Klein Advances in Cancer Research

1. Auflage 1995
ISBN: 978-0-08-056249-0
Verlag: Elsevier Science & Techn.
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, Band Volume 67, 328 Seiten, Web PDF

Reihe: Advances in Cancer Research

Advances in Cancer Research is a biannual publication that includes timely reviews on the most cutting-edge issues in cancer research. Topics covered in Volume 67 include a developmental model of progenitor cell oncogenesis based on a description of transcriptional control; pathways of chromosome alteration in human epithelial cancers, using colorectal, breast, lung, and endometrial cancers as examples; the genetics of murine lung tumors; the molecular pathogenesis of AIDS-related lymphomas; HLA class I antigens in human tumors, focusing on abnormal MHC expression detected in human tumors and the biological role these alterations may have in tumor development; a summary of the information obtained by the molecular characterization of EBV diversity and discussion of its relevance for viral epidemiology, transmission, and pathogenesis. There are two reviews discussing angiogenesis: the first focuses on the role of scatter factor and the second, the VEGF-FH receptor system. The 'Foundations in Cancer Research' article by Alfred G. Knudson is a personal account of his career studying mutation and cancer. - A 'Foundations in Cancer Research' article by Alfred G. Knudson, a personal account of his career studying mutation and cancer - A developmental model of progenitor cell oncogenesis based on a disruption of transcriptional control - Pathways of chromosome alteration in human epithelial cancers, using colorectal, breast, lung, and endometrial cancers as examples - A review of the genetics of murine lung tumors - Molecular pathogenesis of AIDS-related lymphomas - HLA class I antigens in human tumors, focusing on abnormal MHC expression detected in human tumors and the biological role these alterations may have in tumor development - A summary of the information obtained by the molecular characterization of EBV diversity and discussion of its relevance for viral epidemiology, transmission, and pathogenesis - The role of scatter factor in angiogenesis - The role of the VEGF-FH receptor system in normal and tumor angiogenesis

Autoren/Hrsg.

Klein, George

Inhaltsverzeichnis

1;Cover;1
2;Contents;6
3;Contributers to Volume 67;10
4;Chapter 1. Foundation in Cancer Research Mutation and Cancer: A Personal Odyssey;12
4.1;I. Viruses, Somatic Mutations, and Cancer ;12
4.2;II. Human Cancer Genes;18
4.3;III. The Emergence of Antioncogenes;23
4.4;IV. Conclusions;29
4.5;References;30
5;Chapter 2. Oncogenic Role of MasterŽ Transcription Factors in Human Leukemias and Sarcomas: A Developmental Model;36
5.1;I. Introduction;36
5.2;II. Transcriptional Control Genes Altered by Chromosomal Rearrangements ;37
5.3;III. Oncogenic Transription Factors and the Developmental Regulatory Proteins of Drosophila;54
5.4;IV. Summary and Future Directions;61
5.5;References;63
6;Chapter 3. Pathways of Chromosome Alteration in Human Epithelial Cancers;70
6.1;I. Introduction;70
6.2;II. Colorectal Adenocarcinoma;72
6.3;III. Other Epithelial Tumors;79
6.4;IV. Microsatellite Instability in Epithelial Tumors;85
6.5;V. Concluding;88
6.6;References;89
7;Chapter 4. Genetics of Murine Lung Tumors;94
7.1;I. Historical Aspects;94
7.2;II. Comparative Aspects;95
7.3;III. Genetic Linkage Studies;106
7.4;IV. Transgenic Models of Lung Tumorigenesis;110
7.5;V. Candidate Lung Tumor Susceptibility Genes;111
7.6;VI. Genetics of Lung Tumors, Human;113
7.7;VII. Conclusions and Perspectives;116
7.8;References;117
8;Chapter 5. Molecular Pathogenesis of AIDS-Related Lymphomas;124
8.1;I. Epidemiology of AlDS-Related Lymphomas ;124
8.2;II. Clinicopathologic Spectrum of AIDS-Related Lymphomas;126
8.3;III. Natural History of AIDS-Related Lymphomas;129
8.4;IV. Host Factors Contributing to AIDS-Related Lymphoma Development;131
8.5;V. Role of Viral Infection in AlDS-Related Lymphomagenesis;137
8.6;VII. Genetic Lesions Involved in AIDS-Related Lymphomas;143
8.7;VII. Conclusions: Distinct Pathogenetic Pathways in the Development of AIDS-Related Lymphomas;150
8.8;References;154
9;Chapter 6. HLA Class I Antigens in Human Tumors;166
9.1;I. Introduction;166
9.2;II. HLA Class I Antigen Expression in Normal Tissues;168
9.3;III. Role of MHC in T and NK Cell Recognition;177
9.4;IV. HLA and Tumor Antigens;181
9.5;V. Alterations of HLA Class I Expression in Human Tumors;182
9.6;VI. Clinical Implications;195
9.7;VII. Conclusions;195
9.8;References;196
10;Chapter 7. Molecular Epidemiology of Epstein–Barr Virus Infection;208
10.1;I. Introduction;208
10.2;II. EBV Genome and Gene Expression;211
10.3;III. EBV Typing at the DNA Level (Genotyping);215
10.4;IV. EBV Typing at the Protein Level (Ebnotyping);237
10.5;V. Differential Recognition of EBV Genotypes by the Immune System;248
10.6;VI. Final Conclusions: Implications for the Biology of EBV Infection;252
10.7;References;257
11;Chapter 8. Scatter Factor and Angiogenesis;268
11.1;I. Introduction: Scatter Factor (Hepatocyte Growth Factor) and the c-met Receptor;268
11.2;II. SF Biologic Actions on Blood Vessel Wall Cells in Vitro and in Vivo;270
11.3;III. SF as a Potential Tumor Angiogenesis Factor;277
11.4;IV. Role of SF in Angiogenesis: Hypotheses and Future Directions;284
11.5;V. Summary and Conclusions;288
11.6;References;289
12;Chapter 9. Role of VEGF-Flt Receptor System in Normal and Tumor Angiogenesis;294
12.1;I. Introduction;294
12.2;II. Structure and Functions of VEGF/VPF;296
12.3;III. Fit Receptor Gene Family: The Major Receptors for VEGF;309
12.4;IV. Regulation of Tumor Growth by the Suppression of VEGF-Flt Receptor System;322
12.5;References;324
13;Index;330