Klein Advances in Cancer Research

1. Auflage 2000
ISBN: 978-0-08-049022-9
Verlag: Elsevier Science & Techn.
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, Band Volume 79, 285 Seiten, Web PDF

Reihe: Advances in Cancer Research

Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here once again, outstanding and original reviews are presented. - New Paradigms for the Treatment of Cancer: The Role of Anti-aiogenesis Agents - The Hepatocyte Growth Factor/Met Pathway in Development, Tumorigenesis, and B-Cell Differentiation - Clinical Targets for Anti-metastasis Therapy - Animal Models of Melanoma: Recent Advances and Future Prospects - The Indispensable Role of Microenvironment in the Natural History of Low-Grade B-Cell Neoplasms - Epstein-Barr Virus Latency: LMP2, a Regulator or Means for Epstein-Barr Birus - Biochemistry and Pathological Importance of Mucin-Associated Antigens in Gastrointenstinal Neoplasia - Studies on Polyomavirus Persistence and Polyomavirus-Induced Tumor Development in Relation to the Immune System

Autoren/Hrsg.

Klein, George

Inhaltsverzeichnis

1;Cover;1
2;Contents;6
3;Contributors to Volume 79;10
4;Chapter 1. New Paradigms for the Treatment of Cancer: The Role of Anti-Angiogenesis Agents;12
4.1;I. Introduction;13
4.2;II. Growth Factors and Receptor Tyrosine Kinases;15
4.3;III. Platelet-Derived Endothelial Cell Growth Factor/Thymidine Phosphorylase;27
4.4;IV. Matrix Metalloproteinases;29
4.5;V. Plasminogen Activator/Plasmin System;35
4.6;VI. Integrins;37
4.7;VII. Other;39
4.8;VIII. Conclusions;40
4.9;References;41
5;Chapter 2. The Hepatocyte Growth Factor/Met Pathway in Development, Tumorigenesis, and B-Cell Differentiation;50
5.1;I. Introduction;50
5.2;II. Structure and Function of HGF and Met;51
5.3;III. HGF/Met in B-Cell Development and Neoplasia;79
5.4;IV. Summary;86
5.5;References;86
6;Chapter 3. Clinical Targets for Anti-Metastasis Therapy;102
6.1;I. Introduction;103
6.2;II. Metastasis: Clinical and Experimental Considerations;104
6.3;III. New Tools for Studying the Metastatic Process;106
6.4;IV. New Insights into the Metastatic Process;111
6.5;V. Targets for Anti-Metastasis Therapy: Clinical and Biological Considerations;121
6.6;VI. Conclusions;129
6.7;References;129
7;Chapter 4. Animal Models of Melanoma: Recent Advances and Future Prospects;134
7.1;I. Introduction;134
7.2;II. Clinical Aspects of Melanoma;135
7.3;III. Molecular Basis for Melanoma;138
7.4;IV. Role of Receptor Tyrosine Kinases;146
7.5;V. Model Systems for Melanoma;150
7.6;VI. Conclusions;160
7.7;References;161
8;Chapter 5. The Indispensable Role of Microenvironment in the Natural History of Low-Grade B-Cell Neoplasms;168
8.1;I. Introduction;169
8.2;II. More Characters Are Coming on the Stage;169
8.3;III. Conclusions;181
8.4;References;181
9;Chapter 6. Epstein–Barr Virus Latency: LMP2, A Regulator or Means for Epstein–Barr Virus Persistence?;186
9.1;I. Introduction;187
9.2;II. EBV Latency;188
9.3;III. Latent Membrane Protein 2;189
9.4;IV. B-Cell Signal Transduction and LMP2A;194
9.5;V. LMP2A Site-Specific Mutant LCLs;196
9.6;VI. Model of LMP2A and LMP2B Function in Vitro;200
9.7;VII. In Vivo Models of LMP2A Function;202
9.8;VIII. LMP2 Function in Epithelial Cells;203
9.9;IX. Discussion;204
9.10;References;208
10;Chapter 7. Biochemistry and Pathological Importance of Mucin-Associated Antigens in Gastrointestinal Neoplasia;212
10.1;I. Introduction;212
10.2;II. Biochemistry and Molecular Biology of Mucins;213
10.3;III. Alterations of Mucin Peptide and Mucin Glycosylation during Carcinogenesis;227
10.4;IV. Expression of Mucin-Associated Antigens in Gastric Tissues;230
10.5;V. Expression in Colorectal Tissues;235
10.6;VI. Prognostic Relevance in Gastrointestinal Cancer;242
10.7;VII. Serum Tumor Markers (Circulating Antigens);244
10.8;VIII. Functional Aspects Regarding Invasion and Metastasis;245
10.9;IX. Perspectives in Tumor Immunology and Cancer Therapy;247
10.10;References;249
11;Chapter 8. Studies on Polyomavirus Persistence and Polyomavirus-Induced Tumor Development in Relation to the Immune System;260
11.1;I. Introduction;260
11.2;II. Initial Studies on Polyomavirus Infection and Polyoma-Specific Immune Reponses in Vivo and in Vitro ;261
11.3;III. Molecular Characteristics of Polyomavirus;263
11.4;IV. Polyomavirus Tumor-Specific Transplantation Antigens;264
11.5;V. Factors Influencing Polyomavirus Persistence and Polyomavirus-Induced Tumor Development ;265
11.6;VI. Studies on Polyomavirus Persistence and Polyomavirus-Induced Tumor Development in Immunocompetent and Immunodeficient Mice ;267
11.7;VII. Concluding Remarks;282
11.8;VIII. Future Prospects;284
11.9;References;284
12;Index;288