malaria vaccine development
HIV
Vaccines against bioterror agents

Part VI
VACCINES IN THE REAL WORLD: SAFETY, COST-EFFICIENCY AND IMPACT OF VACCINATION
Imperfect vaccines and the evolution of pathogen virulence
Cost-effectiveness of vaccinations
Immunological safety of vaccines: facts, hypothesis and allegations

Index

Über Autor(innen)

Prof. Dr. Stefan H.E. Kaufmann, Scientific member of the Max Planck Society, Founding Director of the Max Planck Institute for Infection Biology, Berlin. More than 500 publications and reviews on immunology and infection. Member of numerous scientific societies and committees and winner of prestigious awards. One of the 100 most cited immunologists in the period of 1981 to 1999.