Konopka / Crabbe Compact Handbook of Computational Biology

Erscheinungsjahr 2004
ISBN: 978-0-203-02141-5
Verlag: Taylor & Francis
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 572 Seiten

The assimilation of computational methods into the life sciences has played an important role in advancing biological research. From sequencing genomes to discovering motifs in large collections of functionally equivalent sequences of nucleic acids and proteins, the value of powerful computational tools has become abundantly clear. The Compact Handbook of Computational Biology describes the foundational concepts, techniques, and challenges of biomolecular sequence analysis, biopolymer structure analysis and prediction, genomics, and molecular evolution.

Comprising contributions from renowned scientists, many of whom pioneered current methodologies, the Compact Handbook of Computational Biology offers interdisciplinary and authoritative coverage of methods for analysis of nucleic acid and protein sequences and structures, definition and detection of motifs in nucleic acid and protein sequences, protein structure prediction, and discrete modeling of biopolymers. Specific computational topics include computer-assisted research on protein folding, computer-assisted studies of DNA-protein interactions, computer-assisted genomics, proteomics, and comparative genomics, and computer-assisted studies of genome evolution at the molecular (DNA) level.

Offering a survey of specific algorithms that have proven successful in molecular biology, genomics, structural biology, and bioinformatics, this invaluable handbook is an authoritative source covering terminology, software, and applications of computational biology.

Zielgruppe

Computational biologists, computer scientists, software engineers, molecular biologists, biochemists, biotechnologists, bioengineers, systems scientists, forensic scientists, biomedical professionals, journalists, historians of science, philosophers, and undergraduate and graduate students of bioinformatics and related disciplines.

Autoren/Hrsg.

Konopka, A.K.

Crabbe, M. James C.

Fachgebiete

• Naturwissenschaften Biowissenschaften Biowissenschaften
• Mathematik | Informatik Mathematik Numerik und Wissenschaftliches Rechnen Computeranwendungen in der Mathematik
• Mathematik | Informatik Mathematik Numerik und Wissenschaftliches Rechnen Angewandte Mathematik, Mathematische Modelle

Inhaltsverzeichnis

Foreword
Contributors
Introduction: Computational Biology in 14 Brief Paragraphs
A.K. Konopka and M.J.C. Crabbe

BIOMOLECULAR SEQUENCE ANALYSIS
Introduction to Pragmatic Analysis of Nucleic Acid Sequences
A.K. Konopka
Motifs in Sequences: Localization and Extraction
M. Crochemore and M-F. Sagot
Protein Sequence Analysis and Prediction of Secondary Structural Features
J. Heringa

BIOPOLYMER STRUCTURE CALCULATION AND PREDICTION
Discrete Models of Biopolymers
P. Schuster and P.F. Stadler
Protein Structure Folding and Prediction
W.R. Taylor
DNA-Protein Interactions: Target Prediction
A. Sarai and H. Kono

GENOME ANALYSIS AND EVOLUTION
Methods of Computational Genomics: An Overview
F. Lisacek
Computational Aspects of Comparative Genomics
W. Makalowski and I. Makalowska
Computational Methods for Studying the Evolution of the Mitochondrial Genome
C. Saccone and G. Pesole

Appendix 1: Computational Biology: Annotated Glossary of Terms
A.K. Konopka, P. Bucher, M.J.C. Crabbe, M. Crochemore, J. Heringa, F. Lisacek, I. Makalowska, G. Pesole, C. Saccone, M-F. Sagot, A. Sarai, P. Stadler, and W.R. Taylor
Appendix 2: A Dictionary of Programs for Sequence Analysis
A.K. Konopka and J. Heringa
Index